Reviewed, UniProtKB/Swiss-Prot O07014 (RSBP_BACSU)

Names and origin

Protein names

Recommended name:
    Phosphoserine phosphatase rsbP
    EC=3.1.3.3

Gene names

Name:	rsbP
Synonyms:	yvfP
Ordered Locus Names:	BSU34110

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Positive regulator of sigma-B activity. Dephosphorylates rsbV in response to energy stress.
Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor	Manganese.
Induction	Induced by entry into stationary phase, but not by carbon and energy starvation.
Domain	The PAS domain may participate in sensing the overall energy level of the cell and communicate this information to the phosphatase domain.
Sequence similarities	Contains 1 PAS (PER-ARNT-SIM) domain. Contains 1 PP2C-like domain.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 403	403	Phosphoserine phosphatase rsbP		PRO_0000057789
Regions
	Domain	1 – 42	42	PAS

Sequences

	Sequence		Length	Mass (Da)
	O07014-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 104A3651F7FC7962	FASTA	403	46,030
	10 20 30 40 50 60 MDKQLNDAPC GFLALSEEGS IIAANRTLIK ILDYEPEQVI GQHMNMMLTI PAQLFCQLYF 70 80 90 100 110 120 FPLLKLEHHI EEIYISLKAR DGEEIPVLIN AIARHDSGAS VFDCVLIPMR KRNEYENELL 130 140 150 160 170 180 IARNEAQEAL LAKQKANAEL EIALETLKAK QEELLEINKQ NQQFKLNTKR ELELARKIQK 190 200 210 220 230 240 NSLTEPIVND QVQIDSYYNA SSELSGDLYG YYQIDEHRYG IIILDVMGHG ISSALITMSL 250 260 270 280 290 300 HPLFQRQITQ GLSPVKVMKE LDRHLHSLFQ NDEEARHYCT AIYLEIDIAR QRIDYVNAGH 310 320 330 340 350 360 PPALWQDDSG TQHLLHATSP PIGMFEDLEF QSSSLSYTED GRLLLYTDGV MDPTASCYLF 370 380 390 400 DLLKDHPDSP IADLKEKILT SLQHQKEAHH KSDDECFILV DVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Denizot F. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"A PP2C phosphatase containing a PAS domain is required to convey signals of energy stress to the sigmaB transcription factor of Bacillus subtilis." Vijay K., Brody M.S., Fredlund E., Price C.W. Mol. Microbiol. 35:180-188(2000) [PubMed: 10632888] [Abstract] Cited for: CHARACTERIZATION. Strain: 168 / Marburg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z94043 Genomic DNA. Translation: CAB08010.1. AL009126 Genomic DNA. Translation: CAB15416.1.
PIR	G70038.
RefSeq	NP_391291.1.
3D structure databases
ModBase	Search...
Protein family/group databases
PptaseDB	P3D0412162.
Genome annotation databases
GeneID	936673.
GenomeReviews	Gene locus BSU34110 in contig AL009126_GR.
KEGG	bsu:BSU34110.
NMPDR	fig|224308.1.peg.3417.
Organism-specific databases
SubtiList	BG12441. rsbP. [Micado]
CMR	Search...
Phylogenomic databases
OMA	HETHFAP.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU3408-MON.
BRENDA	3.1.3.3. 150.
Family and domain databases
InterPro	IPR001610. PAC. IPR000014. PAS. IPR013767. PAS_fold. IPR001932. PP2C-related. IPR010822. Spore_II_E_C. [Graphical view]
Pfam	PF00989. PAS. 1 hit. PF07228. SpoIIE. 1 hit. [Graphical view]
SMART	SM00086. PAC. 1 hit. SM00091. PAS. 1 hit. SM00331. PP2C_SIG. 1 hit. [Graphical view]
TIGRFAMs	TIGR00229. sensory_box. 1 hit.
PROSITE	PS50112. PAS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSBP_BACSU

Accession

Primary (citable) accession number: O07014

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 1, 1997
Last modified:	November 3, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)