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O06249

- O06249_MYCTO

UniProt

O06249 - O06249_MYCTO

Protein

Glutamate decarboxylase

Gene

gadB

Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciMTBRV:RV3432C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadBImported
    Ordered Locus Names:MT3538Imported
    ORF Names:V735_03555Imported
    OrganismiMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)Imported
    Taxonomic identifieri83331 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001020: Chromosome

    Organism-specific databases

    TubercuListiRv3432c.

    Interactioni

    Protein-protein interaction databases

    STRINGi83332.Rv3432c.

    Structurei

    3D structure databases

    SMRiO06249. Positions 12-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiPTFQINF.
    OrthoDBiEOG6TFCPW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O06249-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRSHPSVPA HSIAPAYTGR MFTAPVPALR MPDESMDPEA AYRFIHDELM    50
    LDGSSRLNLA TFVTTWMDPE AEKLMAETFD KNMIDKDEYP ATAAIEARCV 100
    SMVADLFHAE GLRDHDPTSA TGVSTIGSSE AVMLGGLALK WRWRQRVGSW 150
    KGRMPNLVMG SNVQVVWEKF CRYFDVEPRY LPMERGRYVI TPEQVLAAVD 200
    ENTIGVVAIL GTTYTGELEP IAEICAALDK LAAGGGVDVP VHVDAASGGF 250
    VVPFLHPDLV WDFRLPRVVS INVSGHKYGL TYPGVGFVVW RGPEHLPEDL 300
    VFRVNYLGGD MPTFTLNFSR PGNQVVGQYY NFLRLGRDGY TKVMQALSHT 350
    ARWLGDQLRE VDHCEVISDG SAIPVVSFRL AGDRGYTEFD VSHELRTFGW 400
    QVPAYTMPDN ATDVAVLRIV VREGLSADLA RALHDDAVTA LAALDKVKPG 450
    GHFDAQHFAH 460
    Length:460
    Mass (Da):50,780
    Last modified:July 1, 1997 - v1
    Checksum:iB5DA3156D4C7CB4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000516 Genomic DNA. Translation: AAK47878.1.
    JLBH01000003 Genomic DNA. Translation: KBN10368.1.
    PIRiF70975.
    RefSeqiNP_338064.1. NC_002755.2.

    Genome annotation databases

    EnsemblBacteriaiAAK47878; AAK47878; MT3538.
    CCP46254; CCP46254; Rv3432c.
    GeneIDi922626.
    KEGGimtc:MT3538.
    PATRICi18129513. VBIMycTub22151_3852.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000516 Genomic DNA. Translation: AAK47878.1 .
    JLBH01000003 Genomic DNA. Translation: KBN10368.1 .
    PIRi F70975.
    RefSeqi NP_338064.1. NC_002755.2.

    3D structure databases

    SMRi O06249. Positions 12-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 83332.Rv3432c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK47878 ; AAK47878 ; MT3538 .
    CCP46254 ; CCP46254 ; Rv3432c .
    GeneIDi 922626.
    KEGGi mtc:MT3538.
    PATRICi 18129513. VBIMycTub22151_3852.

    Organism-specific databases

    TubercuListi Rv3432c.

    Phylogenomic databases

    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi PTFQINF.
    OrthoDBi EOG6TFCPW.

    Enzyme and pathway databases

    BioCyci MTBRV:RV3432C-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CDC 1551 / OshkoshImported and CDC1551Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CDC1551.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Cdc1551Imported.

    Entry informationi

    Entry nameiO06249_MYCTO
    AccessioniPrimary (citable) accession number: O06249
    Secondary accession number(s): F2GI04, Q7D5J9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 1997
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3