Reviewed, UniProtKB/Swiss-Prot O07399 (FABG_MYCAV)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase
    EC=1.1.1.100
Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase

Gene names

Name:

fabG

Organism

Mycobacterium avium

Taxonomic identifier

1764 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase activity Inferred from electronic annotation. Source: EC NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	3-oxoacyl-[acyl-carrier-protein] reductase		PRO_0000054675
Regions
	Nucleotide binding	13 – 39	27	NADP By similarity
Sites
	Active site	161	1	Proton acceptor By similarity
	Binding site	148	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O07399-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: C3A20AA0B6251655	FASTA	255	26,706
	10 20 30 40 50 60 MTDTATENTT ESAADYGRPA FVSRSVLVTG GNRGIGLAIA QRLAAEAHKV AVTHRGSGAP 70 80 90 100 110 120 DGLFGVECDV TDNDAVDRAF TEVEEHQGPV EVLVSNAGIS KDAFLIRMTE ERFTEVINAN 130 140 150 160 170 180 LTGAFRVTQR AARSMQKKRF GRIIYIGSVS GMWGIGNQAN YAAAKAGLIG MARSISRELS 190 200 210 220 230 240 KAGVTANVVA PGYIDTEMTR ALDERIQAGA LEFIPAKRVG TAAEVPGAVS FLASEDASYI 250 AGAVIPVDGG MGMGH

References

[1]

"Determination of a 15437 bp nucleotide sequence around the inhA gene of Mycobacterium avium and similarity analysis of the products of putative ORFs." Labo M., Gusberti L., de Rossi E., Speziale P., Riccardi G. Microbiology 144:807-814(1998) [PubMed: 9534249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GIR10.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF002133 Genomic DNA. Translation: AAC46203.1.
3D structure databases
HSSP	HSSP built from PDB template 1E7W based on UniProtKB Q01782.
SMR	O07399. Positions 17-255.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.100. 599.
Family and domain databases
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_MYCAV

Accession

Primary (citable) accession number: O07399

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)