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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Methylobacillus flagellatus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. no protein annotated in this organism
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:hisC
Synonyms:hisH
OrganismiMethylobacillus flagellatus
Taxonomic identifieri405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesMethylophilaceaeMethylobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001533901 – 368Histidinol-phosphate aminotransferaseAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei228N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO07131.
SMRiO07131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH. Bacteria.
COG0079. LUCA.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01023. HisC_aminotrans_2. 1 hit.
InterProiView protein in InterPro
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00155. Aminotran_1_2. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01141. hisC. 1 hit.
PROSITEiView protein in PROSITE
PS00599. AA_TRANSFER_CLASS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O07131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRLYDFAPS NIRAIAPYQP GKPITELARE MGLKPGVIIK LASNENPLGV
60 70 80 90 100
SPKAYAAMQD ALEDIARYPD GNSFALRDCV CRKFKLQPDQ LVFGNGSNDI
110 120 130 140 150
LELAARAFLT PGTEAVYAQH AFAVYALVTQ ATGASGISVP ARDFGHDLDA
160 170 180 190 200
MLAAITDKTR LFIANPNNPT GTLLSKPALR DFLAKVPRQV LVVLDEAYDE
210 220 230 240 250
YLAAELKSEA FSWLAEFDNL LISRTLSKAY GLAGLRVGFG VTSPGVADLM
260 270 280 290 300
NRVRQPFNVN SVAQAAAVAA LEDDEFVERS YALNQAGMQQ LTEGLARLGL
310 320 330 340 350
SYIPSYGNFV SFHVAQAAEV YQQLLKRGVI VRPVAAYDMP DYLRVSIGLH
360
AENARFLEVL EQILKTRT
Length:368
Mass (Da):40,134
Last modified:July 1, 1997 - v1
Checksum:iC8F47963A732B3AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83322 Genomic DNA. Translation: AAB58526.1.

Similar proteinsi

Entry informationi

Entry nameiHIS8_METFL
AccessioniPrimary (citable) accession number: O07131
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: August 30, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families