Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O07399 (FABG_MYCAV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
OrganismMycobacterium avium
Taxonomic identifier1764 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2552553-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054675

Regions

Nucleotide binding30 – 334NADP By similarity
Nucleotide binding69 – 702NADP By similarity
Nucleotide binding161 – 1655NADP By similarity

Sites

Active site1611Proton acceptor By similarity
Binding site551NADP By similarity
Binding site961NADP; via carbonyl oxygen By similarity
Binding site1481Substrate By similarity
Binding site1941NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
O07399 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: C3A20AA0B6251655

FASTA25526,706
        10         20         30         40         50         60 
MTDTATENTT ESAADYGRPA FVSRSVLVTG GNRGIGLAIA QRLAAEAHKV AVTHRGSGAP 

        70         80         90        100        110        120 
DGLFGVECDV TDNDAVDRAF TEVEEHQGPV EVLVSNAGIS KDAFLIRMTE ERFTEVINAN 

       130        140        150        160        170        180 
LTGAFRVTQR AARSMQKKRF GRIIYIGSVS GMWGIGNQAN YAAAKAGLIG MARSISRELS 

       190        200        210        220        230        240 
KAGVTANVVA PGYIDTEMTR ALDERIQAGA LEFIPAKRVG TAAEVPGAVS FLASEDASYI 

       250 
AGAVIPVDGG MGMGH 

« Hide

References

[1]"Determination of a 15437 bp nucleotide sequence around the inhA gene of Mycobacterium avium and similarity analysis of the products of putative ORFs."
Labo M., Gusberti L., de Rossi E., Speziale P., Riccardi G.
Microbiology 144:807-814(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GIR10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF002133 Genomic DNA. Translation: AAC46203.1.

3D structure databases

ProteinModelPortalO07399.
SMRO07399. Positions 17-255.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1028.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_MYCAV
AccessionPrimary (citable) accession number: O07399
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways