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O07025

- FLII_HELPY

UniProt

O07025 - FLII_HELPY

Protein

Flagellum-specific ATP synthase

Gene

fliI

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.

    Catalytic activityi

    ATP + H2O + H+(In) = ADP + phosphate + H+(Out).PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi164 – 1718ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. ATP biosynthetic process Source: UniProtKB-KW
    2. protein secretion by the type III secretion system Source: InterPro
    3. proton transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    ATP synthesis, Bacterial flagellum biogenesis, Bacterial flagellum protein export, Hydrogen ion transport, Ion transport, Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1420-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Flagellum-specific ATP synthase (EC:3.6.3.14)
    Gene namesi
    Name:fliI
    Ordered Locus Names:HP_1420
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. type III protein secretion system complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Flagellum-specific ATP synthasePRO_0000144696Add
    BLAST

    Proteomic databases

    PRIDEiO07025.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    fliHO251204EBI-957989,EBI-958087

    Protein-protein interaction databases

    DIPiDIP-3391N.
    IntActiO07025. 1 interaction.
    MINTiMINT-185321.
    STRINGi85962.HP1420.

    Structurei

    3D structure databases

    ProteinModelPortaliO07025.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.Curated

    Phylogenomic databases

    eggNOGiCOG1157.
    KOiK02412.
    OMAiGQRMGIM.
    OrthoDBiEOG6W9X53.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR020003. ATPase_a/bsu_AS.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR005714. ATPase_T3SS_FliI/YscN.
    IPR018538. HAS-barrel.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR15184:SF9. PTHR15184:SF9. 1 hit.
    PfamiPF00006. ATP-synt_ab. 1 hit.
    PF09378. HAS-barrel. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01026. fliI_yscN. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O07025-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLKSLKNRL NQHFDLSPRY GSVKKIMPNI VYADGFNPSV GDVVKIEKSD    50
    GSECVGMVVV AEKEQFGFTP FNFIEGARAG DKVLFLKEGL NFPVGRNLLG 100
    RVLNPLGQVI DNKGALDYER LAPVITTPIA PLKRGLIDEI FSVGVKSIDG 150
    LLTCGKGQKL GIFAGSGVGK STLMGMITRG CLAPIKVIAL IGERGREIPE 200
    FIEKNLKGDL SSCVLVVATS DDSPLMRKYG AFCAMSVAEY FKNQGLDVLF 250
    IMDSVTRFAM AQREIGLALG EPPTSKGYPP SALSLLPQLM ERAGKEENKG 300
    SITAFFSVLV EGDDLSDPIA DQTRSILDGH IVLSRELTDY GIYPPINILN 350
    SASRVAKDII SESQNLCARK FRRLYALLKE NEMLIRIGSY QMGNDKELDE 400
    AIKKKALMEQ FLAQDENALQ PFETSFQQLE EILR 434
    Length:434
    Mass (Da):47,636
    Last modified:November 1, 1997 - v2
    Checksum:i6F04D67C988B4E22
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151D → E in CAA69911. (PubMed:9231413)Curated
    Sequence conflicti115 – 1151A → V in CAA69911. (PubMed:9231413)Curated
    Sequence conflicti140 – 1401I → V in CAA69911. (PubMed:9231413)Curated
    Sequence conflicti323 – 3231T → A in CAA69911. (PubMed:9231413)Curated
    Sequence conflicti367 – 3671C → Y in CAA69911. (PubMed:9231413)Curated
    Sequence conflicti424 – 4241T → Q in CAA69911. (PubMed:9231413)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08620 Genomic DNA. Translation: CAA69911.1.
    AE000511 Genomic DNA. Translation: AAD08462.1.
    PIRiD64697.
    RefSeqiNP_208211.1. NC_000915.1.
    YP_006935343.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08462; AAD08462; HP_1420.
    GeneIDi13870632.
    899875.
    KEGGiheo:C694_07345.
    hpy:HP1420.
    PATRICi20594239. VBIHelPyl33062_1489.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08620 Genomic DNA. Translation: CAA69911.1 .
    AE000511 Genomic DNA. Translation: AAD08462.1 .
    PIRi D64697.
    RefSeqi NP_208211.1. NC_000915.1.
    YP_006935343.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O07025.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3391N.
    IntActi O07025. 1 interaction.
    MINTi MINT-185321.
    STRINGi 85962.HP1420.

    Proteomic databases

    PRIDEi O07025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08462 ; AAD08462 ; HP_1420 .
    GeneIDi 13870632.
    899875.
    KEGGi heo:C694_07345.
    hpy:HP1420.
    PATRICi 20594239. VBIHelPyl33062_1489.

    Phylogenomic databases

    eggNOGi COG1157.
    KOi K02412.
    OMAi GQRMGIM.
    OrthoDBi EOG6W9X53.

    Enzyme and pathway databases

    BioCyci HPY:HP1420-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR020003. ATPase_a/bsu_AS.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR005714. ATPase_T3SS_FliI/YscN.
    IPR018538. HAS-barrel.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR15184:SF9. PTHR15184:SF9. 1 hit.
    Pfami PF00006. ATP-synt_ab. 1 hit.
    PF09378. HAS-barrel. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01026. fliI_yscN. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A flagellar-specific ATPase (FliI) is necessary for flagellar export in Helicobacter pylori."
      Jenks P.J., Foynes S., Ward S., Wren B.W.
      FEMS Microbiol. Lett. 152:205-211(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: N6.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiFLII_HELPY
    AccessioniPrimary (citable) accession number: O07025
    Secondary accession number(s): P94822
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3