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Protein

1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene

menA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).UniRule annotation

Catalytic activityi

An all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO2.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA)
  2. Demethylmenaquinone methyltransferase (menG)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Menaquinone biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00079; UER00168.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-dihydroxy-2-naphthoate octaprenyltransferaseUniRule annotation (EC:2.5.1.74UniRule annotation)
Short name:
DHNA-octaprenyltransferaseUniRule annotation
Gene namesi
Name:menAUniRule annotation
Ordered Locus Names:ML2406
ORF Names:MLB1306.02c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2406.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalUniRule annotationAdd BLAST21
Transmembranei103 – 123HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei166 – 186HelicalUniRule annotationAdd BLAST21
Transmembranei220 – 240HelicalUniRule annotationAdd BLAST21
Transmembranei272 – 292HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964171 – 2941,4-dihydroxy-2-naphthoate octaprenyltransferaseAdd BLAST294

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2406.

Structurei

3D structure databases

ProteinModelPortaliO07134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MenA family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EIS. Bacteria.
COG1575. LUCA.
HOGENOMiHOG000028298.
KOiK02548.
OMAiTVGKKPY.
OrthoDBiPOG091H02EO.

Family and domain databases

HAMAPiMF_01937. MenA_1. 1 hit.
InterProiIPR004657. MenA.
IPR000537. UbiA_prenyltransferase.
IPR026046. UBIAD1.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF005355. UBIAD1. 1 hit.

Sequencei

Sequence statusi: Complete.

O07134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFAQWISG ARPRTLPNAV APVVAGTGTA AWLHSAVWWK ALLALVVAVA
60 70 80 90 100
LVIGVNYAND YSDGIRGTDD HRAGPMRLVG SRLAFPRSVL TAAVVGLTVS
110 120 130 140 150
TVAGLALALL SAPWLIMVGA TCIAGAWLYT GSSKPYGYKG FGEVAVFVFF
160 170 180 190 200
GLVAVLGTEY TQALRVDWVG LVLAVSTGAL SSSVLVANNL RDIHTDTQSH
210 220 230 240 250
KFTLAVRLGD AHTRQLYQAL LVATGVLTVV LMVATSWCAV GLVATPLALR
260 270 280 290
AMRPVRSGRM GPDLTPVLRD TGLAMVVWAI AVAGALTLAG SVTY
Length:294
Mass (Da):30,671
Last modified:July 1, 1997 - v1
Checksum:iDAC9F77ABD3157E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13803 Genomic DNA. Translation: CAA74132.1.
AL583925 Genomic DNA. Translation: CAC31922.1.
PIRiB87210.
RefSeqiNP_302556.1. NC_002677.1.
WP_010908876.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31922; CAC31922; CAC31922.
GeneIDi908601.
KEGGimle:ML2406.
PATRICi18059429. VBIMycLep78757_4629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13803 Genomic DNA. Translation: CAA74132.1.
AL583925 Genomic DNA. Translation: CAC31922.1.
PIRiB87210.
RefSeqiNP_302556.1. NC_002677.1.
WP_010908876.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO07134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31922; CAC31922; CAC31922.
GeneIDi908601.
KEGGimle:ML2406.
PATRICi18059429. VBIMycLep78757_4629.

Organism-specific databases

LepromaiML2406.

Phylogenomic databases

eggNOGiENOG4105EIS. Bacteria.
COG1575. LUCA.
HOGENOMiHOG000028298.
KOiK02548.
OMAiTVGKKPY.
OrthoDBiPOG091H02EO.

Enzyme and pathway databases

UniPathwayiUPA00079; UER00168.

Family and domain databases

HAMAPiMF_01937. MenA_1. 1 hit.
InterProiIPR004657. MenA.
IPR000537. UbiA_prenyltransferase.
IPR026046. UBIAD1.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF005355. UBIAD1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMENA_MYCLE
AccessioniPrimary (citable) accession number: O07134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.