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Protein

Putative isomerase YitF

Gene

yitF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+CuratedNote: Divalent metal cations. Mg2+.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581By similarity
Metal bindingi214 – 2141Magnesium
Metal bindingi240 – 2401Magnesium
Active sitei290 – 2901By similarity
Metal bindingi290 – 2901Magnesium

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU10970-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative isomerase YitF (EC:5.-.-.-)
Gene namesi
Name:yitF
Ordered Locus Names:BSU10970
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Putative isomerase YitFPRO_0000360691Add
BLAST

Proteomic databases

PaxDbiO06741.

Interactioni

Subunit structurei

Homooctamer.1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100006056.

Structurei

Secondary structure

1
371
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 2120Combined sources
Beta strandi24 – 3815Combined sources
Beta strandi43 – 486Combined sources
Helixi52 – 6110Combined sources
Helixi63 – 675Combined sources
Helixi75 – 8511Combined sources
Helixi87 – 10418Combined sources
Helixi109 – 1124Combined sources
Beta strandi119 – 1268Combined sources
Helixi136 – 14813Combined sources
Turni149 – 1513Combined sources
Beta strandi154 – 1585Combined sources
Beta strandi160 – 1623Combined sources
Helixi164 – 17815Combined sources
Beta strandi182 – 1876Combined sources
Helixi194 – 1985Combined sources
Helixi201 – 2044Combined sources
Beta strandi210 – 2145Combined sources
Helixi222 – 2298Combined sources
Beta strandi236 – 2383Combined sources
Helixi245 – 2539Combined sources
Beta strandi258 – 2603Combined sources
Turni264 – 2685Combined sources
Helixi269 – 28315Combined sources
Helixi296 – 30611Combined sources
Beta strandi311 – 3133Combined sources
Beta strandi322 – 3254Combined sources
Helixi330 – 3345Combined sources
Beta strandi343 – 3453Combined sources
Beta strandi349 – 3513Combined sources
Helixi358 – 3636Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GDQX-ray1.80A/B2-371[»]
2GGEX-ray1.89A/B/C/D/E/F/G/H2-371[»]
ProteinModelPortaliO06741.
SMRiO06741. Positions 1-371.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO06741.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DIA. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000097984.
InParanoidiO06741.
OMAiPQWISRS.
OrthoDBiEOG6S52NQ.
PhylomeDBiO06741.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.

Sequencei

Sequence statusi: Complete.

O06741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVRIETFP LFHRLEKPYG DANGFKRYRT CYLIRIITES GIDGWGECVD
60 70 80 90 100
WLPALHVGFT KRIIPFLLGK QAGSRLSLVR TIQKWHQRAA SAVSMALTEI
110 120 130 140 150
AAKAADCSVC ELWGGRYREE IPVYASFQSY SDSPQWISRS VSNVEAQLKK
160 170 180 190 200
GFEQIKVKIG GTSFKEDVRH INALQHTAGS SITMILDANQ SYDAAAAFKW
210 220 230 240 250
ERYFSEWTNI GWLEEPLPFD QPQDYAMLRS RLSVPVAGGE NMKGPAQYVP
260 270 280 290 300
LLSQRCLDII QPDVMHVNGI DEFRDCLQLA RYFGVRASAH AYDGSLSRLY
310 320 330 340 350
ALFAQACLPP WSKMKNDHIE PIEWDVMENP FTDLVSLQPS KGMVHIPKGK
360 370
GIGTEINMEI VNRYKWDGSA Y
Length:371
Mass (Da):42,052
Last modified:July 1, 1997 - v1
Checksum:iC41FD69E471FE87E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09476 Genomic DNA. Translation: CAA70661.1.
AL009126 Genomic DNA. Translation: CAB12937.1.
PIRiG69839.
RefSeqiNP_388978.1. NC_000964.3.
WP_003245056.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB12937; CAB12937; BSU10970.
GeneIDi939345.
KEGGibsu:BSU10970.
PATRICi18973900. VBIBacSub10457_1144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09476 Genomic DNA. Translation: CAA70661.1.
AL009126 Genomic DNA. Translation: CAB12937.1.
PIRiG69839.
RefSeqiNP_388978.1. NC_000964.3.
WP_003245056.1. NZ_JNCM01000035.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GDQX-ray1.80A/B2-371[»]
2GGEX-ray1.89A/B/C/D/E/F/G/H2-371[»]
ProteinModelPortaliO06741.
SMRiO06741. Positions 1-371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100006056.

Proteomic databases

PaxDbiO06741.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12937; CAB12937; BSU10970.
GeneIDi939345.
KEGGibsu:BSU10970.
PATRICi18973900. VBIBacSub10457_1144.

Phylogenomic databases

eggNOGiENOG4105DIA. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000097984.
InParanoidiO06741.
OMAiPQWISRS.
OrthoDBiEOG6S52NQ.
PhylomeDBiO06741.

Enzyme and pathway databases

BioCyciBSUB:BSU10970-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO06741.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A Bacillus subtilis chromosome segment at the 100 degrees to 102 degrees position encoding 11 membrane proteins."
    Roche B., Autret S., Levine A., Vannier F., Medina N., Seror S.J.
    Microbiology 143:3309-3312(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Crystal structure of mandelate racemase/muconate lactonizing enzyme from Bacillus subtilis at 1.8 A resolution."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (APR-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH MAGNESIUM IONS, SUBUNIT.

Entry informationi

Entry nameiYITF_BACSU
AccessioniPrimary (citable) accession number: O06741
Secondary accession number(s): Q796Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 1, 1997
Last modified: February 17, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.