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O06961 (TDCD_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Propionate kinase
EC=2.7.2.15
Gene names
Name:tdcD
Synonyms:oxd-2
Ordered Locus Names:STM3242
OrganismSalmonella typhimurium
Taxonomic identifier90371 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_01881

ATP + acetate = ADP + acetyl phosphate. HAMAP MF_01881

Pathway

Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 4/4. HAMAP MF_01881

Sequence similarities

Belongs to the acetokinase family. TdcD subfamily.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processorganic acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

propionate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Propionate kinase HAMAP MF_01881
PRO_0000107656

Experimental info

Sequence conflict135 – 1428AVRQVAVF → GRASGGGI in AAB53419. Ref.1

Secondary structure

1 .................................................................... 402
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O06961 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: EF387E43054FCAB3

FASTA40243,718
        10         20         30         40         50         60 
MNEFPVVLVI NCGSSSIKFS VLDVATCDVL MAGIADGMNT ENAFLSINGD KPINLAHSNY 

        70         80         90        100        110        120 
EDALKAIAFE LEKRDLTDSV ALIGHRIAHG GELFTQSVII TDEIIDNIRR VSPLAPLHNY 

       130        140        150        160        170        180 
ANLSGIDAAR HLFPAVRQVA VFDTSFHQTL APEAYLYGLP WEYFSSLGVR RYGFHGTSHR 

       190        200        210        220        230        240 
YVSRRAYELL DLDEKDSGLI VAHLGNGASI CAVRNGQSVD TSMGMTPLEG LMMGTRSGDV 

       250        260        270        280        290        300 
DFGAMAWIAK ETGQTLSDLE RVVNKESGLL GISGLSSDLR VLEKAWHEGH ERARLAIKTF 

       310        320        330        340        350        360 
VHRIARHIAG HAASLHRLDG IIFTGGIGEN SVLIRQLVIE HLGVLGLTLD VEMNKQPNSH 

       370        380        390        400 
GERIISANPS QVICAVIPTN EEKMIALDAI HLGNVKAPVE FA

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a group of anaerobically induced, fnr-dependent genes of Salmonella typhimurium."
Wei Y., Miller C.G.
J. Bacteriol. 181:6092-6097(1999) [PubMed: 10498722] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed: 11677609] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U89718 Genomic DNA. Translation: AAB53419.1.
AE006468 Genomic DNA. Translation: AAL22115.1.
RefSeqNP_462156.1. NC_003197.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1X3MX-ray2.20A2-402[»]
1X3NX-ray2.30A2-402[»]
2E1YX-ray2.60A2-402[»]
2E1ZX-ray1.98A2-402[»]
2E20X-ray2.40A2-402[»]
ProteinModelPortalO06961.
SMRO06961. Positions 4-397.
ModBaseSearch...

Proteomic databases

PRIDEO06961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1254765.
GenomeReviewsGene locus STM3242 in contig AE006468_GR.
KEGGstm:STM3242.
NMPDRfig|99287.1.peg.3132.
PATRIC32385265. VBISalEnt20916_3438.

Phylogenomic databases

HOGENOMHBG285863.
OMAERMINHA.
ProtClustDBPRK12379.

Enzyme and pathway databases

BioCycSTYP99287:STM3242-MONOMER.
BRENDA2.7.2.15. 5542.

Family and domain databases

HAMAPMF_01881. Propion_kin_subfam1.
[Tree]
InterProIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
IPR024917. Propionate_kinase.
[Graphical view]
KOK00932.
PANTHERPTHR21060. Acetate_kin. 1 hit.
PTHR21060:SF9. PTHR21060:SF9. 1 hit.
PfamPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSPR00471. ACETATEKNASE.
TIGRFAMsTIGR00016. AckA. 1 hit.
PROSITEPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTDCD_SALTY
AccessionPrimary (citable) accession number: O06961
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2002
Last modified: January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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