ID   FRDA_HELPY              Reviewed;         714 AA.
AC   O06913;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   16-JUN-2009, entry version 72.
DE   RecName: Full=Fumarate reductase flavoprotein subunit;
DE            EC=1.3.99.1;
GN   Name=frdA; OrderedLocusNames=HP_0192;
OS   Helicobacter pylori (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=210;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43629 / JCM 7656 / NCTC 11639 / UA802;
RX   MEDLINE=98094277; PubMed=9434188; DOI=10.1016/S0378-1119(97)00550-7;
RA   Ge Z., Jiang Q., Kalisiak M.S., Taylor D.E.;
RT   "Cloning and functional characterization of Helicobacter pylori
RT   fumarate reductase operon comprising three structural genes coding for
RT   subunits C, A and B.";
RL   Gene 204:227-234(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   MEDLINE=97394467; PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R.,
RA   Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F.,
RA   Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G.,
RA   Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D.,
RA   Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D.,
RA   Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C.,
RA   Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D.,
RA   Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced
CC       acceptor.
CC   -!- COFACTOR: Binds 1 FAD covalently per subunit (By similarity).
CC   -!- SUBUNIT: Part of an enzyme complex containing three subunits: a
CC       flavoprotein, an iron-sulfur, and cytochrome b-556 (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family.
CC       FRD/SDH subfamily.
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DR   EMBL; U78101; AAC46064.1; -; Genomic_DNA.
DR   EMBL; AE000511; AAD07259.1; -; Genomic_DNA.
DR   PIR; H64543; H64543.
DR   RefSeq; NP_206991.1; -.
DR   HSSP; P17412; 1QLA.
DR   SMR; O06913; 1-682.
DR   DIP; DIP:3345N; -.
DR   GeneID; 900116; -.
DR   GenomeReviews; AE000511_GR; HP_0192.
DR   KEGG; hpy:HP0192; -.
DR   NMPDR; fig|85962.1.peg.189; -.
DR   TIGR; HP_0192; -.
DR   HOGENOM; O06913; -.
DR   OMA; O06913; DATGHTM.
DR   BRENDA; 1.3.99.1; 1131.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0000104; F:succinate dehydrogenase activity; IEA:EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003953; FAD_bind2_N.
DR   InterPro; IPR003952; FRD_SDH_FAD_BS.
DR   InterPro; IPR004112; Fum_Rdtase/Succ_DH_flav_C.
DR   InterPro; IPR014006; Succ_Dhase_frdA_Gneg.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   Pfam; PF02910; Succ_DH_flav_C; 1.
DR   TIGRFAMs; TIGR01812; sdhA_frdA_Gneg; 1.
DR   PROSITE; PS00504; FRD_SDH_FAD_BINDING; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Electron transport; FAD; Flavoprotein;
KW   Oxidoreductase; Transport.
FT   CHAIN         1    714       Fumarate reductase flavoprotein subunit.
FT                                /FTId=PRO_0000158662.
FT   NP_BIND       9     23       FAD (Potential).
FT   ACT_SITE    257    257       By similarity.
FT   ACT_SITE    273    273       By similarity.
FT   MOD_RES      43     43       Tele-8alpha-FAD histidine (By
FT                                similarity).
FT   CONFLICT    112    112       K -> R (in Ref. 1; AAC46064).
FT   CONFLICT    170    175       HHKVDI -> NTTKWIL (in Ref. 1; AAC46064).
FT   CONFLICT    361    361       K -> E (in Ref. 1; AAC46064).
FT   CONFLICT    371    373       VPA -> MPT (in Ref. 1; AAC46064).
FT   CONFLICT    513    513       R -> K (in Ref. 1; AAC46064).
FT   CONFLICT    615    624       MEISPDFRGY -> WKSALILGAM (in Ref. 1;
FT                                AAC46064).
FT   CONFLICT    658    658       I -> V (in Ref. 1; AAC46064).
FT   CONFLICT    699    699       E -> D (in Ref. 1; AAC46064).
FT   CONFLICT    703    703       Q -> K (in Ref. 1; AAC46064).
SQ   SEQUENCE   714 AA;  80121 MW;  D4639213CB19B3A9 CRC64;
     MKITYCDALI IGGGLAGLRA SIACKQKGLN TIVLSLVPVR RSHSAAAQGG MQASLANAKK
     SEGDNEDLHF LDTVKGSDWG CDQQVARMFV TTAPKAIREL ASWGVPWTRI KKGDRPAVVN
     GEHVTITERD DRHGYILSRD FGGTKKWRTC FTADATGHTM LYAVANEALH HKVDIQDRKD
     MLAFIHHDNK CYGAVVRDLI TGEISAYVSK GTLLATGGYG RVYKHTTNAV ICDGAGAASA
     LETGVAKLGN MEAVQFHPTA LVPSGILMTE GCRGDGGVLR DKFGRRFMPA YEPEKKELAS
     RDVVSRRILE HIQKGYGAKS PYGDHVWLDI AILGRNHVEK NLRDVRDIAM TFAGIDPADS
     KEQTKDNMQG VPANEPEYGQ AMAKQKGWIP IKPMQHYSMG GVRTNPKGET HLKGLFCAGE
     AACWDLHGFN RLGGNSVSEA VVAGMIIGDY FASHCLEAQI EINTQKVEAF IKESQDYMHF
     LLHNEGKEDV YEIRERMKEV MDEKVGVFRE GKRLEEALKE LQELYARSKN ICVKNKVLHN
     NPELEDAYRT KKMLKLALCI TQGALLRTES RGAHTRIDYP KRDDEKWLNR TLASWPSAEQ
     DMPTIEYEEL DVMKMEISPD FRGYGKKGNF IPHPKKEERD AEILKTILEL EKLGKDRIEV
     QHALMPFELQ EKYKARNMRL EDEEVRARGE HLYSFNVHEL LDQHNANLKG EHHE
//