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O06478

- ALDH5_BACSU

UniProt

O06478 - ALDH5_BACSU

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Protein
Putative aldehyde dehydrogenase YfmT
Gene
yfmT, BSU07350
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei253 – 2531 By similarity
Active sitei287 – 2871 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi231 – 2366NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBSUB:BSU07350-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative aldehyde dehydrogenase YfmT (EC:1.2.1.3)
    Gene namesi
    Name:yfmT
    Ordered Locus Names:BSU07350
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU07350.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Putative aldehyde dehydrogenase YfmT
    PRO_0000379510Add
    BLAST

    Proteomic databases

    PaxDbiO06478.

    Expressioni

    Inductioni

    Transcriptionally regulated by SigD; part of the yfmT/yfmS operon.1 Publication

    Interactioni

    Protein-protein interaction databases

    IntActiO06478. 1 interaction.
    MINTiMINT-8366079.
    STRINGi224308.BSU07350.

    Structurei

    3D structure databases

    ProteinModelPortaliO06478.
    SMRiO06478. Positions 8-465.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271509.
    KOiK00128.
    OMAiKGEAPLY.
    OrthoDBiEOG6BS8QW.
    PhylomeDBiO06478.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O06478-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQYEELNKQ FIGGKWQEGS SPNVLENKNP YTQKTFTTFR KATADDVDEA    50
    YRAAALAKKK WDAVNPFEKR TILEKAVTYI EENEEAIIYL IMEELGGTRL 100
    KAAFEIGLVK NIIKEAATFP IRMEGKILPS TIDGKENRLY RVPAGVVGVI 150
    SPFNFPFFLS MKSVAPALGA GNGVVLKPHE ETPICGGTLI AKIFENAGIP 200
    AGLLNVVVTD IAEIGDSFVE HPVPRIISFT GSTKVGSYIG QLAMKHFKKP 250
    LLELGGNSAF IVLEDADIEY AVNAAVFSRF THQGQICMSA NRVLVHSSIY 300
    DKFLELYQAK VESLKVGDPM DPDTIIGPLI NSRQTDGLMK TVEQAIEEGA 350
    VPVKLGGFNG TIVEPTILKD VKPFMSIAKE ELFGPVVSFM KFDSEDEAVD 400
    IANETPFGLS GAVHTSNLER GVAFAKRIET GMIHVNDTTI NDEPNVAFGG 450
    EKQSGLGRLN GEWSLEEFTT LKWISVQHEK RSFPY 485
    Length:485
    Mass (Da):53,321
    Last modified:July 1, 1997 - v1
    Checksum:iC87E9AA12C704B68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86418 Genomic DNA. Translation: BAA20109.1.
    AL009126 Genomic DNA. Translation: CAB12554.1.
    PIRiC69814.
    RefSeqiNP_388616.1. NC_000964.3.
    WP_003244104.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB12554; CAB12554; BSU07350.
    GeneIDi938788.
    KEGGibsu:BSU07350.
    PATRICi18973120. VBIBacSub10457_0774.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86418 Genomic DNA. Translation: BAA20109.1 .
    AL009126 Genomic DNA. Translation: CAB12554.1 .
    PIRi C69814.
    RefSeqi NP_388616.1. NC_000964.3.
    WP_003244104.1. NZ_CM000487.1.

    3D structure databases

    ProteinModelPortali O06478.
    SMRi O06478. Positions 8-465.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi O06478. 1 interaction.
    MINTi MINT-8366079.
    STRINGi 224308.BSU07350.

    Proteomic databases

    PaxDbi O06478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB12554 ; CAB12554 ; BSU07350 .
    GeneIDi 938788.
    KEGGi bsu:BSU07350.
    PATRICi 18973120. VBIBacSub10457_0774.

    Organism-specific databases

    GenoListi BSU07350.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271509.
    KOi K00128.
    OMAi KGEAPLY.
    OrthoDBi EOG6BS8QW.
    PhylomeDBi O06478.

    Enzyme and pathway databases

    BioCyci BSUB:BSU07350-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "A 23.4 kb segment at the 69 degrees-70 degrees region of the Bacillus subtilis genome."
      Yamamoto H., Uchiyama S., Nugroho F.A., Sekiguchi J.
      Microbiology 143:1317-1320(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168 / AC327.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Systematic analysis of SigD-regulated genes in Bacillus subtilis by DNA microarray and Northern blotting analyses."
      Serizawa M., Yamamoto H., Yamaguchi H., Fujita Y., Kobayashi K., Ogasawara N., Sekiguchi J.
      Gene 329:125-136(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, OPERON STRUCTURE.
      Strain: 168.

    Entry informationi

    Entry nameiALDH5_BACSU
    AccessioniPrimary (citable) accession number: O06478
    Secondary accession number(s): Q797A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: July 1, 1997
    Last modified: September 3, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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