O06249 (O06249_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glutamate decarboxylase EMBL AAK47878.1
EC=4.1.1.15 EMBL AAK47878.1

Submitted name:
Probable glutamate decarboxylase GadB EMBL CCP46254.1

Gene names

Name:	gadB EMBL AAK47878.1
Ordered Locus Names:	MT3538, Rv3432c EMBL CCP46254.1

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000382
Sequence similarities	Belongs to the group II decarboxylase family. RuleBase RU000382

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU000382
Molecular function	Lyase RuleBase RU000382 EMBL AAK47878.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutamate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glutamate decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O06249 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: B5DA3156D4C7CB4F	FASTA	460	50,780
	10 20 30 40 50 60 MSRSHPSVPA HSIAPAYTGR MFTAPVPALR MPDESMDPEA AYRFIHDELM LDGSSRLNLA 70 80 90 100 110 120 TFVTTWMDPE AEKLMAETFD KNMIDKDEYP ATAAIEARCV SMVADLFHAE GLRDHDPTSA 130 140 150 160 170 180 TGVSTIGSSE AVMLGGLALK WRWRQRVGSW KGRMPNLVMG SNVQVVWEKF CRYFDVEPRY 190 200 210 220 230 240 LPMERGRYVI TPEQVLAAVD ENTIGVVAIL GTTYTGELEP IAEICAALDK LAAGGGVDVP 250 260 270 280 290 300 VHVDAASGGF VVPFLHPDLV WDFRLPRVVS INVSGHKYGL TYPGVGFVVW RGPEHLPEDL 310 320 330 340 350 360 VFRVNYLGGD MPTFTLNFSR PGNQVVGQYY NFLRLGRDGY TKVMQALSHT ARWLGDQLRE 370 380 390 400 410 420 VDHCEVISDG SAIPVVSFRL AGDRGYTEFD VSHELRTFGW QVPAYTMPDN ATDVAVLRIV 430 440 450 460 VREGLSADLA RALHDDAVTA LAALDKVKPG GHFDAQHFAH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv and H37Rv EMBL CCP46254.1.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP46254.1.
[4]	"TubercuList--10 years after." Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. Tuberculosis 91:1-7(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP46254.1.
[5]	Lew J.M. Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP46254.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000516 Genomic DNA. Translation: AAK47878.1. AL123456 Genomic DNA. Translation: CCP46254.1.
PIR	F70975.
RefSeq	NP_217949.1. NC_000962.3. NP_338064.1. NC_002755.2. YP_006516921.1. NC_018143.1.
3D structure databases
SMR	O06249. Positions 12-447.
ModBase	Search...
Protein-protein interaction databases
STRING	83332.Rv3432c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK47878; AAK47878; MT3538.
GeneID	13317039. 887580. 922626.
KEGG	mtc:MT3538. mtu:Rv3432c. mtv:RVBD_3432c.
PATRIC	18129513. VBIMycTub22151_3852.
Organism-specific databases
TubercuList	Rv3432c.
Phylogenomic databases
HOGENOM	HOG000070228.
KO	K01580.
OMA	PMDKEHM.
ProtClustDB	CLSK792489.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
InterPro	IPR010107. Glutamate_decarboxylase. IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11999:SF1. PTHR11999:SF1. 1 hit.
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

O06249_MYCTU

Accession

Primary (citable) accession number: O06249
Secondary accession number(s): F2GI04, Q7D5J9

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 1997
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)