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O06493

- OPUE_BACSU

UniProt

O06493 - OPUE_BACSU

Protein

Osmoregulated proline transporter

Gene

opuE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the sodium-dependent uptake of extracellular proline.

    GO - Molecular functioni

    1. proline:sodium symporter activity Source: InterPro
    2. sodium ion binding Source: InterPro

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    BioCyciBSUB:BSU06660-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Osmoregulated proline transporter
    Alternative name(s):
    Sodium/proline symporter
    Gene namesi
    Name:opuE
    Synonyms:yerK
    Ordered Locus Names:BSU06660
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU06660. [Micado]

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Osmoregulated proline transporterPRO_0000105404Add
    BLAST

    Proteomic databases

    PaxDbiO06493.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU06660.

    Structurei

    3D structure databases

    ProteinModelPortaliO06493.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0591.
    HOGENOMiHOG000282935.
    KOiK03307.
    OMAiEMVKMGR.
    OrthoDBiEOG6HB9QC.
    PhylomeDBiO06493.

    Family and domain databases

    InterProiIPR011851. Na/Pro_symporter.
    IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02121. Na_Pro_sym. 1 hit.
    TIGR00813. sss. 1 hit.
    PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O06493-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIEIIISLG IYFIAMLLIG WYAFKKTTDI NDYMLGGRGL GPFVTALSAG    50
    AADMSGWMLM GVPGAMFATG LSTLWLALGL TIGAYSNYLL LAPRLRAYTE 100
    AADDAITIPD FFDKRFQHSS SLLKIVSALI IMIFFTLYTS SGMVSGGRLF 150
    ESAFGADYKL GLFLTTAVVV LYTLFGGFLA VSLTDFVQGA IMFAALVLVP 200
    IVAFTHVGGV APTFHEIDAV NPHLLDIFKG ASVISIISYL AWGLGYYGQP 250
    HIIVRFMAIK DIKDLKPARR IGMSWMIITV LGSVLTGLIG VAYAHKFGVA 300
    VKDPEMIFII FSKILFHPLI TGFLLSAILA AIMSSISSQL LVTASAVTED 350
    LYRSFFRRKA SDKELVMIGR LSVLVIAVIA VLLSLNPNST ILDLVGYAWA 400
    GFGSAFGPAI LLSLYWKRMN EWGALAAMIV GAATVLIWIT TGLAKSTGVY 450
    EIIPGFILSM IAGIIVSMIT KRPAKASYRL FGVMEKLLKR KK 492
    Length:492
    Mass (Da):53,283
    Last modified:July 1, 1997 - v1
    Checksum:i23459873F1E799E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92466 Genomic DNA. Translation: AAB66512.1.
    AF011545 Genomic DNA. Translation: AAB72182.1.
    AL009126 Genomic DNA. Translation: CAB12486.1.
    PIRiH69670.
    RefSeqiNP_388548.1. NC_000964.3.
    WP_003242814.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB12486; CAB12486; BSU06660.
    GeneIDi939439.
    KEGGibsu:BSU06660.
    PATRICi18972978. VBIBacSub10457_0703.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92466 Genomic DNA. Translation: AAB66512.1 .
    AF011545 Genomic DNA. Translation: AAB72182.1 .
    AL009126 Genomic DNA. Translation: CAB12486.1 .
    PIRi H69670.
    RefSeqi NP_388548.1. NC_000964.3.
    WP_003242814.1. NZ_CM000487.1.

    3D structure databases

    ProteinModelPortali O06493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU06660.

    Proteomic databases

    PaxDbi O06493.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB12486 ; CAB12486 ; BSU06660 .
    GeneIDi 939439.
    KEGGi bsu:BSU06660.
    PATRICi 18972978. VBIBacSub10457_0703.

    Organism-specific databases

    GenoListi BSU06660. [Micado ]

    Phylogenomic databases

    eggNOGi COG0591.
    HOGENOMi HOG000282935.
    KOi K03307.
    OMAi EMVKMGR.
    OrthoDBi EOG6HB9QC.
    PhylomeDBi O06493.

    Enzyme and pathway databases

    BioCyci BSUB:BSU06660-MONOMER.

    Family and domain databases

    InterProi IPR011851. Na/Pro_symporter.
    IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02121. Na_Pro_sym. 1 hit.
    TIGR00813. sss. 1 hit.
    PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Osmostress response in Bacillus subtilis: characterization of a proline uptake system (OpuE) regulated by high osmolarity and the alternative transcription factor sigma B."
      von Blohn C., Kempf B., Kappes R.M., Bremer E.
      Mol. Microbiol. 25:175-187(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168 / JH642.
    2. "The 52 degrees-55 degrees segment of the Bacillus subtilis chromosome: a region devoted to purine uptake and metabolism, and containing the genes cotA, gabP and guaA and the pur gene cluster within a 34960 bp nucleotide sequence."
      Borriss R., Porwollik S., Schroeter R.
      Microbiology 142:3027-3031(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiOPUE_BACSU
    AccessioniPrimary (citable) accession number: O06493
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3