ID   O06362_MYCTO            Unreviewed;       549 AA.
AC   O06362; F2GF18; Q7D553;
DT   01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT   01-JUL-1997, sequence version 1.
DT   27-MAR-2024, entry version 146.
DE   SubName: Full=Adenylate cyclase, putative {ECO:0000313|EMBL:AAK48108.1};
GN   OrderedLocusNames=MT3748 {ECO:0000313|EMBL:AAK48108.1};
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331 {ECO:0000313|EMBL:AAK48108.1, ECO:0000313|Proteomes:UP000001020};
RN   [1] {ECO:0000313|EMBL:AAK48108.1, ECO:0000313|Proteomes:UP000001020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh {ECO:0000313|Proteomes:UP000001020};
RX   PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L.,
RA   Delcher A., Utterback T., Weidman J., Khouri H., Gill J., Mikula A.,
RA   Bishai W., Jacobs Jr W.R.Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; AE000516; AAK48108.1; -; Genomic_DNA.
DR   PIR; F70563; F70563.
DR   RefSeq; WP_003419638.1; NZ_KK341227.1.
DR   AlphaFoldDB; O06362; -.
DR   SMR; O06362; -.
DR   KEGG; mtc:MT3748; -.
DR   PATRIC; fig|83331.31.peg.4033; -.
DR   HOGENOM; CLU_025433_2_0_11; -.
DR   BRENDA; 4.6.1.1; 3445.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IDA:MTBBASE.
DR   GO; GO:0006198; P:cAMP catabolic process; IDA:MTBBASE.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001020};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        85..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        168..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          278..330
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          362..486
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   549 AA;  58759 MW;  28E642515868470B CRC64;
     MDAEAFVGFR QVPAARYGGL MATTAALPRR IHAFVRWVVR TPWPLFSLSM LQSDIIGALF
     VLGFLRYGLP PQDNIQLQDL PPVNLLIFVS TVIILFLAGA VVNLKLLMPV FRWQRRDNLL
     TEPDPAATEL ARSRALRMPL YRTLISLAVW ATGGGVFILA SWSVAKHAAP VVAVATALGA
     TATAIIGYLQ SERVLRPVAV AALRSGVPEN VNAPGVILRL MLAWIPSTGV PLLAIVLAVA
     ADKIALLHAT PEALFNPILM MALAALGIGS VSTLLVAMSI ADPLRQLRWA LSEVQRGNYN
     AHMQIYDASE LGLLQAGFND MVRELSERQR LRDLFGRYVG EDVARRALER GTELGGQERD
     VAVLFVDLVG STQLAATRPP AEVVQLLNEF FRVVVETVAR HGGFVNKFQG DAALAIFGAP
     IEHPDGAGAA LSAARELHDE LIPVLGSAEF GIGVSAGRAI AGHIGAQARF EYTVIGDPVN
     EAARLTELAK LEDGHVLASA IAVSGALDAE ALCWDVGEVV ELRGRAAPTQ LARPMNLAAP
     EEVSSEVRG
//