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O07025

- FLII_HELPY

UniProt

O07025 - FLII_HELPY

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Protein
Flagellum-specific ATP synthase
Gene
fliI, HP_1420
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi164 – 1718ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: InterPro
  3. protein binding Source: IntAct

GO - Biological processi

  1. ATP biosynthetic process Source: UniProtKB-KW
  2. protein secretion by the type III secretion system Source: InterPro
  3. proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Bacterial flagellum biogenesis, Bacterial flagellum protein export, Hydrogen ion transport, Ion transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1420-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellum-specific ATP synthase (EC:3.6.3.14)
Gene namesi
Name:fliI
Ordered Locus Names:HP_1420
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. type III protein secretion system complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Flagellum-specific ATP synthase
PRO_0000144696Add
BLAST

Proteomic databases

PRIDEiO07025.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fliHO251204EBI-957989,EBI-958087

Protein-protein interaction databases

DIPiDIP-3391N.
IntActiO07025. 1 interaction.
MINTiMINT-185321.
STRINGi85962.HP1420.

Structurei

3D structure databases

ProteinModelPortaliO07025.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1157.
KOiK02412.
OMAiGQRMGIM.
OrthoDBiEOG6W9X53.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR018538. HAS-barrel.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF9. PTHR15184:SF9. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF09378. HAS-barrel. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01026. fliI_yscN. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07025-1 [UniParc]FASTAAdd to Basket

« Hide

MPLKSLKNRL NQHFDLSPRY GSVKKIMPNI VYADGFNPSV GDVVKIEKSD    50
GSECVGMVVV AEKEQFGFTP FNFIEGARAG DKVLFLKEGL NFPVGRNLLG 100
RVLNPLGQVI DNKGALDYER LAPVITTPIA PLKRGLIDEI FSVGVKSIDG 150
LLTCGKGQKL GIFAGSGVGK STLMGMITRG CLAPIKVIAL IGERGREIPE 200
FIEKNLKGDL SSCVLVVATS DDSPLMRKYG AFCAMSVAEY FKNQGLDVLF 250
IMDSVTRFAM AQREIGLALG EPPTSKGYPP SALSLLPQLM ERAGKEENKG 300
SITAFFSVLV EGDDLSDPIA DQTRSILDGH IVLSRELTDY GIYPPINILN 350
SASRVAKDII SESQNLCARK FRRLYALLKE NEMLIRIGSY QMGNDKELDE 400
AIKKKALMEQ FLAQDENALQ PFETSFQQLE EILR 434
Length:434
Mass (Da):47,636
Last modified:November 1, 1997 - v2
Checksum:i6F04D67C988B4E22
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151D → E in CAA69911. 1 Publication
Sequence conflicti115 – 1151A → V in CAA69911. 1 Publication
Sequence conflicti140 – 1401I → V in CAA69911. 1 Publication
Sequence conflicti323 – 3231T → A in CAA69911. 1 Publication
Sequence conflicti367 – 3671C → Y in CAA69911. 1 Publication
Sequence conflicti424 – 4241T → Q in CAA69911. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08620 Genomic DNA. Translation: CAA69911.1.
AE000511 Genomic DNA. Translation: AAD08462.1.
PIRiD64697.
RefSeqiNP_208211.1. NC_000915.1.
YP_006935343.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08462; AAD08462; HP_1420.
GeneIDi13870632.
899875.
KEGGiheo:C694_07345.
hpy:HP1420.
PATRICi20594239. VBIHelPyl33062_1489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08620 Genomic DNA. Translation: CAA69911.1 .
AE000511 Genomic DNA. Translation: AAD08462.1 .
PIRi D64697.
RefSeqi NP_208211.1. NC_000915.1.
YP_006935343.1. NC_018939.1.

3D structure databases

ProteinModelPortali O07025.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3391N.
IntActi O07025. 1 interaction.
MINTi MINT-185321.
STRINGi 85962.HP1420.

Proteomic databases

PRIDEi O07025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08462 ; AAD08462 ; HP_1420 .
GeneIDi 13870632.
899875.
KEGGi heo:C694_07345.
hpy:HP1420.
PATRICi 20594239. VBIHelPyl33062_1489.

Phylogenomic databases

eggNOGi COG1157.
KOi K02412.
OMAi GQRMGIM.
OrthoDBi EOG6W9X53.

Enzyme and pathway databases

BioCyci HPY:HP1420-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR018538. HAS-barrel.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR15184:SF9. PTHR15184:SF9. 1 hit.
Pfami PF00006. ATP-synt_ab. 1 hit.
PF09378. HAS-barrel. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01026. fliI_yscN. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A flagellar-specific ATPase (FliI) is necessary for flagellar export in Helicobacter pylori."
    Jenks P.J., Foynes S., Ward S., Wren B.W.
    FEMS Microbiol. Lett. 152:205-211(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: N6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiFLII_HELPY
AccessioniPrimary (citable) accession number: O07025
Secondary accession number(s): P94822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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