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Protein
Submitted name:

Possible transcriptional regulatory protein (Possibly TetR/AcrR-family)

Gene

Rv0328

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 47H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Possible transcriptional regulatory protein (Possibly TetR/AcrR-family)Imported
Submitted name:
TetR family transcriptional regulatorImported
Gene namesi
Ordered Locus Names:Rv0328Imported
ORF Names:LH57_01785Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0328.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • plasma membrane Source: MTBBASE

PTM / Processingi

Proteomic databases

PRIDEiO07252.

Structurei

3D structure databases

ProteinModelPortaliO07252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 65HTH tetR-type DNA-bindingInterPro annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG4105HQE. Bacteria.
ENOG4111PFX. LUCA.
HOGENOMiHOG000220316.
OMAiCLYERGY.
PhylomeDBiO07252.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
PfamiView protein in Pfam
PF00440. TetR_N. 1 hit.
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiView protein in PROSITE
PS50977. HTH_TETR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O07252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQQRTNRDK LLDGALACLR ERGYGNTSSR DIARAAGVNI ASINYHFGSK
60 70 80 90 100
DALLDDALGR CFSTWNQRVQ EAFDHSRAAG PAGQILAVLE ATVDSFEQIR
110 120 130 140 150
PAVYACVESY APALRSEALR ERLAAGYADV RQHSVDLAGA ALAGTDIAPP
160 170 180 190 200
ENLSTIVSVL MAVIDGLMIQ WIADPSATPR STEVIRALAS IGAVVTSQLR
Length:200
Mass (Da):21,411
Last modified:July 1, 1997 - v1
Checksum:i81ADC84B554B5EC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13050.1.
AL123456 Genomic DNA. Translation: CCP43058.1.
RefSeqiNP_214842.1. NC_000962.3.
WP_003401651.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR13050; AIR13050; LH57_01785.
CCP43058; CCP43058; Rv0328.
GeneIDi886542.
KEGGimtu:Rv0328.
mtv:RVBD_0328.
PATRICi18122466. VBIMycTub22151_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13050.1.
AL123456 Genomic DNA. Translation: CCP43058.1.
RefSeqiNP_214842.1. NC_000962.3.
WP_003401651.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO07252.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO07252.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR13050; AIR13050; LH57_01785.
CCP43058; CCP43058; Rv0328.
GeneIDi886542.
KEGGimtu:Rv0328.
mtv:RVBD_0328.
PATRICi18122466. VBIMycTub22151_0367.

Organism-specific databases

TubercuListiRv0328.

Phylogenomic databases

eggNOGiENOG4105HQE. Bacteria.
ENOG4111PFX. LUCA.
HOGENOMiHOG000220316.
OMAiCLYERGY.
PhylomeDBiO07252.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
PfamiView protein in Pfam
PF00440. TetR_N. 1 hit.
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiView protein in PROSITE
PS50977. HTH_TETR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO07252_MYCTU
AccessioniPrimary (citable) accession number: O07252
Secondary accession number(s): F2GN18, I6XV08, Q7DA05
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: February 15, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.