Flagellum-specific ATP synthase - Helicobacter pylori (strain ATCC 700392 / 26695)

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O07025 (FLII_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Flagellum-specific ATP synthase
EC=3.6.3.14

Gene names

Name:	fliI
Ordered Locus Names:	HP_1420

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.
Catalytic activity	ATP + H₂O + H⁺(In) = ADP + phosphate + H⁺(Out).
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Bacterial flagellum biogenesis Bacterial flagellum protein export Hydrogen ion transport Ion transport Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW flagellum organization Inferred from electronic annotation. Source: UniProtKB-KW protein secretion by the type III secretion system Inferred from electronic annotation. Source: InterPro proton transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell type III protein secretion system complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
fliH	O25120	3	EBI-957989,EBI-958087

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 434

434

Flagellum-specific ATP synthase

PRO_0000144696

Regions

Nucleotide binding

164 – 171

ATP Potential

Experimental info

Sequence conflict

D → E in CAA69911. Ref.1

Sequence conflict

115

A → V in CAA69911. Ref.1

Sequence conflict

140

I → V in CAA69911. Ref.1

Sequence conflict

323

T → A in CAA69911. Ref.1

Sequence conflict

367

C → Y in CAA69911. Ref.1

Sequence conflict

424

T → Q in CAA69911. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O07025 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 6F04D67C988B4E22
Show »

FASTA

434

47,636

        10         20         30         40         50         60 
MPLKSLKNRL NQHFDLSPRY GSVKKIMPNI VYADGFNPSV GDVVKIEKSD GSECVGMVVV 

        70         80         90        100        110        120 
AEKEQFGFTP FNFIEGARAG DKVLFLKEGL NFPVGRNLLG RVLNPLGQVI DNKGALDYER 

       130        140        150        160        170        180 
LAPVITTPIA PLKRGLIDEI FSVGVKSIDG LLTCGKGQKL GIFAGSGVGK STLMGMITRG 

       190        200        210        220        230        240 
CLAPIKVIAL IGERGREIPE FIEKNLKGDL SSCVLVVATS DDSPLMRKYG AFCAMSVAEY 

       250        260        270        280        290        300 
FKNQGLDVLF IMDSVTRFAM AQREIGLALG EPPTSKGYPP SALSLLPQLM ERAGKEENKG 

       310        320        330        340        350        360 
SITAFFSVLV EGDDLSDPIA DQTRSILDGH IVLSRELTDY GIYPPINILN SASRVAKDII 

       370        380        390        400        410        420 
SESQNLCARK FRRLYALLKE NEMLIRIGSY QMGNDKELDE AIKKKALMEQ FLAQDENALQ 

       430 
PFETSFQQLE EILR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A flagellar-specific ATPase (FliI) is necessary for flagellar export in Helicobacter pylori." Jenks P.J., Foynes S., Ward S., Wren B.W. FEMS Microbiol. Lett. 152:205-211(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: N6.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08620 Genomic DNA. Translation: CAA69911.1. AE000511 Genomic DNA. Translation: AAD08462.1.
PIR	D64697.
RefSeq	NP_208211.1. NC_000915.1. YP_006935343.1. NC_018939.1.
3D structure databases
ProteinModelPortal	O07025.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3391N.
IntAct	O07025. 1 interaction.
MINT	MINT-185321.
STRING	85962.HP1420.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD08462; AAD08462; HP_1420.
GeneID	13870632. 899875.
KEGG	heo:C694_07345. hpy:HP1420.
PATRIC	20594239. VBIHelPyl33062_1489.
Phylogenomic databases
eggNOG	COG1157.
KO	K02412.
OMA	LQPFEQS.
ProtClustDB	PRK08472.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR020003. ATPase_a/bsu_AS. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. IPR005714. ATPase_T3SS_FliI/YscN. IPR018538. HAS-barrel. [Graphical view]
PANTHER	PTHR15184:SF9. PTHR15184:SF9. 1 hit.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF09378. HAS-barrel. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01026. fliI_yscN. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FLII_HELPY

Accession

Primary (citable) accession number: O07025
Secondary accession number(s): P94822

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents