mcr

Functionⁱ

GO - Molecular functionⁱ

alpha-methylacyl-CoA racemase activity
Source: MTBBASE
Inferred from direct assayⁱ
- 15632186
protein homodimerization activity
Source: MTBBASE
Inferred from physical interactionⁱ
- 15632186

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acyl-CoA metabolic process
Source: MTBBASE
Inferred from direct assayⁱ
- 15632186

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCycⁱ	MetaCyc:G185E-5310-MONOMER.
BRENDAⁱ	5.1.99.4. 3445.

Chemistry databases

SwissLipidsⁱ	SLP:000001290.

SwissLipidsⁱ

SLP:000001290.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )Imported
Gene namesⁱ	Name:mcrImported Ordered Locus Names:Rv1143Imported
Organismⁱ	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifierⁱ	83332 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium tuberculosis
Proteomesⁱ	UP000001584 Componentⁱ: Chromosome

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	O06543.

PaxDbⁱ

O06543.

Interactionⁱ

GO - Molecular functionⁱ

protein homodimerization activity
Source: MTBBASE
Inferred from physical interactionⁱ
- 15632186

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	83332.Rv1143.

STRINGⁱ

83332.Rv1143.

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X74	X-ray	1.79	A/B/C/D	1-360	[»]
	2GCE	X-ray	1.85	A/B/C/D	1-360	[»]
	2GCI	X-ray	1.60	A/B/C/D	1-360	[»]
	2GD0	X-ray	1.70	A/B/C/D	1-360	[»]
	2GD2	X-ray	1.70	A/B/C/D	1-360	[»]
	2GD6	X-ray	2.30	A/B/C/D	1-360	[»]
	2YIM	X-ray	1.41	A/B/C/D	1-360	[»]
SMRⁱ	O06543.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG4105C04. Bacteria. COG1804. LUCA.
HOGENOMⁱ	HOG000219744.
KEGG Orthology (KO) More...KOⁱ	K01796.
OMAⁱ	YVASWLF.

Family and domain databases

Gene3Dⁱ	3.40.50.10540. 1 hit.
InterProⁱ	View protein in InterPro IPR003673. CoA-Trfase_fam_III. IPR023606. CoA-Trfase_III_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02515. CoA_transf_3. 1 hit.
SUPFAMⁱ	SSF89796. SSF89796. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

O06543-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGPLSGLRV VELAGIGPGP HAAMILGDLG ADVVRIDRPS SVDGISRDAM 
        60         70         80         90        100
LRNRRIVTAD LKSDQGLELA LKLIAKADVL IEGYRPGVTE RLGLGPEECA 
       110        120        130        140        150
KVNDRLIYAR MTGWGQTGPR SQQAGHDINY ISLNGILHAI GRGDERPVPP 
       160        170        180        190        200
LNLVGDFGGG SMFLLVGILA ALWERQSSGK GQVVDAAMVD GSSVLIQMMW 
       210        220        230        240        250
AMRATGMWTD TRGANMLDGG APYYDTYECA DGRYVAVGAI EPQFYAAMLA 
       260        270        280        290        300
GLGLDAAELP PQNDRARWPE LRALLTEAFA SHDRDHWGAV FANSDACVTP 
       310        320        330        340        350
VLAFGEVHNE PHIIERNTFY EANGGWQPMP APRFSRTASS QPRPPAATID 
       360
IEAVLTDWDG

Length:360

Mass (Da):38,685

Last modified:July 5, 2004 - v3

Checksum:ⁱ52633107358AC843

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL123456 Genomic DNA. Translation: CCP43898.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_215659.1. NC_000962.3. WP_003898740.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaⁱ	AIR13889; AIR13889; LH57_06275. CCP43898; CCP43898; Rv1143.
GeneIDⁱ	885067.
KEGGⁱ	mtu:Rv1143. mtv:RVBD_1143.
PATRICⁱ	fig\|83332.111.peg.1277.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O06543	A0A0Q3Z3E3 A0A0H3L7J6 Q7D8R9 A0A045IZ15 A0A083WCD5 A0A197J2S8 A0A120J0G1 A5U1J1 A0A089S4D8 A0A109SM21 +10	Mycobacterium tuberculosis Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) Mycobacterium bovis Mycobacterium mungi Mycobacterium africanum Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Mycobacterium microti Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) And more	395	UniRef100_A0A0Q3Z3E3	Cluster: Fatty acid-CoA racemase	21

