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Protein

Flagellum-specific ATP synthase

Gene

fliI

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi164 – 1718ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP biosynthetic process Source: UniProtKB-KW
  2. bacterial-type flagellum organization Source: UniProtKB-KW
  3. protein secretion by the type III secretion system Source: InterPro
  4. proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Bacterial flagellum biogenesis, Bacterial flagellum protein export, Hydrogen ion transport, Ion transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1420-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellum-specific ATP synthase (EC:3.6.3.14)
Gene namesi
Name:fliI
Ordered Locus Names:HP_1420
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. type III protein secretion system complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Flagellum-specific ATP synthasePRO_0000144696Add
BLAST

Proteomic databases

PRIDEiO07025.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fliHO251204EBI-957989,EBI-958087

Protein-protein interaction databases

DIPiDIP-3391N.
IntActiO07025. 1 interaction.
MINTiMINT-185321.
STRINGi85962.HP1420.

Structurei

3D structure databases

ProteinModelPortaliO07025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiCOG1157.
KOiK02412.
OMAiQAQKFKQ.
OrthoDBiEOG6W9X53.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR018538. HAS-barrel.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF9. PTHR15184:SF9. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF09378. HAS-barrel. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01026. fliI_yscN. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O07025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLKSLKNRL NQHFDLSPRY GSVKKIMPNI VYADGFNPSV GDVVKIEKSD
60 70 80 90 100
GSECVGMVVV AEKEQFGFTP FNFIEGARAG DKVLFLKEGL NFPVGRNLLG
110 120 130 140 150
RVLNPLGQVI DNKGALDYER LAPVITTPIA PLKRGLIDEI FSVGVKSIDG
160 170 180 190 200
LLTCGKGQKL GIFAGSGVGK STLMGMITRG CLAPIKVIAL IGERGREIPE
210 220 230 240 250
FIEKNLKGDL SSCVLVVATS DDSPLMRKYG AFCAMSVAEY FKNQGLDVLF
260 270 280 290 300
IMDSVTRFAM AQREIGLALG EPPTSKGYPP SALSLLPQLM ERAGKEENKG
310 320 330 340 350
SITAFFSVLV EGDDLSDPIA DQTRSILDGH IVLSRELTDY GIYPPINILN
360 370 380 390 400
SASRVAKDII SESQNLCARK FRRLYALLKE NEMLIRIGSY QMGNDKELDE
410 420 430
AIKKKALMEQ FLAQDENALQ PFETSFQQLE EILR
Length:434
Mass (Da):47,636
Last modified:November 1, 1997 - v2
Checksum:i6F04D67C988B4E22
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151D → E in CAA69911 (PubMed:9231413).Curated
Sequence conflicti115 – 1151A → V in CAA69911 (PubMed:9231413).Curated
Sequence conflicti140 – 1401I → V in CAA69911 (PubMed:9231413).Curated
Sequence conflicti323 – 3231T → A in CAA69911 (PubMed:9231413).Curated
Sequence conflicti367 – 3671C → Y in CAA69911 (PubMed:9231413).Curated
Sequence conflicti424 – 4241T → Q in CAA69911 (PubMed:9231413).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08620 Genomic DNA. Translation: CAA69911.1.
AE000511 Genomic DNA. Translation: AAD08462.1.
PIRiD64697.
RefSeqiNP_208211.1. NC_000915.1.
YP_006935343.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08462; AAD08462; HP_1420.
GeneIDi899875.
KEGGiheo:C694_07345.
hpy:HP1420.
PATRICi20594239. VBIHelPyl33062_1489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08620 Genomic DNA. Translation: CAA69911.1.
AE000511 Genomic DNA. Translation: AAD08462.1.
PIRiD64697.
RefSeqiNP_208211.1. NC_000915.1.
YP_006935343.1. NC_018939.1.

3D structure databases

ProteinModelPortaliO07025.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3391N.
IntActiO07025. 1 interaction.
MINTiMINT-185321.
STRINGi85962.HP1420.

Proteomic databases

PRIDEiO07025.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08462; AAD08462; HP_1420.
GeneIDi899875.
KEGGiheo:C694_07345.
hpy:HP1420.
PATRICi20594239. VBIHelPyl33062_1489.

Phylogenomic databases

eggNOGiCOG1157.
KOiK02412.
OMAiQAQKFKQ.
OrthoDBiEOG6W9X53.

Enzyme and pathway databases

BioCyciHPY:HP1420-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR018538. HAS-barrel.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF9. PTHR15184:SF9. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF09378. HAS-barrel. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01026. fliI_yscN. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A flagellar-specific ATPase (FliI) is necessary for flagellar export in Helicobacter pylori."
    Jenks P.J., Foynes S., Ward S., Wren B.W.
    FEMS Microbiol. Lett. 152:205-211(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: N6.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiFLII_HELPY
AccessioniPrimary (citable) accession number: O07025
Secondary accession number(s): P94822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 1, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.