Fumarate reductase flavoprotein subunit - Helicobacter pylori

Contribute

Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot O06913 (FRDA_HELPY)

Last modified June 16, 2009. Version 72. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Fumarate reductase flavoprotein subunit
EC=1.3.99.1

Gene names

Name:	frdA
Ordered Locus Names:	HP_0192

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	714 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate + acceptor = fumarate + reduced acceptor.
Cofactor	Binds 1 FAD covalently per subunit By similarity.
Subunit structure	Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556 By similarity.
Sequence similarities	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro succinate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

714

Fumarate reductase flavoprotein subunit

PRO_0000158662

Regions

Nucleotide binding

15

FAD Potential

Sites

Active site

1

By similarity

Active site

1

By similarity

Amino acid modifications

Modified residue

1

Tele-8alpha-FAD histidine By similarity

Experimental info

Sequence conflict

1

K → R in AAC46064. Ref.1

Sequence conflict

6

HHKVDI → NTTKWIL in AAC46064. Ref.1

Sequence conflict

1

K → E in AAC46064. Ref.1

Sequence conflict

3

VPA → MPT in AAC46064. Ref.1

Sequence conflict

1

R → K in AAC46064. Ref.1

Sequence conflict

10

MEISPDFRGY → WKSALILGAM in AAC46064. Ref.1

Sequence conflict

1

I → V in AAC46064. Ref.1

Sequence conflict

1

E → D in AAC46064. Ref.1

Sequence conflict

1

Q → K in AAC46064. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O06913-1 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: D4639213CB19B3A9
Show »

714

80,121

        10         20         30         40         50         60 
MKITYCDALI IGGGLAGLRA SIACKQKGLN TIVLSLVPVR RSHSAAAQGG MQASLANAKK 

        70         80         90        100        110        120 
SEGDNEDLHF LDTVKGSDWG CDQQVARMFV TTAPKAIREL ASWGVPWTRI KKGDRPAVVN 

       130        140        150        160        170        180 
GEHVTITERD DRHGYILSRD FGGTKKWRTC FTADATGHTM LYAVANEALH HKVDIQDRKD 

       190        200        210        220        230        240 
MLAFIHHDNK CYGAVVRDLI TGEISAYVSK GTLLATGGYG RVYKHTTNAV ICDGAGAASA 

       250        260        270        280        290        300 
LETGVAKLGN MEAVQFHPTA LVPSGILMTE GCRGDGGVLR DKFGRRFMPA YEPEKKELAS 

       310        320        330        340        350        360 
RDVVSRRILE HIQKGYGAKS PYGDHVWLDI AILGRNHVEK NLRDVRDIAM TFAGIDPADS 

       370        380        390        400        410        420 
KEQTKDNMQG VPANEPEYGQ AMAKQKGWIP IKPMQHYSMG GVRTNPKGET HLKGLFCAGE 

       430        440        450        460        470        480 
AACWDLHGFN RLGGNSVSEA VVAGMIIGDY FASHCLEAQI EINTQKVEAF IKESQDYMHF 

       490        500        510        520        530        540 
LLHNEGKEDV YEIRERMKEV MDEKVGVFRE GKRLEEALKE LQELYARSKN ICVKNKVLHN 

       550        560        570        580        590        600 
NPELEDAYRT KKMLKLALCI TQGALLRTES RGAHTRIDYP KRDDEKWLNR TLASWPSAEQ 

       610        620        630        640        650        660 
DMPTIEYEEL DVMKMEISPD FRGYGKKGNF IPHPKKEERD AEILKTILEL EKLGKDRIEV 

       670        680        690        700        710 
QHALMPFELQ EKYKARNMRL EDEEVRARGE HLYSFNVHEL LDQHNANLKG EHHE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional characterization of Helicobacter pylori fumarate reductase operon comprising three structural genes coding for subunits C, A and B." Ge Z., Jiang Q., Kalisiak M.S., Taylor D.E. Gene 204:227-234(1997) [PubMed: 9434188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43629 / JCM 7656 / NCTC 11639 / UA802.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
	U78101 Genomic DNA. Translation: AAC46064.1. AE000511 Genomic DNA. Translation: AAD07259.1.
PIR	H64543.
RefSeq	NP_206991.1.
3D structure databases
HSSP	HSSP built from PDB template 1QLA based on UniProtKB P17412.
SMR	O06913. Positions 1-682.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3345N.
Genome annotation databases
GeneID	900116.
GenomeReviews	Gene locus HP_0192 in contig AE000511_GR.
KEGG	hpy:HP0192.
NMPDR	fig\|85962.1.peg.189.
TIGR	HP_0192.
Phylogenomic databases
HOGENOM	O06913.
OMA	O06913. DATGHTM.
Enzyme and pathway databases
BRENDA	1.3.99.1. 1131.
Family and domain databases
InterPro	IPR003953. FAD_bind2_N. IPR003952. FRD_SDH_FAD_BS. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view]
Pfam	PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITE	PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRDA_HELPY

Accession

Primary (citable) accession number: O06913

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents