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Protein

Cytolethal distending toxin subunit A

Gene

cdtA

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for the delivery of CdtB.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-822-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytolethal distending toxin subunit A
Short name:
CDT A
Gene namesi
Name:cdtA
Ordered Locus Names:HD_0902
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000001022 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi91 – 911W → G: Abolishes toxicity towards intact cells; when associated with G-98; G-100 and G-102. 1 Publication
Mutagenesisi98 – 981W → G: Abolishes toxicity towards intact cells; when associated with G-91; G-100 and G-102. 1 Publication
Mutagenesisi100 – 1001W → G: Abolishes toxicity towards intact cells; when associated with G-91; G-98 and G-102. 1 Publication
Mutagenesisi102 – 1021Y → G: Abolishes toxicity towards intact cells; when associated with G-91; G-98 and G-100. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515PROSITE-ProRule annotationAdd
BLAST
Chaini16 – 223208Cytolethal distending toxin subunit APRO_0000013371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi16 – 161N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi16 – 161S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Heterotrimer of 3 subunits, CdtA, CdtB and CdtC.1 Publication

Protein-protein interaction databases

STRINGi233412.HD0902.

Structurei

Secondary structure

1
223
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi59 – 613Combined sources
Helixi73 – 764Combined sources
Beta strandi78 – 825Combined sources
Beta strandi85 – 906Combined sources
Beta strandi98 – 1036Combined sources
Helixi104 – 1063Combined sources
Helixi108 – 1147Combined sources
Beta strandi116 – 1205Combined sources
Beta strandi127 – 1315Combined sources
Turni132 – 1343Combined sources
Beta strandi137 – 1415Combined sources
Beta strandi144 – 1485Combined sources
Helixi155 – 1573Combined sources
Beta strandi159 – 1646Combined sources
Beta strandi169 – 1735Combined sources
Turni174 – 1763Combined sources
Beta strandi179 – 1824Combined sources
Beta strandi187 – 1893Combined sources
Beta strandi193 – 1964Combined sources
Beta strandi210 – 2134Combined sources
Beta strandi219 – 2213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SR4X-ray2.00A18-223[»]
ProteinModelPortaliO06522.
SMRiO06522. Positions 57-223.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO06522.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 21290Ricin B-type lectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni91 – 10212Mediates binding to target cellsCuratedAdd
BLAST

Sequence similaritiesi

Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106BMH. Bacteria.
ENOG410Y0HS. LUCA.
KOiK11013.
OMAiHREYFRF.
OrthoDBiPOG091H0LIO.

Family and domain databases

InterProiIPR015957. CDtoxinA.
IPR003558. CDtoxinA/C.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF03498. CDtoxinA. 1 hit.
[Graphical view]
PIRSFiPIRSF036516. CDT_A. 1 hit.
PRINTSiPR01387. CDTOXINA.
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O06522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFLPSLLL MGSVACSSNQ RMNDYSQPES QSDLAPKSST IQPQPQPLLS
60 70 80 90 100
KTPSMSLNLL SSSGPNRQVL PSEPSNFMTL MGQNGALLTV WALAKRNWLW
110 120 130 140 150
AYPNIYSQDF GNIRNWKMEP GKHREYFRFV NQSLGTCVEA YGNGLIHDIC
160 170 180 190 200
SLDKLAQEFE LLPTDSGAVV IKSVSQGRCV TYNPVSTTFY STVTLSVCDG
210 220
ATEPSRDQTW YLAPPVLEAT AVN
Length:223
Mass (Da):24,664
Last modified:July 1, 1997 - v1
Checksum:i5CA68F05958CD56D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53215 Genomic DNA. Translation: AAB57725.1.
AE017143 Genomic DNA. Translation: AAP95786.1.
RefSeqiWP_010944836.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP95786; AAP95786; HD_0902.
GeneIDi24944846.
KEGGihdu:HD_0902.
PATRICi20178201. VBIHaeDuc133973_0743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53215 Genomic DNA. Translation: AAB57725.1.
AE017143 Genomic DNA. Translation: AAP95786.1.
RefSeqiWP_010944836.1. NC_002940.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SR4X-ray2.00A18-223[»]
ProteinModelPortaliO06522.
SMRiO06522. Positions 57-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi233412.HD0902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP95786; AAP95786; HD_0902.
GeneIDi24944846.
KEGGihdu:HD_0902.
PATRICi20178201. VBIHaeDuc133973_0743.

Phylogenomic databases

eggNOGiENOG4106BMH. Bacteria.
ENOG410Y0HS. LUCA.
KOiK11013.
OMAiHREYFRF.
OrthoDBiPOG091H0LIO.

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-822-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO06522.

Family and domain databases

InterProiIPR015957. CDtoxinA.
IPR003558. CDtoxinA/C.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF03498. CDtoxinA. 1 hit.
[Graphical view]
PIRSFiPIRSF036516. CDT_A. 1 hit.
PRINTSiPR01387. CDTOXINA.
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDTA_HAEDU
AccessioniPrimary (citable) accession number: O06522
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.