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O07293 (BLO18_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase OXA-18

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:bla
Synonyms:oxa18
OrganismPseudomonas aeruginosa
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has a broad substrate profile, hydrolyzes amoxicillin, ticarcillin, cephalothin, ceftazidime, cefotaxime, and aztreonam, but not imipenem or cephamycins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulation

Inhibited by clavulanic acid.

Sequence similarities

Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

penicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 275242Beta-lactamase OXA-18
PRO_0000017033

Regions

Region210 – 2123Substrate binding By similarity

Sites

Active site651Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue681N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O07293 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 7D3B71C3ABCE411A

FASTA27530,602
        10         20         30         40         50         60 
MQRSLSMSGK RHFIFAVSFV ISTVCLTFSP ANAAQKLSCT LVIDEASGDL LHREGSCDKA 

        70         80         90        100        110        120 
FAPMSTFKLP LAIMGYDADI LLDATTPRWD YKPEFNGYKS QQKPTDPTIW LKDSIVWYSQ 

       130        140        150        160        170        180 
ELTRRLGESR FSDYVQRFDY GNKDVSGDPG KHNGLTHAWL ASSLKISPEE QVRFLRRFLR 

       190        200        210        220        230        240 
GELPVSEDAL EMTKAVVPHF EAGDWDVQGK TGTGSLSDAK GGKAPIGWFI GWATRDDRRV 

       250        260        270 
VFARLTVGAR KGEQPAGPAA RDEFLNTLPA LSENF 

« Hide

References

[1]"OXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa."
Philippon L.N., Naas T., Bouthors A.T., Barakett V., Nordmann P.
Antimicrob. Agents Chemother. 41:2188-2195(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Mus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U85514 Genomic DNA. Translation: AAB58555.1.

3D structure databases

ProteinModelPortalO07293.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLO18_PSEAI
AccessionPrimary (citable) accession number: O07293
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: July 1, 1997
Last modified: October 16, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families