O06737 (CYSH2_BACSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 91.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable phosphoadenosine phosphosulfate reductase EC=1.8.4.8 Alternative name(s): 3'-phosphoadenylylsulfate reductase PAPS reductase, thioredoxin dependent PAPS sulfotransferase PAdoPS reductase | ||||
| Gene names |
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| Organism | Bacillus subtilis | ||||
| Taxonomic identifier | 1423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 236 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Reduction of activated sulfate into sulfite. HAMAP MF_00063 |
| Catalytic activity | Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin. HAMAP MF_00063 |
| Pathway | Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3. HAMAP MF_00063 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00063. |
| Sequence similarities | Belongs to the PAPS reductase family. CysH subfamily. |
| Sequence caution | The sequence CAA70657.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cysteine biosynthetic process Inferred from electronic annotation. Source: InterPro sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | phosphoadenylyl-sulfate reductase (thioredoxin) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 236 | 236 | Probable phosphoadenosine phosphosulfate reductase HAMAP MF_00063 | PRO_0000100627 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A Bacillus subtilis chromosome segment at the 100 degrees to 102 degrees position encoding 11 membrane proteins." Roche B., Autret S., Levine A., Vannier F., Medina N., Seror S.J. Microbiology 143:3309-3312(1997) [PubMed: 9353932] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.  Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Y09476 Genomic DNA. Translation: CAA70657.1. Different initiation. AL009126 Genomic DNA. Translation: CAB12933.2. |
| PIR | C69839. |
| RefSeq | NP_388974.2. NC_000964.3. |
3D structure databases | |
| ProteinModelPortal | O06737. |
| SMR | O06737. Positions 12-226. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000001541; EBBACP00000001541; EBBACG00000001539. |
| GeneID | 939787. |
| GenomeReviews | Gene locus BSU10930 in contig AL009126_GR. |
| KEGG | bsu:BSU10930. |
| NMPDR | fig|224308.1.peg.1093. |
| PATRIC | 18973892. VBIBacSub10457_1140. |
Organism-specific databases | |
| GenoList | BSU10930. |
Phylogenomic databases | |
| GeneTree | EBGT00050000002870. |
| HOGENOM | HBG758022. |
| OMA | LIKICPL. |
| PhylomeDB | O06737. |
| ProtClustDB | CLSK737559. |
Enzyme and pathway databases | |
| BioCyc | BSUB:BSU10930-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00063. CysH. [Tree] |
| InterPro | IPR011798. APS_reductase. IPR004511. PAPS/APS_Rdtase. IPR002500. PAPS_reduct. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| KO | K00390. |
| Pfam | PF01507. PAPS_reduct. 1 hit. [Graphical view] |
| PIRSF | PIRSF000857. PAPS_reductase. 1 hit. |
| TIGRFAMs | TIGR02055. APS_reductase. 1 hit. TIGR00434. CysH. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | CYSH2_BACSU | ||||||||
| Accession | Primary (citable) accession number: O06737 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |