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UniProtKB - O06543 (O06543_MYCTU)

UniProt

O06543 - O06543_MYCTU

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Protein
Submitted name:

Carnitine dehydratase

Gene

mcr

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • alpha-methylacyl-CoA racemase activity Source: MTBBASE
  • protein homodimerization activity Source: MTBBASE

GO - Biological processi

  • acyl-CoA metabolic process Source: MTBBASE
Complete GO annotation...

Enzyme and pathway databases

BioCyciMTBRV:RV1143-MONOMER.
BRENDAi5.1.99.4. 3445.

Chemistry

SwissLipidsiSLP:000001290.

Names & Taxonomyi

Protein namesi
Submitted name:
Carnitine dehydrataseImported
Submitted name:
Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )Imported
Gene namesi
Name:mcrImported
Ordered Locus Names:Rv1143Imported
ORF Names:LH57_06275Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: MTBBASE

Protein-protein interaction databases

STRINGi83332.Rv1143.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X74X-ray1.79A/B/C/D1-360[»]
2GCEX-ray1.85A/B/C/D1-360[»]
2GCIX-ray1.60A/B/C/D1-360[»]
2GD0X-ray1.70A/B/C/D1-360[»]
2GD2X-ray1.70A/B/C/D1-360[»]
2GD6X-ray2.30A/B/C/D1-360[»]
2YIMX-ray1.41A/B/C/D1-360[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105C04. Bacteria.
COG1804. LUCA.
HOGENOMiHOG000219744.
KOiK01796.
OMAiAGGSVMC.

Family and domain databases

Gene3Di3.40.50.10540. 1 hit.
InterProiIPR003673. CoA-Trfase_fam_III.
IPR023606. CoA-Trfase_III_dom.
[Graphical view]
PfamiPF02515. CoA_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF89796. SSF89796. 1 hit.

Sequencei

Sequence statusi: Complete.

O06543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPLSGLRV VELAGIGPGP HAAMILGDLG ADVVRIDRPS SVDGISRDAM 
        60         70         80         90        100
LRNRRIVTAD LKSDQGLELA LKLIAKADVL IEGYRPGVTE RLGLGPEECA 
       110        120        130        140        150
KVNDRLIYAR MTGWGQTGPR SQQAGHDINY ISLNGILHAI GRGDERPVPP 
       160        170        180        190        200
LNLVGDFGGG SMFLLVGILA ALWERQSSGK GQVVDAAMVD GSSVLIQMMW 
       210        220        230        240        250
AMRATGMWTD TRGANMLDGG APYYDTYECA DGRYVAVGAI EPQFYAAMLA 
       260        270        280        290        300
GLGLDAAELP PQNDRARWPE LRALLTEAFA SHDRDHWGAV FANSDACVTP 
       310        320        330        340        350
VLAFGEVHNE PHIIERNTFY EANGGWQPMP APRFSRTASS QPRPPAATID 
       360
IEAVLTDWDG
Length:360
Mass (Da):38,685
Last modified:July 5, 2004 - v3
Checksum:i52633107358AC843
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13889.1.
AL123456 Genomic DNA. Translation: CCP43898.1.
RefSeqiNP_215659.1. NC_000962.3.
WP_003898740.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR13889; AIR13889; LH57_06275.
CCP43898; CCP43898; Rv1143.
GeneIDi885067.
KEGGimtu:Rv1143.
mtv:RVBD_1143.
PATRICi18151086. VBIMycTub87468_1281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13889.1.
AL123456 Genomic DNA. Translation: CCP43898.1.
RefSeqiNP_215659.1. NC_000962.3.
WP_003898740.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X74X-ray1.79A/B/C/D1-360[»]
2GCEX-ray1.85A/B/C/D1-360[»]
2GCIX-ray1.60A/B/C/D1-360[»]
2GD0X-ray1.70A/B/C/D1-360[»]
2GD2X-ray1.70A/B/C/D1-360[»]
2GD6X-ray2.30A/B/C/D1-360[»]
2YIMX-ray1.41A/B/C/D1-360[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1143.

Chemistry

SwissLipidsiSLP:000001290.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR13889; AIR13889; LH57_06275.
CCP43898; CCP43898; Rv1143.
GeneIDi885067.
KEGGimtu:Rv1143.
mtv:RVBD_1143.
PATRICi18151086. VBIMycTub87468_1281.

Phylogenomic databases

eggNOGiENOG4105C04. Bacteria.
COG1804. LUCA.
HOGENOMiHOG000219744.
KOiK01796.
OMAiAGGSVMC.

Enzyme and pathway databases

BioCyciMTBRV:RV1143-MONOMER.
BRENDAi5.1.99.4. 3445.

Family and domain databases

Gene3Di3.40.50.10540. 1 hit.
InterProiIPR003673. CoA-Trfase_fam_III.
IPR023606. CoA-Trfase_III_dom.
[Graphical view]
PfamiPF02515. CoA_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF89796. SSF89796. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO06543_MYCTU
AccessioniPrimary (citable) accession number: O06543
Secondary accession number(s): I6XAR5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.