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O06553

- Y1155_MYCTU

UniProt

O06553 - Y1155_MYCTU

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Protein

Putative pyridoxine/pyridoxamine 5'-phosphate oxidase

Gene
Rv1155
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) Reviewed prediction.

Catalytic activityi

Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.
Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371FMN
Binding sitei50 – 501FMN; via carbonyl oxygen
Binding sitei79 – 791Pyridoxal phosphate

GO - Molecular functioni

  1. FMN binding Source: MTBBASE
  2. protein homodimerization activity Source: MTBBASE
  3. pyridoxal phosphate binding Source: MTBBASE
  4. pyridoxamine-phosphate oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. vitamin B6 metabolic process Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciMTBRV:RV1155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyridoxine/pyridoxamine 5'-phosphate oxidase (EC:1.4.3.5)
Alternative name(s):
PNP/PMP oxidase
Short name:
PNPOx
Pyridoxal 5'-phosphate synthase
Gene namesi
Ordered Locus Names:Rv1155
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001584: Chromosome

Organism-specific databases

TubercuListiRv1155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Putative pyridoxine/pyridoxamine 5'-phosphate oxidasePRO_0000399901Add
BLAST

Proteomic databases

PRIDEiO06553.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

STRINGi83332.Rv1155.

Structurei

Secondary structure

1
147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1510
Beta strandi18 – 258
Beta strandi31 – 377
Beta strandi39 – 413
Turni42 – 454
Beta strandi46 – 527
Helixi56 – 638
Beta strandi66 – 727
Beta strandi74 – 774
Beta strandi79 – 857
Helixi98 – 11013
Helixi117 – 12610
Beta strandi129 – 1357
Beta strandi138 – 1425

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W9AX-ray1.80A/B1-147[»]
1XXOX-ray1.80A/B1-147[»]
1Y30X-ray2.20A/B1-147[»]
2AQ6X-ray1.70A/B1-147[»]
ProteinModelPortaliO06553.
SMRiO06553. Positions 5-147.

Miscellaneous databases

EvolutionaryTraceiO06553.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 354FMN binding
Regioni34 – 352Pyridoxal phosphate binding
Regioni55 – 573FMN binding
Regioni55 – 573Pyridoxal phosphate binding

Phylogenomic databases

eggNOGiNOG07001.
HOGENOMiHOG000022434.
KOiK07005.
OMAiGRAKVAN.
OrthoDBiEOG6VB6XZ.
PhylomeDBiO06553.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR019920. F420-binding_dom_put.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PfamiPF01243. Pyridox_oxidase. 1 hit.
[Graphical view]
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR03618. Rv1155_F420. 1 hit.

Sequencei

Sequence statusi: Complete.

O06553-1 [UniParc]FASTAAdd to Basket

« Hide

MARQVFDDKL LAVISGNSIG VLATIKHDGR PQLSNVQYHF DPRKLLIQVS    50
IAEPRAKTRN LRRDPRASIL VDADDGWSYA VAEGTAQLTP PAAAPDDDTV 100
EALIALYRNI AGEHSDWDDY RQAMVTDRRV LLTLPISHVY GLPPGMR 147
Length:147
Mass (Da):16,301
Last modified:July 1, 1997 - v1
Checksum:iDAF63639A04D6A0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP43910.1.
PIRiD70555.
RefSeqiNP_215671.1. NC_000962.3.
YP_006514527.1. NC_018143.2.

Genome annotation databases

EnsemblBacteriaiCCP43910; CCP43910; Rv1155.
GeneIDi13319731.
885604.
KEGGimtu:Rv1155.
mtv:RVBD_1155.
PATRICi18151117. VBIMycTub87468_1296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL123456 Genomic DNA. Translation: CCP43910.1 .
PIRi D70555.
RefSeqi NP_215671.1. NC_000962.3.
YP_006514527.1. NC_018143.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1W9A X-ray 1.80 A/B 1-147 [» ]
1XXO X-ray 1.80 A/B 1-147 [» ]
1Y30 X-ray 2.20 A/B 1-147 [» ]
2AQ6 X-ray 1.70 A/B 1-147 [» ]
ProteinModelPortali O06553.
SMRi O06553. Positions 5-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 83332.Rv1155.

Proteomic databases

PRIDEi O06553.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCP43910 ; CCP43910 ; Rv1155 .
GeneIDi 13319731.
885604.
KEGGi mtu:Rv1155.
mtv:RVBD_1155.
PATRICi 18151117. VBIMycTub87468_1296.

Organism-specific databases

TubercuListi Rv1155.

Phylogenomic databases

eggNOGi NOG07001.
HOGENOMi HOG000022434.
KOi K07005.
OMAi GRAKVAN.
OrthoDBi EOG6VB6XZ.
PhylomeDBi O06553.

Enzyme and pathway databases

BioCyci MTBRV:RV1155-MONOMER.

Miscellaneous databases

EvolutionaryTracei O06553.

Family and domain databases

Gene3Di 2.30.110.10. 1 hit.
InterProi IPR019920. F420-binding_dom_put.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR012349. Split_barrel_FMN-bd.
[Graphical view ]
Pfami PF01243. Pyridox_oxidase. 1 hit.
[Graphical view ]
SUPFAMi SSF50475. SSF50475. 1 hit.
TIGRFAMsi TIGR03618. Rv1155_F420. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.
  3. "Structures of Mycobacterium tuberculosispyridoxine 5'-phosphate oxidase and its complexes with flavin mononucleotide and pyridoxal 5'-phosphate."
    Biswal B.K., Cherney M.M., Wang M., Garen C., James M.N.
    Acta Crystallogr. D 61:1492-1499(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH FMN AND PYRIDOXAL PHOSPHATE, SUBUNIT.
  4. "Crystal structure of the conserved hypothetical protein Rv1155 from Mycobacterium tuberculosis."
    Canaan S., Sulzenbacher G., Roig-Zamboni V., Scappuccini-Calvo L., Frassinetti F., Maurin D., Cambillau C., Bourne Y.
    FEBS Lett. 579:215-221(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiY1155_MYCTU
AccessioniPrimary (citable) accession number: O06553
Secondary accession number(s): L0T7G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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