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Protein
Submitted name:

Probable serine protease PepA (Serine proteinase) (MTB32A)

Gene

pepA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Probable serine protease PepA (Serine proteinase) (MTB32A)Imported
Submitted name:
Serine proteaseImported
Gene namesi
Name:pepAImported
Ordered Locus Names:Rv0125Imported
ORF Names:LH57_00705Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0125.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • extracellular region Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 355323Sequence analysisPRO_5007696670Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0125.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 31652PDZ (DHR)InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4108MF7. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223641.
OMAiLIQADAP.
OrthoDBiEOG6423DD.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSRRRSLR WSWLLSVLAA VGLGLATAPA QAAPPALSQD RFADFPALPL
60 70 80 90 100
DPSAMVAQVG PQVVNINTKL GYNNAVGAGT GIVIDPNGVV LTNNHVIAGA
110 120 130 140 150
TDINAFSVGS GQTYGVDVVG YDRTQDVAVL QLRGAGGLPS AAIGGGVAVG
160 170 180 190 200
EPVVAMGNSG GQGGTPRAVP GRVVALGQTV QASDSLTGAE ETLNGLIQFD
210 220 230 240 250
AAIQPGDSGG PVVNGLGQVV GMNTAASDNF QLSQGGQGFA IPIGQAMAIA
260 270 280 290 300
GQIRSGGGSP TVHIGPTAFL GLGVVDNNGN GARVQRVVGS APAASLGIST
310 320 330 340 350
GDVITAVDGA PINSATAMAD ALNGHHPGDV ISVTWQTKSG GTRTGNVTLA

EGPPA
Length:355
Mass (Da):34,926
Last modified:July 1, 1997 - v1
Checksum:i16CE9E21A97BF192
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12846.1.
AL123456 Genomic DNA. Translation: CCP42850.1.
RefSeqiNP_214639.1. NC_000962.3.
WP_003400885.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR12846; AIR12846; LH57_00705.
CCP42850; CCP42850; Rv0125.
GeneIDi886924.
KEGGimtu:Rv0125.
mtv:RVBD_0125.
PATRICi18122018. VBIMycTub22151_0144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12846.1.
AL123456 Genomic DNA. Translation: CCP42850.1.
RefSeqiNP_214639.1. NC_000962.3.
WP_003400885.1. NZ_KK339370.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR12846; AIR12846; LH57_00705.
CCP42850; CCP42850; Rv0125.
GeneIDi886924.
KEGGimtu:Rv0125.
mtv:RVBD_0125.
PATRICi18122018. VBIMycTub22151_0144.

Organism-specific databases

TubercuListiRv0125.

Phylogenomic databases

eggNOGiENOG4108MF7. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223641.
OMAiLIQADAP.
OrthoDBiEOG6423DD.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiO07175_MYCTU
AccessioniPrimary (citable) accession number: O07175
Secondary accession number(s): F2GLS2, I6XUH1, Q7DAF8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.