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O06239 (UPPP_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:Rv2136c, MT2194
ORF Names:MTCY270.32
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006

Was identified as a high-confidence drug target. HAMAP-Rule MF_01006

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence CCP44911.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151166

Regions

Transmembrane90 – 11021Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane228 – 24821Helical; Potential
Transmembrane256 – 27621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O06239 [UniParc].

Last modified March 5, 2002. Version 2.
Checksum: 6A85011A4D4214FD

FASTA28230,276
        10         20         30         40         50         60 
MTAAPAMSWW QVIVLAAAQG LTEFLPVSSS GHLAIVSRIF FSGDAGASFT AVSQLGTEAA 

        70         80         90        100        110        120 
VVIYFARDIV RILSAWLHGL VVKAHRNTDY RLGWYVIIGT IPICILGLFF KDDIRSGVRN 

       130        140        150        160        170        180 
LWVVVTALVV FSGVIALAEY VGRQSRHIER LTWRDAVVVG IAQTLALVPG VSRSGSTISA 

       190        200        210        220        230        240 
GLFLGLDREL AARFGFLLAI PAVFASGLFS LPDAFHPVTE GMSATGPQLL VATLIAFVLG 

       250        260        270        280 
LTAVAWLLRF LVRHNMYWFV GYRVLVGTGM LVLLATGTVA AT

« Hide

References

[1]"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. expand/collapse author list , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.
Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[2]"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. expand/collapse author list , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh.
[3]"targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis."
Raman K., Yeturu K., Chandra N.
BMC Syst. Biol. 2:109-109(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL123456 Genomic DNA. Translation: CCP44911.1. Different initiation.
AE000516 Genomic DNA. Translation: AAK46478.1.
PIRD70577.
RefSeqNP_336664.1. NC_002755.2.

3D structure databases

ProteinModelPortalO06239.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv2136c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK46478; AAK46478; MT2194.
GeneID924279.
KEGGmtc:MT2194.
mtu:Rv2136c.
PATRIC18126582. VBIMycTub22151_2404.

Organism-specific databases

TubercuListRv2136c.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAHLAIFTA.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-15232.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. Bacitracin-R_BacA.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_MYCTU
AccessionPrimary (citable) accession number: O06239
Secondary accession number(s): L0TBM1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: May 29, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

SIMILARITY comments

Index of protein domains and families

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