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O06553

- Y1155_MYCTU

UniProt

O06553 - Y1155_MYCTU

Protein

Putative pyridoxine/pyridoxamine 5'-phosphate oxidase

Gene

Rv1155

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).Curated

    Catalytic activityi

    Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.
    Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371FMN1 Publication
    Binding sitei50 – 501FMN; via carbonyl oxygen1 Publication
    Binding sitei79 – 791Pyridoxal phosphate1 Publication

    GO - Molecular functioni

    1. FMN binding Source: MTBBASE
    2. protein homodimerization activity Source: MTBBASE
    3. pyridoxal phosphate binding Source: MTBBASE
    4. pyridoxamine-phosphate oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. vitamin B6 metabolic process Source: MTBBASE

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    BioCyciMTBRV:RV1155-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative pyridoxine/pyridoxamine 5'-phosphate oxidase (EC:1.4.3.5)
    Alternative name(s):
    PNP/PMP oxidase
    Short name:
    PNPOx
    Pyridoxal 5'-phosphate synthase
    Gene namesi
    Ordered Locus Names:Rv1155
    OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
    Taxonomic identifieri83332 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001584: Chromosome

    Organism-specific databases

    TubercuListiRv1155.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Putative pyridoxine/pyridoxamine 5'-phosphate oxidasePRO_0000399901Add
    BLAST

    Proteomic databases

    PRIDEiO06553.

    Interactioni

    Subunit structurei

    Homodimer.2 Publications

    Protein-protein interaction databases

    STRINGi83332.Rv1155.

    Structurei

    Secondary structure

    1
    147
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1510
    Beta strandi18 – 258
    Beta strandi31 – 377
    Beta strandi39 – 413
    Turni42 – 454
    Beta strandi46 – 527
    Helixi56 – 638
    Beta strandi66 – 727
    Beta strandi74 – 774
    Beta strandi79 – 857
    Helixi98 – 11013
    Helixi117 – 12610
    Beta strandi129 – 1357
    Beta strandi138 – 1425

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1W9AX-ray1.80A/B1-147[»]
    1XXOX-ray1.80A/B1-147[»]
    1Y30X-ray2.20A/B1-147[»]
    2AQ6X-ray1.70A/B1-147[»]
    ProteinModelPortaliO06553.
    SMRiO06553. Positions 5-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO06553.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni32 – 354FMN binding
    Regioni34 – 352Pyridoxal phosphate binding
    Regioni55 – 573FMN binding
    Regioni55 – 573Pyridoxal phosphate binding

    Phylogenomic databases

    eggNOGiNOG07001.
    HOGENOMiHOG000022434.
    KOiK07005.
    OMAiGRAKVAN.
    OrthoDBiEOG6VB6XZ.
    PhylomeDBiO06553.

    Family and domain databases

    Gene3Di2.30.110.10. 1 hit.
    InterProiIPR019920. F420-binding_dom_put.
    IPR011576. Pyridox_Oxase_FMN-bd.
    IPR012349. Split_barrel_FMN-bd.
    [Graphical view]
    PfamiPF01243. Pyridox_oxidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF50475. SSF50475. 1 hit.
    TIGRFAMsiTIGR03618. Rv1155_F420. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O06553-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARQVFDDKL LAVISGNSIG VLATIKHDGR PQLSNVQYHF DPRKLLIQVS    50
    IAEPRAKTRN LRRDPRASIL VDADDGWSYA VAEGTAQLTP PAAAPDDDTV 100
    EALIALYRNI AGEHSDWDDY RQAMVTDRRV LLTLPISHVY GLPPGMR 147
    Length:147
    Mass (Da):16,301
    Last modified:July 1, 1997 - v1
    Checksum:iDAF63639A04D6A0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP43910.1.
    PIRiD70555.
    RefSeqiNP_215671.1. NC_000962.3.
    YP_006514527.1. NC_018143.2.

    Genome annotation databases

    EnsemblBacteriaiCCP43910; CCP43910; Rv1155.
    GeneIDi13319731.
    885604.
    KEGGimtu:Rv1155.
    mtv:RVBD_1155.
    PATRICi18151117. VBIMycTub87468_1296.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL123456 Genomic DNA. Translation: CCP43910.1 .
    PIRi D70555.
    RefSeqi NP_215671.1. NC_000962.3.
    YP_006514527.1. NC_018143.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1W9A X-ray 1.80 A/B 1-147 [» ]
    1XXO X-ray 1.80 A/B 1-147 [» ]
    1Y30 X-ray 2.20 A/B 1-147 [» ]
    2AQ6 X-ray 1.70 A/B 1-147 [» ]
    ProteinModelPortali O06553.
    SMRi O06553. Positions 5-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 83332.Rv1155.

    Proteomic databases

    PRIDEi O06553.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCP43910 ; CCP43910 ; Rv1155 .
    GeneIDi 13319731.
    885604.
    KEGGi mtu:Rv1155.
    mtv:RVBD_1155.
    PATRICi 18151117. VBIMycTub87468_1296.

    Organism-specific databases

    TubercuListi Rv1155.

    Phylogenomic databases

    eggNOGi NOG07001.
    HOGENOMi HOG000022434.
    KOi K07005.
    OMAi GRAKVAN.
    OrthoDBi EOG6VB6XZ.
    PhylomeDBi O06553.

    Enzyme and pathway databases

    BioCyci MTBRV:RV1155-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O06553.

    Family and domain databases

    Gene3Di 2.30.110.10. 1 hit.
    InterProi IPR019920. F420-binding_dom_put.
    IPR011576. Pyridox_Oxase_FMN-bd.
    IPR012349. Split_barrel_FMN-bd.
    [Graphical view ]
    Pfami PF01243. Pyridox_oxidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50475. SSF50475. 1 hit.
    TIGRFAMsi TIGR03618. Rv1155_F420. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25618 / H37Rv.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ATCC 25618 / H37Rv.
    3. "Structures of Mycobacterium tuberculosispyridoxine 5'-phosphate oxidase and its complexes with flavin mononucleotide and pyridoxal 5'-phosphate."
      Biswal B.K., Cherney M.M., Wang M., Garen C., James M.N.
      Acta Crystallogr. D 61:1492-1499(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH FMN AND PYRIDOXAL PHOSPHATE, SUBUNIT.
    4. "Crystal structure of the conserved hypothetical protein Rv1155 from Mycobacterium tuberculosis."
      Canaan S., Sulzenbacher G., Roig-Zamboni V., Scappuccini-Calvo L., Frassinetti F., Maurin D., Cambillau C., Bourne Y.
      FEBS Lett. 579:215-221(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), SUBUNIT.

    Entry informationi

    Entry nameiY1155_MYCTU
    AccessioniPrimary (citable) accession number: O06553
    Secondary accession number(s): L0T7G6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2010
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
      Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3