O06912 (FRDC_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fumarate reductase cytochrome b subunit

Gene names

Name:	frdC
Ordered Locus Names:	HP_0193

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Di-heme cytochrome of the fumarate reductase complex By similarity.
Subunit structure	Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on the CH-CH group of donors Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Fumarate reductase cytochrome b subunit		PRO_0000158683
Regions
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	126 – 146	21	Helical; Potential
	Transmembrane	168 – 188	21	Helical; Potential
	Transmembrane	208 – 228	21	Helical; Potential
Sites
	Metal binding	44	1	Iron (heme axial ligand) Potential
	Metal binding	93	1	Iron (heme axial ligand) Potential
	Metal binding	143	1	Iron (heme axial ligand) Potential
	Metal binding	182	1	Iron (heme axial ligand) Potential
Experimental info
	Sequence conflict	86	1	I → V in AAC46063. Ref.1
	Sequence conflict	90	1	L → V in AAC46063. Ref.1
	Sequence conflict	200	1	V → A in AAC46063. Ref.1
	Sequence conflict	236	1	E → D in AAC46063. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O06912 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: E74716D64957AD50	FASTA	255	28,886
	10 20 30 40 50 60 MQQEEIIEGY YGASKGLKKS GIYAKLDFLQ SATGLILALF MIAHMFLVSS ILISDEAMYK 70 80 90 100 110 120 VAKFFEGSLF LKAGEPAIVS VVAAGIILIL VAHAFLALRK FPINYRQYKV FKTHKHLMKH 130 140 150 160 170 180 GDTSLWFIQA LTGFAMFFLA SIHLFVMLTE PESIGPHGSS YRFVTQNFWL LYIFLLFAVE 190 200 210 220 230 240 LHGSIGLYRL AIKWGWFKNV SIQGLRKVKW AMSVFFIVLG LCTYGAYIKK GLENKENGIK 250 TMQEAIEADG KFHKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional characterization of Helicobacter pylori fumarate reductase operon comprising three structural genes coding for subunits C, A and B." Ge Z., Jiang Q., Kalisiak M.S., Taylor D.E. Gene 204:227-234(1997) [PubMed: 9434188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43629 / JCM 7656 / NCTC 11639 / UA802.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U78101 Genomic DNA. Translation: AAC46063.1. AE000511 Genomic DNA. Translation: AAD07260.1.
PIR	A64544.
RefSeq	NP_206992.1. NC_000915.1.
3D structure databases
ProteinModelPortal	O06912.
SMR	O06912. Positions 1-240.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	898966.
GenomeReviews	Gene locus HP_0193 in contig AE000511_GR.
KEGG	hpy:HP0193.
NMPDR	fig|85962.1.peg.190.
PATRIC	20591607. VBIHelPyl33062_0203.
TIGR	HP_0193.
Phylogenomic databases
HOGENOM	HBG463746.
OMA	TGFAMFF.
ProtClustDB	PRK13553.
Family and domain databases
InterPro	IPR004224. Fum_red_TM. IPR000701. Succ_DH_Fumarate_Rdtase_TM-su. [Graphical view]
KO	K00246.
Pfam	PF01127. Sdh_cyt. 1 hit. [Graphical view]
PIRSF	PIRSF000177. Fumar_rd_cyt_b. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FRDC_HELPY

Accession

Primary (citable) accession number: O06912

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program