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Protein

Gluconeogenesis factor

Gene

mgfK

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for morphogenesis under gluconeogenic growth conditions. Required, in gluconeogenic growth conditions, for the correct localization of PBP1 and hence for displaying a normal rod shape.UniRule annotation2 Publications

Miscellaneous

When bacteria are grown on a gluconeogenic carbon source, overproduction can restore a normal rod-shaped morphology in a mreB mutant by rescuing the PBP1 localization.1 Publication

Enzyme and pathway databases

BioCyciBSUB:BSU34760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Gluconeogenesis factorUniRule annotation
Gene namesi
Name:mgfK
Synonyms:yvcK
Ordered Locus Names:BSU34760
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication
  • Note: Organized into coiled helical structures extending from one pole to the other. Localization does not require MreB.

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Deletion leads to growth defects when cells are grown on minimal medium containing ribose, gluconate, citrate, fumarate or succinate, but does not affect growth and morphology on minimal medium containing glycolytic substrates such as glucose, sucrose or glycerol. Mutants exhibit media-dependent filamentous or L-shape-like aberrant morphologies.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001078041 – 317Gluconeogenesis factorAdd BLAST317

Proteomic databases

PaxDbiO06974.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100018826.

Structurei

3D structure databases

ProteinModelPortaliO06974.
SMRiO06974.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gluconeogenesis factor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHW. Bacteria.
COG0391. LUCA.
HOGENOMiHOG000072685.
InParanoidiO06974.
OMAiLGPGSWY.
PhylomeDBiO06974.

Family and domain databases

HAMAPiMF_00973. Gluconeogen_factor. 1 hit.
InterProiView protein in InterPro
IPR002882. CofD/UPF0052.
IPR010119. Gluconeogen_factor.
PANTHERiPTHR30135. PTHR30135. 1 hit.
PfamiView protein in Pfam
PF01933. UPF0052. 1 hit.
TIGRFAMsiTIGR01826. CofD_related. 1 hit.

Sequencei

Sequence statusi: Complete.

O06974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQKPKIAIF GGGTGLSVLL RGLKHKPVDI TAIVTVADDG GSSGRLRNEL
60 70 80 90 100
KIPPPGDIRN VLAALSDVEP LVEDLFQHRF NKGNDLTGHS LGNLILAAMT
110 120 130 140 150
NITGDFFHAV TEMSKVLNVR GKVLPAANAS VVLHAEMEDG RVVSGESTIP
160 170 180 190 200
EYGQRIKRVF LTPEQIDPLP ETIDVIREAD LIIIGPGSLY TSILPNLLVP
210 220 230 240 250
KIGEEVIKAP AKKVYICNVM TQPGETLHYT AADHVKALNQ HMGCGFIDTI
260 270 280 290 300
LVNSEDIPDE IKRKYEMESA RPVDFDIEEL KAMGLEVIRD QIVTYKNDVI
310
RHDTHKVASL LVDLLKE
Length:317
Mass (Da):34,687
Last modified:July 1, 1997 - v1
Checksum:i6086D29117392CCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z94043 Genomic DNA. Translation: CAB08058.1.
AL009126 Genomic DNA. Translation: CAB15481.2.
PIRiA70032.
RefSeqiNP_391356.2. NC_000964.3.
WP_003244450.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15481; CAB15481; BSU34760.
GeneIDi936527.
KEGGibsu:BSU34760.
PATRICifig|224308.179.peg.3764.

Similar proteinsi

Entry informationi

Entry nameiGNGF_BACSU
AccessioniPrimary (citable) accession number: O06974
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: June 7, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries