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Protein
Submitted name:

Probable serine protease HtrA (DEGP protein)

Gene

htrA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • growth Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Probable serine protease HtrA (DEGP protein)Imported
Gene namesi
Name:htrAImported
Ordered Locus Names:Rv1223Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1223.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • integral component of plasma membrane Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO06291.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1223.

Structurei

3D structure databases

ProteinModelPortaliO06291.
SMRiO06291. Positions 227-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini440 – 51475PDZ (DHR)InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223641.
OMAiRHPTDAG.
OrthoDBiEOG6ZPT18.
PhylomeDBiO06291.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.

Sequencei

Sequence statusi: Complete.

O06291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRVDTDNA MPARFSAQIQ NEDEVTSDQG NNGGPNGGGR LAPRPVFRPP
60 70 80 90 100
VDPASRQAFG RPSGVQGSFV AERVRPQKYQ DQSDFTPNDQ LADPVLQEAF
110 120 130 140 150
GRPFAGAESL QRHPIDAGAL AAEKDGAGPD EPDDPWRDPA AAAALGTPAL
160 170 180 190 200
AAPAPHGALA GSGKLGVRDV LFGGKVSYLA LGILVAIALV IGGIGGVIGR
210 220 230 240 250
KTAEVVDAFT TSKVTLSTTG NAQEPAGRFT KVAAAVADSV VTIESVSDQE
260 270 280 290 300
GMQGSGVIVD GRGYIVTNNH VISEAANNPS QFKTTVVFND GKEVPANLVG
310 320 330 340 350
RDPKTDLAVL KVDNVDNLTV ARLGDSSKVR VGDEVLAVGA PLGLRSTVTQ
360 370 380 390 400
GIVSALHRPV PLSGEGSDTD TVIDAIQTDA SINHGNSGGP LIDMDAQVIG
410 420 430 440 450
INTAGKSLSD SASGLGFAIP VNEMKLVANS LIKDGKIVHP TLGISTRSVS
460 470 480 490 500
NAIASGAQVA NVKAGSPAQK GGILENDVIV KVGNRAVADS DEFVVAVRQL
510 520
AIGQDAPIEV VREGRHVTLT VKPDPDST
Length:528
Mass (Da):54,190
Last modified:July 5, 2004 - v3
Checksum:iF9C4C6FD6C87BCB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43979.1.
RefSeqiNP_215739.2. NC_000962.3.
WP_003898779.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiCCP43979; CCP43979; Rv1223.
GeneIDi888912.
KEGGimtu:Rv1223.
mtv:RVBD_1223.
PATRICi18124538. VBIMycTub22151_1388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP43979.1.
RefSeqiNP_215739.2. NC_000962.3.
WP_003898779.1. NC_000962.3.

3D structure databases

ProteinModelPortaliO06291.
SMRiO06291. Positions 227-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1223.

Proteomic databases

PaxDbiO06291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP43979; CCP43979; Rv1223.
GeneIDi888912.
KEGGimtu:Rv1223.
mtv:RVBD_1223.
PATRICi18124538. VBIMycTub22151_1388.

Organism-specific databases

TubercuListiRv1223.

Phylogenomic databases

eggNOGiENOG4105C0H. Bacteria.
COG0265. LUCA.
HOGENOMiHOG000223641.
OMAiRHPTDAG.
OrthoDBiEOG6ZPT18.
PhylomeDBiO06291.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiO06291_MYCTU
AccessioniPrimary (citable) accession number: O06291
Secondary accession number(s): F2GFU0, I6Y608, Q8VK49
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 5, 2004
Last modified: April 13, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.