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O06914

- FRDB_HELPY

UniProt

O06914 - FRDB_HELPY

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Protein
Fumarate reductase iron-sulfur subunit
Gene
frdB, HP_0191
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 1 3Fe-4S cluster By similarity.
Binds 1 4Fe-4S cluster By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi65 – 651Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi68 – 681Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi154 – 1541Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi157 – 1571Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi160 – 1601Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi164 – 1641Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi211 – 2111Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi217 – 2171Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi221 – 2211Iron-sulfur 2 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0191-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:frdB
Ordered Locus Names:HP_0191
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Fumarate reductase iron-sulfur subunit
PRO_0000158703Add
BLAST

Proteomic databases

PRIDEiO06914.

Interactioni

Subunit structurei

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556 By similarity.

Protein-protein interaction databases

IntActiO06914. 13 interactions.
STRINGi85962.HP0191.

Structurei

3D structure databases

ProteinModelPortaliO06914.
SMRiO06914. Positions 6-241.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 98822Fe-2S ferredoxin-type
Add
BLAST
Domaini145 – 174304Fe-4S ferredoxin-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0479.
KOiK00245.
OMAiFMIDPHD.
OrthoDBiEOG6CS02W.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O06914-1 [UniParc]FASTAAdd to Basket

« Hide

MSDNERTIVV RVLKFDPQSA VSKPHFKEYQ LKETPSMTLF IALNLIREHQ    50
DPDLSFDFVC RAGICGSCAM MVNGRPRLAC KTLTSSFESG VITLMPMPSF 100
TLIKDLSVNT GDWFLDMTKR VESWAHSKEE VDITRPEKRV EPDEAQEVFE 150
LDRCIECGCC IASCGTKLMR PNFIGAAGMN RAMRFMIDSH DERNDDDFYE 200
LVGDDDGVFG CMSLIACHDT CPKELPLQSS IATLRNRMLK VGKSR 245
Length:245
Mass (Da):27,652
Last modified:November 1, 1997 - v2
Checksum:iD54447471FB4C499
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1401V → I in AAC46065. 1 Publication
Sequence conflicti194 – 1941N → S in AAC46065. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U78101 Genomic DNA. Translation: AAC46065.1.
AE000511 Genomic DNA. Translation: AAD07258.1.
PIRiG64543.
RefSeqiNP_206990.1. NC_000915.1.
YP_006934114.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07258; AAD07258; HP_0191.
GeneIDi13869370.
899155.
KEGGiheo:C694_00950.
hpy:HP0191.
PATRICi20591603. VBIHelPyl33062_0201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U78101 Genomic DNA. Translation: AAC46065.1 .
AE000511 Genomic DNA. Translation: AAD07258.1 .
PIRi G64543.
RefSeqi NP_206990.1. NC_000915.1.
YP_006934114.1. NC_018939.1.

3D structure databases

ProteinModelPortali O06914.
SMRi O06914. Positions 6-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O06914. 13 interactions.
STRINGi 85962.HP0191.

Proteomic databases

PRIDEi O06914.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07258 ; AAD07258 ; HP_0191 .
GeneIDi 13869370.
899155.
KEGGi heo:C694_00950.
hpy:HP0191.
PATRICi 20591603. VBIHelPyl33062_0201.

Phylogenomic databases

eggNOGi COG0479.
KOi K00245.
OMAi FMIDPHD.
OrthoDBi EOG6CS02W.

Enzyme and pathway databases

BioCyci HPY:HP0191-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of Helicobacter pylori fumarate reductase operon comprising three structural genes coding for subunits C, A and B."
    Ge Z., Jiang Q., Kalisiak M.S., Taylor D.E.
    Gene 204:227-234(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43629 / JCM 7656 / NCTC 11639 / UA802.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiFRDB_HELPY
AccessioniPrimary (citable) accession number: O06914
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi