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O06914 (FRDB_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fumarate reductase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:frdB
Ordered Locus Names:HP_0191
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Subunit structure

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556 By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Fumarate reductase iron-sulfur subunit
PRO_0000158703

Regions

Domain17 – 98822Fe-2S ferredoxin-type
Domain145 – 174304Fe-4S ferredoxin-type

Sites

Metal binding601Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding651Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding681Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding801Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1541Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1571Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1601Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1641Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2111Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2171Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2211Iron-sulfur 2 (4Fe-4S) By similarity

Experimental info

Sequence conflict1401V → I in AAC46065. Ref.1
Sequence conflict1941N → S in AAC46065. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O06914 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: D54447471FB4C499

FASTA24527,652
        10         20         30         40         50         60 
MSDNERTIVV RVLKFDPQSA VSKPHFKEYQ LKETPSMTLF IALNLIREHQ DPDLSFDFVC 

        70         80         90        100        110        120 
RAGICGSCAM MVNGRPRLAC KTLTSSFESG VITLMPMPSF TLIKDLSVNT GDWFLDMTKR 

       130        140        150        160        170        180 
VESWAHSKEE VDITRPEKRV EPDEAQEVFE LDRCIECGCC IASCGTKLMR PNFIGAAGMN 

       190        200        210        220        230        240 
RAMRFMIDSH DERNDDDFYE LVGDDDGVFG CMSLIACHDT CPKELPLQSS IATLRNRMLK 


VGKSR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U78101 Genomic DNA. Translation: AAC46065.1.
AE000511 Genomic DNA. Translation: AAD07258.1.
PIRG64543.
RefSeqNP_206990.1. NC_000915.1.
YP_006934114.1. NC_018939.1.

3D structure databases

ProteinModelPortalO06914.
SMRO06914. Positions 6-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO06914. 13 interactions.
STRING85962.HP0191.

Proteomic databases

PRIDEO06914.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07258; AAD07258; HP_0191.
GeneID899155.
KEGGheo:C694_00950.
hpy:HP0191.
PATRIC20591603. VBIHelPyl33062_0201.

Phylogenomic databases

eggNOGCOG0479.
KOK00245.
OMAFMIDPHD.
OrthoDBEOG6CS02W.

Enzyme and pathway databases

BioCycHPY:HP0191-MONOMER.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRDB_HELPY
AccessionPrimary (citable) accession number: O06914
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names