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Protein

Alkyl hydroperoxide reductase subunit F

Gene

ahpF

Organism
Xanthomonas campestris pv. phaseoli
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.

Miscellaneous

The active site is a redox-active disulfide bond.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi214 – 229FADBy similarityAdd BLAST16
Nucleotide bindingi356 – 370NAD or NADPBy similarityAdd BLAST15
Nucleotide bindingi477 – 487FADBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl hydroperoxide reductase subunit F (EC:1.8.1.-)
Gene namesi
Name:ahpF
OrganismiXanthomonas campestris pv. phaseoli
Taxonomic identifieri317013 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001667871 – 530Alkyl hydroperoxide reductase subunit FAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi344 ↔ 347Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO06465

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO06465
SMRiO06465
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR012081 Alkyl_hydroperoxide_Rdtase_suF
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR002109 Glutaredoxin
IPR008255 Pyr_nucl-diS_OxRdtase_2_AS
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF13192 Thioredoxin_3, 1 hit
PIRSFiPIRSF000238 AhpF, 1 hit
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF51905 SSF51905, 1 hit
SSF52833 SSF52833, 2 hits
TIGRFAMsiTIGR03140 AhpF, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit
PS00573 PYRIDINE_REDOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O06465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDANLKTQL TAYLERVTRP IQINASIDDS AGSREMLDLL EELVLLSDKI
60 70 80 90 100
SLDIHRDDNQ RKPSFALTTP GQDISLRFAG LPMGHEFTSL VLALLQVGGH
110 120 130 140 150
PSKAAAELIE QVQHLEGDYQ FETYFSLSCQ NCPDVVQALN LAAVLNPRIK
160 170 180 190 200
HVAIDGAWFQ DEVQARQIMS VPTVYLNGEL FDQGRMTLEQ IVAKLDTNAA
210 220 230 240 250
KRDAAKIAAK EAFDVLVVGG GPAGSAAAVY AARKGIRTGV AAERFGGQVL
260 270 280 290 300
DTMSIENFIS VPETEGPKMA AALEQHVRQY DVDIMNLQRA EQLIPAGADG
310 320 330 340 350
LIEIKLANGA SLKSKTVILS TGARWRQMNV PGEDQYKNKG VAYCPHCDGP
360 370 380 390 400
LFKGKRVAVI GGGNSGVEAA IDLAGIVAHV TLVEFDDKLR ADEVLQRKLR
410 420 430 440 450
SLHNVRIITS AQTTEVLGDG QKVTGLVYKD RTGGDIQHIE LEGVFVQIGL
460 470 480 490 500
LPNTEFLRGT VALSPRGEII VDDRGQTDVP GVFAAGDATT VPYKQIVIAM
510 520 530
GEGSKAALSA FDHLIRTSAP ATADSVAQAA
Length:530
Mass (Da):56,922
Last modified:July 1, 1997 - v1
Checksum:iABC1105C8A6FCD24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94336 Genomic DNA Translation: AAC45426.1
RefSeqiWP_039567731.1, NZ_OCZD01000086.1

Similar proteinsi

Entry informationi

Entry nameiAHPF_XANCH
AccessioniPrimary (citable) accession number: O06465
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health