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Protein

Subtilisin inhibitor

Gene

vsi

Organism
Streptomyces violaceus (Streptomyces venezuelae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Strong inhibitor of bacterial serine proteases such as subtilisin.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei104 – 1052Reactive bondBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI16.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Subtilisin inhibitor
Gene namesi
Name:vsi
Synonyms:ssi
OrganismiStreptomyces violaceus (Streptomyces venezuelae)
Taxonomic identifieri1936 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Add
BLAST
Chaini29 – 146118Subtilisin inhibitorPRO_0000033278Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 80By similarity
Disulfide bondi102 ↔ 132By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO06871.
SMRiO06871. Positions 37-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.350.10. 1 hit.
HAMAPiMF_00778. SSI. 1 hit.
InterProiIPR000691. Prot_inh_I16_SSI.
IPR020054. Prot_inh_SSI_I16_CS.
IPR023549. Subtilisin_inhibitor.
[Graphical view]
PfamiPF00720. SSI. 1 hit.
[Graphical view]
PRINTSiPR00294. SSBTLNINHBTR.
ProDomiPD004028. Prot_inh_SSI. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55399. SSF55399. 1 hit.
PROSITEiPS00999. SSI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O06871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTLKAVGA AAAAATCVLA ATAGTAQAEA PKAESLYAPS ALVLTVGQGE
60 70 80 90 100
NAESAAVERA VTLTCAPRPG GTHPSAAAAC AELAKVNGQF ARLVGASSDA
110 120 130 140
ICTKEWRPVT VSVVGAWNGK HVNWTSTFAN QCTMKAGLGE GAALTF
Length:146
Mass (Da):14,629
Last modified:July 1, 1997 - v1
Checksum:iA68DD11812A027BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98019 Genomic DNA. Translation: CAA66652.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98019 Genomic DNA. Translation: CAA66652.1.

3D structure databases

ProteinModelPortaliO06871.
SMRiO06871. Positions 37-140.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI16.016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.350.10. 1 hit.
HAMAPiMF_00778. SSI. 1 hit.
InterProiIPR000691. Prot_inh_I16_SSI.
IPR020054. Prot_inh_SSI_I16_CS.
IPR023549. Subtilisin_inhibitor.
[Graphical view]
PfamiPF00720. SSI. 1 hit.
[Graphical view]
PRINTSiPR00294. SSBTLNINHBTR.
ProDomiPD004028. Prot_inh_SSI. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55399. SSF55399. 1 hit.
PROSITEiPS00999. SSI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSI_STRVL
AccessioniPrimary (citable) accession number: O06871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: July 1, 1997
Last modified: October 14, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.