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O06914

- FRDB_HELPY

UniProt

O06914 - FRDB_HELPY

Protein

Fumarate reductase iron-sulfur subunit

Gene

frdB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi65 – 651Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi68 – 681Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi154 – 1541Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi157 – 1571Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi160 – 1601Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi164 – 1641Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi211 – 2111Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi217 – 2171Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi221 – 2211Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0191-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fumarate reductase iron-sulfur subunit (EC:1.3.5.1)
    Gene namesi
    Name:frdB
    Ordered Locus Names:HP_0191
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Fumarate reductase iron-sulfur subunitPRO_0000158703Add
    BLAST

    Proteomic databases

    PRIDEiO06914.

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556.By similarity

    Protein-protein interaction databases

    IntActiO06914. 13 interactions.
    STRINGi85962.HP0191.

    Structurei

    3D structure databases

    ProteinModelPortaliO06914.
    SMRiO06914. Positions 6-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 98822Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini145 – 174304Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0479.
    KOiK00245.
    OMAiFMIDPHD.
    OrthoDBiEOG6CS02W.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    PF13183. Fer4_8. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O06914-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDNERTIVV RVLKFDPQSA VSKPHFKEYQ LKETPSMTLF IALNLIREHQ    50
    DPDLSFDFVC RAGICGSCAM MVNGRPRLAC KTLTSSFESG VITLMPMPSF 100
    TLIKDLSVNT GDWFLDMTKR VESWAHSKEE VDITRPEKRV EPDEAQEVFE 150
    LDRCIECGCC IASCGTKLMR PNFIGAAGMN RAMRFMIDSH DERNDDDFYE 200
    LVGDDDGVFG CMSLIACHDT CPKELPLQSS IATLRNRMLK VGKSR 245
    Length:245
    Mass (Da):27,652
    Last modified:November 1, 1997 - v2
    Checksum:iD54447471FB4C499
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti140 – 1401V → I in AAC46065. (PubMed:9434188)Curated
    Sequence conflicti194 – 1941N → S in AAC46065. (PubMed:9434188)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78101 Genomic DNA. Translation: AAC46065.1.
    AE000511 Genomic DNA. Translation: AAD07258.1.
    PIRiG64543.
    RefSeqiNP_206990.1. NC_000915.1.
    YP_006934114.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07258; AAD07258; HP_0191.
    GeneIDi13869370.
    899155.
    KEGGiheo:C694_00950.
    hpy:HP0191.
    PATRICi20591603. VBIHelPyl33062_0201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78101 Genomic DNA. Translation: AAC46065.1 .
    AE000511 Genomic DNA. Translation: AAD07258.1 .
    PIRi G64543.
    RefSeqi NP_206990.1. NC_000915.1.
    YP_006934114.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali O06914.
    SMRi O06914. Positions 6-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O06914. 13 interactions.
    STRINGi 85962.HP0191.

    Proteomic databases

    PRIDEi O06914.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07258 ; AAD07258 ; HP_0191 .
    GeneIDi 13869370.
    899155.
    KEGGi heo:C694_00950.
    hpy:HP0191.
    PATRICi 20591603. VBIHelPyl33062_0201.

    Phylogenomic databases

    eggNOGi COG0479.
    KOi K00245.
    OMAi FMIDPHD.
    OrthoDBi EOG6CS02W.

    Enzyme and pathway databases

    BioCyci HPY:HP0191-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    PF13183. Fer4_8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional characterization of Helicobacter pylori fumarate reductase operon comprising three structural genes coding for subunits C, A and B."
      Ge Z., Jiang Q., Kalisiak M.S., Taylor D.E.
      Gene 204:227-234(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43629 / JCM 7656 / NCTC 11639 / UA802.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiFRDB_HELPY
    AccessioniPrimary (citable) accession number: O06914
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3