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Protein

Malonyl-S-ACP:biotin-protein carboxyltransferase MADC

Gene

madC

Organism
Malonomonas rubra
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Gamma subunit of the biotin-dependent malonate decarboxylase multienzyme complex (EC 4.1.1.89). The two subunits MADC and MADD are required for the transfer of the malonate carboxy group from the acyl-carrier protein (ACP) to the prosthetic group of the biotin carrier MADF. Required for the regeneration of ACP.

Catalytic activityi

A malonyl-[acyl-carrier protein] + a biotinyl-[protein] = an acetyl-[acyl-carrier protein] + a carboxybiotinyl-[protein].

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14255.

Protein family/group databases

TCDBi3.B.1.1.4. the na(+)-transporting carboxylic acid decarboxylase (nat-dc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-S-ACP:biotin-protein carboxyltransferase MADC (EC:2.1.3.10)
Gene namesi
Name:madC
OrganismiMalonomonas rubra
Taxonomic identifieri57040 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesDesulfuromonadaceaeMalonomonas

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_50001452532 – 318Malonyl-S-ACP:biotin-protein carboxyltransferase MADCAdd BLAST317

Structurei

3D structure databases

ProteinModelPortaliO06926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 257CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST256

Phylogenomic databases

KOiK20510.

Family and domain databases

InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
IPR017556. Malonate_beta.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR03133. malonate_beta. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O06926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKWTELQDK SFLEATARER AVGIVDEGTF TEFCGPFDKI YSPHLPLMGE
60 70 80 90 100
AIEYDDGLVA GVGKIGKKPI FVISQEGRFI GGSIGEVSGA KMVKTIQLAS
110 120 130 140 150
DLYEEMVSEK PDLPEEMRPA VVISFETGGV RLHEANAGLL AHAEVMDQIQ
160 170 180 190 200
NCRGRVPIIS LIGSRVGCFG GMGFVAAATD VIIMSQFGRL GLTGPEVIEQ
210 220 230 240 250
EMGKDEFDAS DRALVYRTTG GKHKYIIGDC NYLAADSIRS FRETTTAVLQ
260 270 280 290 300
KPMEEIETFR RIGSMEKIKE QIELVKLSVS LKPKDSMDVW AHAGNENPES
310
LINMTLDEFL AQAKRLKA
Length:318
Mass (Da):34,900
Last modified:July 1, 1997 - v1
Checksum:i0E9BE42EB7FFC2B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87980 Genomic DNA. Translation: AAC45402.1.

Genome annotation databases

KEGGiag:AAC45402.

Similar proteinsi

Entry informationi

Entry nameiMADC_MALRU
AccessioniPrimary (citable) accession number: O06926
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: July 1, 1997
Last modified: August 30, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program