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Protein

Probable enoyl-CoA hydratase echA8

Gene

echA8

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could possibly oxidize fatty acids using specific components.By similarity

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-2633-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable enoyl-CoA hydratase echA8 (EC:4.2.1.17)
Gene namesi
Name:echA8
Ordered Locus Names:ML2402
ORF Names:MLCB1306.05c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2402

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001093371 – 257Probable enoyl-CoA hydratase echA8Add BLAST257

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2402

Structurei

3D structure databases

ProteinModelPortaliO07137
SMRiO07137
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E39 Bacteria
COG1024 LUCA
HOGENOMiHOG000027939
KOiK01692
OMAiCGIVARI
OrthoDBiPOG091H01K6

Family and domain databases

Gene3Di1.10.12.10, 1 hit
InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 enoyl-CoA_hydra_C
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

O07137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDTILVDG YQRVGIITLN RPQALNALNS QMMNEITNAA KELDIDPDVG
60 70 80 90 100
AILITGSPKV FAAGADIKEM ASLTFTDAFD ADFFSAWGKL AAVRTPMIAA
110 120 130 140 150
VAGYALGGGC ELAMMCDLLI AADTAKFGQP EIKLGVLPGM GGSQRLTRAI
160 170 180 190 200
GKAKAMDLIL TGRTIDAAEA ERSGLVSRVV LADDLLPEAK AVATTISQMS
210 220 230 240 250
RSATRMAKEA VNRSFESTLA EGLLHERRLF HSTFVTDDQS EGMAAFIEKR

APQFTHR
Length:257
Mass (Da):27,517
Last modified:July 1, 1997 - v1
Checksum:i25B801EB690BCD00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13803 Genomic DNA Translation: CAA74130.1
AL583925 Genomic DNA Translation: CAC31918.1
PIRiF87209
RefSeqiNP_302555.1, NC_002677.1
WP_010908875.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31918; CAC31918; CAC31918
GeneIDi908604
KEGGimle:ML2402
PATRICifig|272631.5.peg.4621

Similar proteinsi

Entry informationi

Entry nameiECHA8_MYCLE
AccessioniPrimary (citable) accession number: O07137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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