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Protein

HPr-like protein Crh

Gene

crh

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Along with seryl-phosphorylated HPr, phosphorylated Crh is implicated in carbon catabolite repression (CCR) of levanase, inositol dehydrogenase, and beta-xylosidase. Exerts its effect on CCR by interacting with CcpA.2 Publications

Enzyme and pathway databases

BioCyciBSUB:BSU34740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HPr-like protein Crh
Alternative name(s):
Catabolite repression HPr
Gene namesi
Name:crh
Synonyms:yvcM
Ordered Locus Names:BSU34740
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi15 – 151Q → H: Cannot fulfill its catalytic role within PTS transport. Does not affect dimerization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585HPr-like protein CrhPRO_0000107899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461Phosphoserine; by HPrK/PPROSITE-ProRule annotation2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO06976.

PTM databases

iPTMnetiO06976.

Interactioni

Subunit structurei

Mixture of monomers and homodimers. Interacts with CcpA as a monomer.2 Publications

Protein-protein interaction databases

IntActiO06976. 2 interactions.
STRINGi224308.Bsubs1_010100018816.

Structurei

Secondary structure

1
85
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Beta strandi12 – 143Combined sources
Helixi16 – 2611Combined sources
Beta strandi29 – 379Combined sources
Beta strandi40 – 434Combined sources
Helixi47 – 526Combined sources
Beta strandi60 – 678Combined sources
Helixi70 – 8112Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K1CNMR-A2-85[»]
1MO1X-ray1.80A/B/C/D1-85[»]
1MU4X-ray1.80A/B1-85[»]
1ZVVX-ray2.98J/P/W1-85[»]
2AK7X-ray2.00A/B1-85[»]
2RLZNMR-A/B1-85[»]
ProteinModelPortaliO06976.
SMRiO06976. Positions 1-85.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO06976.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8585HPrPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HPr family.Curated
Contains 1 HPr domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105KRI. Bacteria.
COG1925. LUCA.
HOGENOMiHOG000278399.
InParanoidiO06976.
KOiK11184.
OMAiFVQEANK.
PhylomeDBiO06976.

Family and domain databases

CDDicd00367. PTS-HPr_like. 1 hit.
Gene3Di3.30.1340.10. 1 hit.
InterProiIPR000032. HPr-like.
IPR002114. PTS_HPr_Ser_P_site.
[Graphical view]
PfamiPF00381. PTS-HPr. 1 hit.
[Graphical view]
PRINTSiPR00107. PHOSPHOCPHPR.
SUPFAMiSSF55594. SSF55594. 1 hit.
TIGRFAMsiTIGR01003. PTS_HPr_family. 1 hit.
PROSITEiPS51350. PTS_HPR_DOM. 1 hit.
PS00589. PTS_HPR_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O06976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQKVEVRL KTGLQARPAA LFVQEANRFT SDVFLEKDGK KVNAKSIMGL
60 70 80
MSLAVSTGTE VTLIAQGEDE QEALEKLAAY VQEEV
Length:85
Mass (Da):9,327
Last modified:July 1, 1997 - v1
Checksum:i1801425F51B9B3F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z94043 Genomic DNA. Translation: CAB08060.1.
AL009126 Genomic DNA. Translation: CAB15479.1.
PIRiD69607.
RefSeqiNP_391354.1. NC_000964.3.
WP_003219835.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15479; CAB15479; BSU34740.
GeneIDi11241079.
938474.
KEGGibsu:BSU34740.
PATRICi18978954. VBIBacSub10457_3639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z94043 Genomic DNA. Translation: CAB08060.1.
AL009126 Genomic DNA. Translation: CAB15479.1.
PIRiD69607.
RefSeqiNP_391354.1. NC_000964.3.
WP_003219835.1. NZ_JNCM01000033.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K1CNMR-A2-85[»]
1MO1X-ray1.80A/B/C/D1-85[»]
1MU4X-ray1.80A/B1-85[»]
1ZVVX-ray2.98J/P/W1-85[»]
2AK7X-ray2.00A/B1-85[»]
2RLZNMR-A/B1-85[»]
ProteinModelPortaliO06976.
SMRiO06976. Positions 1-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO06976. 2 interactions.
STRINGi224308.Bsubs1_010100018816.

PTM databases

iPTMnetiO06976.

Proteomic databases

PaxDbiO06976.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15479; CAB15479; BSU34740.
GeneIDi11241079.
938474.
KEGGibsu:BSU34740.
PATRICi18978954. VBIBacSub10457_3639.

Phylogenomic databases

eggNOGiENOG4105KRI. Bacteria.
COG1925. LUCA.
HOGENOMiHOG000278399.
InParanoidiO06976.
KOiK11184.
OMAiFVQEANK.
PhylomeDBiO06976.

Enzyme and pathway databases

BioCyciBSUB:BSU34740-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO06976.

Family and domain databases

CDDicd00367. PTS-HPr_like. 1 hit.
Gene3Di3.30.1340.10. 1 hit.
InterProiIPR000032. HPr-like.
IPR002114. PTS_HPr_Ser_P_site.
[Graphical view]
PfamiPF00381. PTS-HPr. 1 hit.
[Graphical view]
PRINTSiPR00107. PHOSPHOCPHPR.
SUPFAMiSSF55594. SSF55594. 1 hit.
TIGRFAMsiTIGR01003. PTS_HPr_family. 1 hit.
PROSITEiPS51350. PTS_HPR_DOM. 1 hit.
PS00589. PTS_HPR_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRH_BACSU
AccessioniPrimary (citable) accession number: O06976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Not phosphorylated by PEP and by enzyme I.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.