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O06543	A0A0Q3Z3E3 A0A0H3L7J6 Q7D8R9 A0A045IZ15 A0A083WCD5 A0A197J2S8 A0A120J0G1 A5U1J1 A0A089S4D8 A0A109SM21 +14	Mycobacterium tuberculosis Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) Mycobacterium bovis Mycobacterium mungi Mycobacterium africanum Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Mycobacterium microti Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) And more	395	UniRef90_A0A0Q3Z3E3	Cluster: Fatty acid-CoA racemase	25

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O06543	A0A200GYP4 Q742Q0 X8BCF9 UPI0004F6597D UPI000CE4CF48 UPI0004F8032B A0A0E2WAA0 UPI000A015821 A0A0H2ZYV7 A0A049DY10 +229	Mycobacterium paratuberculosis Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) Mycobacterium avium subsp. avium 2285 (R) Mycobacterium avium Mycobacterium avium subsp. hominissuis A5 Mycobacterium avium (strain 104) Mycobacterium avium XTB13-223 Mycobacterium avium 05-4293 Mycobacterium avium 10-5581 Mycobacterium avium subsp. hominissuis And more	359	UniRef50_A0A200GYP4	Cluster: E-cinnamoyl-CoA:R-phenyllactate CoA transferase	240

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL123456 Genomic DNA. Translation: CCP43898.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_215659.1. NC_000962.3. WP_003898740.1. NZ_KK339370.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X74	X-ray	1.79	A/B/C/D	1-360	[»]
	2GCE	X-ray	1.85	A/B/C/D	1-360	[»]
	2GCI	X-ray	1.60	A/B/C/D	1-360	[»]
	2GD0	X-ray	1.70	A/B/C/D	1-360	[»]
	2GD2	X-ray	1.70	A/B/C/D	1-360	[»]
	2GD6	X-ray	2.30	A/B/C/D	1-360	[»]
	2YIM	X-ray	1.41	A/B/C/D	1-360	[»]
SMRⁱ	O06543.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	83332.Rv1143.

STRINGⁱ

83332.Rv1143.

Chemistry databases

SwissLipidsⁱ	SLP:000001290.

SwissLipidsⁱ

SLP:000001290.

Proteomic databases

PaxDbⁱ	O06543.

PaxDbⁱ

O06543.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AIR13889; AIR13889; LH57_06275. CCP43898; CCP43898; Rv1143.
GeneIDⁱ	885067.
KEGGⁱ	mtu:Rv1143. mtv:RVBD_1143.
PATRICⁱ	fig\|83332.111.peg.1277.

Phylogenomic databases

eggNOGⁱ	ENOG4105C04. Bacteria. COG1804. LUCA.
HOGENOMⁱ	HOG000219744.
KEGG Orthology (KO) More...KOⁱ	K01796.
OMAⁱ	YVASWLF.

Enzyme and pathway databases

BioCycⁱ	MetaCyc:G185E-5310-MONOMER.
BRENDAⁱ	5.1.99.4. 3445.

Family and domain databases

Gene3Dⁱ	3.40.50.10540. 1 hit.
InterProⁱ	View protein in InterPro IPR003673. CoA-Trfase_fam_III. IPR023606. CoA-Trfase_III_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02515. CoA_transf_3. 1 hit.
SUPFAMⁱ	SSF89796. SSF89796. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O06543_MYCTU
Accessionⁱ	O06543Primary (citable) accession number: O06543 Secondary accession number(s): I6XAR5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 1, 1997
	Last sequence update:	July 5, 2004
	Last modified:	January 31, 2018
	This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources, Complete proteome, Reference proteomeImported

UniProtKB - O06543 (O06543_MYCTU)

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Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Enzyme and pathway databases

Chemistry databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Proteomic databases

Interactionⁱ

GO - Molecular functionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O06543 (O06543_MYCTU)

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Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )

mcr

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