O06362 (O06362_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Adenylate cyclase, putative EMBL AAK48108.1

Submitted name:
Probable conserved transmembrane protein EMBL CCP46468.1

Gene names

Ordered Locus Names:

MT3748, Rv3645 EMBL CCP46468.1

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane EMBL CCP46468.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from direct assay PubMed 15182360. Source: MTBBASE cAMP catabolic process Inferred from direct assay PubMed 15182360. Source: MTBBASE intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	adenylate cyclase activity Inferred from direct assay PubMed 15182360. Source: MTBBASE signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O06362 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 28E642515868470B	FASTA	549	58,759
	10 20 30 40 50 60 MDAEAFVGFR QVPAARYGGL MATTAALPRR IHAFVRWVVR TPWPLFSLSM LQSDIIGALF 70 80 90 100 110 120 VLGFLRYGLP PQDNIQLQDL PPVNLLIFVS TVIILFLAGA VVNLKLLMPV FRWQRRDNLL 130 140 150 160 170 180 TEPDPAATEL ARSRALRMPL YRTLISLAVW ATGGGVFILA SWSVAKHAAP VVAVATALGA 190 200 210 220 230 240 TATAIIGYLQ SERVLRPVAV AALRSGVPEN VNAPGVILRL MLAWIPSTGV PLLAIVLAVA 250 260 270 280 290 300 ADKIALLHAT PEALFNPILM MALAALGIGS VSTLLVAMSI ADPLRQLRWA LSEVQRGNYN 310 320 330 340 350 360 AHMQIYDASE LGLLQAGFND MVRELSERQR LRDLFGRYVG EDVARRALER GTELGGQERD 370 380 390 400 410 420 VAVLFVDLVG STQLAATRPP AEVVQLLNEF FRVVVETVAR HGGFVNKFQG DAALAIFGAP 430 440 450 460 470 480 IEHPDGAGAA LSAARELHDE LIPVLGSAEF GIGVSAGRAI AGHIGAQARF EYTVIGDPVN 490 500 510 520 530 540 EAARLTELAK LEDGHVLASA IAVSGALDAE ALCWDVGEVV ELRGRAAPTQ LARPMNLAAP EEVSSEVRG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv and H37Rv EMBL CCP46468.1.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP46468.1.
[4]	"TubercuList--10 years after." Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. Tuberculosis 91:1-7(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP46468.1.
[5]	Lew J.M. Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP46468.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000516 Genomic DNA. Translation: AAK48108.1. AL123456 Genomic DNA. Translation: CCP46468.1.
PIR	F70563.
RefSeq	NP_218162.1. NC_000962.3. NP_338294.1. NC_002755.2. YP_006517132.1. NC_018143.1.
3D structure databases
SMR	O06362. Positions 353-508.
ModBase	Search...
Protein-protein interaction databases
STRING	83332.Rv3645.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK48108; AAK48108; MT3748.
GeneID	13317253. 885620. 926496.
KEGG	mtc:MT3748. mtu:Rv3645. mtv:RVBD_3645.
PATRIC	18130000. VBIMycTub22151_4093.
Organism-specific databases
TubercuList	Rv3645.
Phylogenomic databases
HOGENOM	HOG000045754.
KO	K01768.
OMA	DRTMAPG.
ProtClustDB	CLSK792619.
Family and domain databases
Gene3D	3.30.70.1230. 1 hit.
InterPro	IPR001054. A/G_cyclase. IPR003660. HAMP_linker_domain. [Graphical view]
Pfam	PF00211. Guanylate_cyc. 1 hit. PF00672. HAMP. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. SM00304. HAMP. 1 hit. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 1 hit.
PROSITE	PS50125. GUANYLATE_CYCLASE_2. 1 hit. PS50885. HAMP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O06362_MYCTU

Accession

Primary (citable) accession number: O06362
Secondary accession number(s): F2GF18, Q7D553

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 1997
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)