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O06486 (RFBF_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucose-1-phosphate cytidylyltransferase
EC=2.7.7.33
Alternative name(s):
CDP-glucose pyrophosphorylase
Gene names
Name:yfnH
Ordered Locus Names:BSU07270
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate By similarity.

Catalytic activity

CTP + alpha-D-glucose 1-phosphate = diphosphate + CDP-glucose.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Sequence similarities

Belongs to the glucose-1-phosphate cytidylyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Probable glucose-1-phosphate cytidylyltransferase
PRO_0000389445

Regions

Region6 – 105Substrate binding By similarity
Region11 – 133Substrate binding By similarity

Sites

Metal binding1271Magnesium By similarity
Metal binding2321Magnesium By similarity
Binding site231Substrate By similarity
Binding site1031Substrate; via carbonyl oxygen By similarity
Binding site1081Substrate By similarity
Binding site1261Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
O06486 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 4674B3D79CAEADED

FASTA25428,671
        10         20         30         40         50         60 
MKAVILCGGK GTRMSEVTND IPKPLAMIGG KPILWHIMKI YQYYGVNEFI LLLGYKGEKI 

        70         80         90        100        110        120 
KEYFLDYEWK HNSLTLDSST GEVQMLGQPE TWKITFLETG VDTLTAGRIL QAKDYIGDET 

       130        140        150        160        170        180 
FLLTYGDGLA NINLFHLISY HQTKGAAATV TGIDKVSQFG TLTVEDGMAK TFSEKTSSDG 

       190        200        210        220        230        240 
IINGGFFVLS PKVFDYLPKD GNTMFEDEPL KNLAKDGELA VYRHYGFWTA IDTYKNLLEV 

       250 
NKMWNQGQQV WKVW

« Hide

References

« Hide 'large scale' references
[1]"A 23.4 kb segment at the 69 degrees-70 degrees region of the Bacillus subtilis genome."
Yamamoto H., Uchiyama S., Nugroho F.A., Sekiguchi J.
Microbiology 143:1317-1320(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / AC327.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D86418 Genomic DNA. Translation: BAA20117.1.
AL009126 Genomic DNA. Translation: CAB12546.1.
PIRC69815.
RefSeqNP_388608.1. NC_000964.3.

3D structure databases

HSSPHSSP built from PDB template 1WVC based on UniProtKB P26396.
ProteinModelPortalO06486.
SMRO06486. Positions 2-254.
ModBaseSearch...

Protein-protein interaction databases

STRING224308.BSU07270.

Proteomic databases

PaxDbO06486.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB12546; CAB12546; BSU07270.
GeneID938779.
KEGGbsu:BSU07270.
PATRIC18973104. VBIBacSub10457_0766.

Organism-specific databases

GenoListBSU07270.

Phylogenomic databases

eggNOGCOG1208.
HOGENOMHOG000283474.
KOK00978.
OMAHIMKTYE.
ProtClustDBCLSK886839.

Enzyme and pathway databases

BioCycBSUB:BSU07270-MONOMER.

Family and domain databases

InterProIPR013446. G1P_cyt_trans.
IPR005835. NTP_transferase.
[Graphical view]
PANTHERPTHR22572:SF16. PTHR22572:SF16. 1 hit.
PfamPF00483. NTP_transferase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRFBF_BACSU
AccessionPrimary (citable) accession number: O06486
Secondary accession number(s): Q797B2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: July 1, 1997
Last modified: May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

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