ID   FLII_HELPY              Reviewed;         434 AA.
AC   O07025; P94822;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Flagellum-specific ATP synthase;
DE            EC=7.1.2.2;
GN   Name=fliI; OrderedLocusNames=HP_1420;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N6;
RX   PubMed=9231413; DOI=10.1111/j.1574-6968.1997.tb10429.x;
RA   Jenks P.J., Foynes S., Ward S., Wren B.W.;
RT   "A flagellar-specific ATPase (FliI) is necessary for flagellar export in
RT   Helicobacter pylori.";
RL   FEMS Microbiol. Lett. 152:205-211(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Probable catalytic subunit of a protein translocase for
CC       flagellum-specific export, or a proton translocase involved in local
CC       circuits at the flagellum.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC         Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10106};
CC   -!- INTERACTION:
CC       O07025; O25120: HP_0353; NbExp=4; IntAct=EBI-957989, EBI-958087;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000305}.
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DR   EMBL; Y08620; CAA69911.1; -; Genomic_DNA.
DR   EMBL; AE000511; AAD08462.1; -; Genomic_DNA.
DR   PIR; D64697; D64697.
DR   RefSeq; NP_208211.1; NC_000915.1.
DR   RefSeq; WP_001128709.1; NC_018939.1.
DR   AlphaFoldDB; O07025; -.
DR   SMR; O07025; -.
DR   DIP; DIP-3391N; -.
DR   IntAct; O07025; 1.
DR   MINT; O07025; -.
DR   STRING; 85962.HP_1420; -.
DR   PaxDb; 85962-C694_07345; -.
DR   EnsemblBacteria; AAD08462; AAD08462; HP_1420.
DR   KEGG; hpy:HP_1420; -.
DR   PATRIC; fig|85962.47.peg.1524; -.
DR   eggNOG; COG1157; Bacteria.
DR   InParanoid; O07025; -.
DR   OrthoDB; 9801639at2; -.
DR   PhylomeDB; O07025; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045261; C:proton-transporting ATP synthase complex, catalytic core F(1); IBA:GO_Central.
DR   GO; GO:0030257; C:type III protein secretion system complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR   CDD; cd18114; ATP-synt_flagellum-secretory_path_III_C; 1.
DR   CDD; cd01136; ATPase_flagellum-secretory_path_III; 1.
DR   Gene3D; 3.40.50.12240; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR005714; ATPase_T3SS_FliI/YscN.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR040627; T3SS_ATPase_C.
DR   NCBIfam; TIGR01026; fliI_yscN; 1.
DR   PANTHER; PTHR15184; ATP SYNTHASE; 1.
DR   PANTHER; PTHR15184:SF9; SPI-1 TYPE 3 SECRETION SYSTEM ATPASE; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF18269; T3SS_ATPase_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   1: Evidence at protein level;
KW   ATP synthesis; ATP-binding; Bacterial flagellum biogenesis;
KW   Bacterial flagellum protein export; Cytoplasm; Hydrogen ion transport;
KW   Ion transport; Nucleotide-binding; Protein transport; Reference proteome;
KW   Translocase; Transport.
FT   CHAIN           1..434
FT                   /note="Flagellum-specific ATP synthase"
FT                   /id="PRO_0000144696"
FT   BINDING         164..171
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        15
FT                   /note="D -> E (in Ref. 1; CAA69911)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        115
FT                   /note="A -> V (in Ref. 1; CAA69911)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        140
FT                   /note="I -> V (in Ref. 1; CAA69911)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        323
FT                   /note="T -> A (in Ref. 1; CAA69911)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        367
FT                   /note="C -> Y (in Ref. 1; CAA69911)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        424
FT                   /note="T -> Q (in Ref. 1; CAA69911)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   434 AA;  47636 MW;  6F04D67C988B4E22 CRC64;
     MPLKSLKNRL NQHFDLSPRY GSVKKIMPNI VYADGFNPSV GDVVKIEKSD GSECVGMVVV
     AEKEQFGFTP FNFIEGARAG DKVLFLKEGL NFPVGRNLLG RVLNPLGQVI DNKGALDYER
     LAPVITTPIA PLKRGLIDEI FSVGVKSIDG LLTCGKGQKL GIFAGSGVGK STLMGMITRG
     CLAPIKVIAL IGERGREIPE FIEKNLKGDL SSCVLVVATS DDSPLMRKYG AFCAMSVAEY
     FKNQGLDVLF IMDSVTRFAM AQREIGLALG EPPTSKGYPP SALSLLPQLM ERAGKEENKG
     SITAFFSVLV EGDDLSDPIA DQTRSILDGH IVLSRELTDY GIYPPINILN SASRVAKDII
     SESQNLCARK FRRLYALLKE NEMLIRIGSY QMGNDKELDE AIKKKALMEQ FLAQDENALQ
     PFETSFQQLE EILR
//