Reviewed, UniProtKB/Swiss-Prot O06456 (PUR6_SULSO)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase catalytic subunit
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:	purE
Ordered Locus Names:	SSO1064

Organism

Sulfolobus solfataricus [Complete proteome] [HAMAP]

Taxonomic identifier

2287 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition By similarity.
Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Phosphoribosylaminoimidazole carboxylase catalytic subunit		PRO_0000074990
Sites
	Binding site	10	1	Substrate By similarity
	Binding site	13	1	Substrate By similarity
	Binding site	40	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O06456-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 3B125E90BF22707A	FASTA	158	17,096
	10 20 30 40 50 60 MPKVAVIMGS KNDWEYMREA VEILKQFGID YEARVVSAHR TPEFMMQYAK EAEKRGIEVI 70 80 90 100 110 120 IAGAGGAAHL PGMVASLTSL PVIGVPIPSK NLNGLDSLLS IVQMPYGVPV ATVAIGGAKN 130 140 150 AALLAIRILG IKYKELADKI KKFSEDMRND VLSTRLEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and sequence analysis of Sulfolobus solfataricus purE and purK genes." Soerensen I.S., Dandanell G. FEMS Microbiol. Lett. 154:173-180(1997) [PubMed: 9311113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y13143 Genomic DNA. Translation: CAA73604.1. AE006641 Genomic DNA. Translation: AAK41327.1.
PIR	H90258.
RefSeq	NP_342537.1.
3D structure databases
HSSP	HSSP built from PDB template 1O4V based on UniProtKB Q9WYS7.
ModBase	Search...
Genome annotation databases
GeneID	1454106.
GenomeReviews	Gene locus SSO1064 in contig AE006641_GR.
KEGG	sso:SSO1064.
NMPDR	fig|273057.1.peg.960.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O06456.
OMA	GVVMGSS.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO1064-MON.
BRENDA	4.1.1.21. 2070.
Family and domain databases
InterPro	IPR000031. AIR_COase_core. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
PANTHER	PTHR23046. AIR_carboxyl. 1 hit.
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
ProDom	PD002193. AIR_carboxyl. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01162. purE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR6_SULSO

Accession

Primary (citable) accession number: O06456

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 1, 1997
Last modified:	November 3, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)