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O06478 (ALDH5_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative aldehyde dehydrogenase YfmT

EC=1.2.1.3
Gene names
Name:yfmT
Ordered Locus Names:BSU07350
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Induction

Transcriptionally regulated by SigD; part of the yfmT/yfmS operon. Ref.3

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Putative aldehyde dehydrogenase YfmT
PRO_0000379510

Regions

Nucleotide binding231 – 2366NAD By similarity

Sites

Active site2531 By similarity
Active site2871 By similarity

Sequences

Sequence LengthMass (Da)Tools
O06478 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: C87E9AA12C704B68

FASTA48553,321
        10         20         30         40         50         60 
MFQYEELNKQ FIGGKWQEGS SPNVLENKNP YTQKTFTTFR KATADDVDEA YRAAALAKKK 

        70         80         90        100        110        120 
WDAVNPFEKR TILEKAVTYI EENEEAIIYL IMEELGGTRL KAAFEIGLVK NIIKEAATFP 

       130        140        150        160        170        180 
IRMEGKILPS TIDGKENRLY RVPAGVVGVI SPFNFPFFLS MKSVAPALGA GNGVVLKPHE 

       190        200        210        220        230        240 
ETPICGGTLI AKIFENAGIP AGLLNVVVTD IAEIGDSFVE HPVPRIISFT GSTKVGSYIG 

       250        260        270        280        290        300 
QLAMKHFKKP LLELGGNSAF IVLEDADIEY AVNAAVFSRF THQGQICMSA NRVLVHSSIY 

       310        320        330        340        350        360 
DKFLELYQAK VESLKVGDPM DPDTIIGPLI NSRQTDGLMK TVEQAIEEGA VPVKLGGFNG 

       370        380        390        400        410        420 
TIVEPTILKD VKPFMSIAKE ELFGPVVSFM KFDSEDEAVD IANETPFGLS GAVHTSNLER 

       430        440        450        460        470        480 
GVAFAKRIET GMIHVNDTTI NDEPNVAFGG EKQSGLGRLN GEWSLEEFTT LKWISVQHEK 


RSFPY 

« Hide

References

« Hide 'large scale' references
[1]"A 23.4 kb segment at the 69 degrees-70 degrees region of the Bacillus subtilis genome."
Yamamoto H., Uchiyama S., Nugroho F.A., Sekiguchi J.
Microbiology 143:1317-1320(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / AC327.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Systematic analysis of SigD-regulated genes in Bacillus subtilis by DNA microarray and Northern blotting analyses."
Serizawa M., Yamamoto H., Yamaguchi H., Fujita Y., Kobayashi K., Ogasawara N., Sekiguchi J.
Gene 329:125-136(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, OPERON STRUCTURE.
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86418 Genomic DNA. Translation: BAA20109.1.
AL009126 Genomic DNA. Translation: CAB12554.1.
PIRC69814.
RefSeqNP_388616.1. NC_000964.3.

3D structure databases

ProteinModelPortalO06478.
SMRO06478. Positions 8-465.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO06478. 1 interaction.
MINTMINT-8366079.
STRING224308.BSU07350.

Proteomic databases

PaxDbO06478.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB12554; CAB12554; BSU07350.
GeneID938788.
KEGGbsu:BSU07350.
PATRIC18973120. VBIBacSub10457_0774.

Organism-specific databases

GenoListBSU07350.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271509.
KOK00128.
OMAKGEAPLY.
OrthoDBEOG6BS8QW.
PhylomeDBO06478.

Enzyme and pathway databases

BioCycBSUB:BSU07350-MONOMER.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH5_BACSU
AccessionPrimary (citable) accession number: O06478
Secondary accession number(s): Q797A6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList