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Protein

Probable enoyl-CoA hydratase echA8

Gene

echA8

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Could possibly oxidize fatty acids using specific components.By similarity

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable enoyl-CoA hydratase echA8 (EC:4.2.1.17)
Gene namesi
Name:echA8
Ordered Locus Names:ML2402
ORF Names:MLCB1306.05c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2402.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Probable enoyl-CoA hydratase echA8PRO_0000109337Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2402.

Structurei

3D structure databases

ProteinModelPortaliO07137.
SMRiO07137. Positions 2-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E39. Bacteria.
COG1024. LUCA.
HOGENOMiHOG000027939.
KOiK01692.
OMAiVSKIYPV.
OrthoDBiPOG091H01K6.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDTILVDG YQRVGIITLN RPQALNALNS QMMNEITNAA KELDIDPDVG
60 70 80 90 100
AILITGSPKV FAAGADIKEM ASLTFTDAFD ADFFSAWGKL AAVRTPMIAA
110 120 130 140 150
VAGYALGGGC ELAMMCDLLI AADTAKFGQP EIKLGVLPGM GGSQRLTRAI
160 170 180 190 200
GKAKAMDLIL TGRTIDAAEA ERSGLVSRVV LADDLLPEAK AVATTISQMS
210 220 230 240 250
RSATRMAKEA VNRSFESTLA EGLLHERRLF HSTFVTDDQS EGMAAFIEKR

APQFTHR
Length:257
Mass (Da):27,517
Last modified:July 1, 1997 - v1
Checksum:i25B801EB690BCD00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13803 Genomic DNA. Translation: CAA74130.1.
AL583925 Genomic DNA. Translation: CAC31918.1.
PIRiF87209.
RefSeqiNP_302555.1. NC_002677.1.
WP_010908875.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31918; CAC31918; CAC31918.
GeneIDi908604.
KEGGimle:ML2402.
PATRICi18059413. VBIMycLep78757_4621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13803 Genomic DNA. Translation: CAA74130.1.
AL583925 Genomic DNA. Translation: CAC31918.1.
PIRiF87209.
RefSeqiNP_302555.1. NC_002677.1.
WP_010908875.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO07137.
SMRiO07137. Positions 2-256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31918; CAC31918; CAC31918.
GeneIDi908604.
KEGGimle:ML2402.
PATRICi18059413. VBIMycLep78757_4621.

Organism-specific databases

LepromaiML2402.

Phylogenomic databases

eggNOGiENOG4105E39. Bacteria.
COG1024. LUCA.
HOGENOMiHOG000027939.
KOiK01692.
OMAiVSKIYPV.
OrthoDBiPOG091H01K6.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECHA8_MYCLE
AccessioniPrimary (citable) accession number: O07137
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.