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Protein

Phytoene synthase

Gene

crtB

Organism
Arthrospira platensis (Spirulina platensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reaction from prephytoene diphosphate to phytoene.

Catalytic activityi

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi: phytoene biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Phytoene synthase (crtB)
This subpathway is part of the pathway phytoene biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate, the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCarotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.

Names & Taxonomyi

Protein namesi
Recommended name:
Phytoene synthase (EC:2.5.1.32)
Gene namesi
Name:crtB
Synonyms:pys
OrganismiArthrospira platensis (Spirulina platensis)
Taxonomic identifieri118562 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesMicrocoleaceaeArthrospira

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674361 – 309Phytoene synthaseAdd BLAST309

Proteomic databases

PRIDEiO07333.

Structurei

3D structure databases

ProteinModelPortaliO07333.
SMRiO07333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105FE1. Bacteria.
COG1562. LUCA.

Family and domain databases

CDDicd00683. Trans_IPPS_HH. 1 hit.
Gene3Di1.10.600.10. 1 hit.
InterProiView protein in InterPro
IPR008949. Isoprenoid_synthase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR033904. Trans_IPPS_HH.
PfamiView protein in Pfam
PF00494. SQS_PSY. 1 hit.
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiView protein in PROSITE
PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O07333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQLSKSPCM RTPATRSDSY ELCRQITAQY AKTFYLGTQL MPLAKRQAIW
60 70 80 90 100
AIYVWCRRTD ELVDGPMASS TTLETLDHWE EQLESIFAGH PIEPVDVALV
110 120 130 140 150
DTLGRFPLDI QPFRDMIAGQ RMDLSRNRYN TFDELNLYCY RVAGTVGLMS
160 170 180 190 200
LAVMGTAEPD LSVPWNRDQS IYYPKEEAIA LGIANQLTNI LRDVGEDARR
210 220 230 240 250
GRIYLPLDDL ALFNYTEADL LNGKVDERWR ELMRFQIQRA RKFYTLAEEG
260 270 280 290 300
IAALHPDIRW PVWTALMLYR QILDEIERNE YDVFNQRAYV PTWKKMMCLP

LAQLRARVL
Length:309
Mass (Da):35,945
Last modified:July 1, 1997 - v1
Checksum:iC42A1C6431604C75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001284 Genomic DNA. Translation: BAA20384.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCRTY_ARTPT
AccessioniPrimary (citable) accession number: O07333
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: July 5, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families