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Protein
Submitted name:

Probable transcriptional regulatory protein (Probably TetR-family)

Gene

Rv2506

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • active evasion of host immune response Source: MTBBASE
  • regulation of transcription, DNA-templated Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6742-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable transcriptional regulatory protein (Probably TetR-family)Imported
Submitted name:
TetR family transcriptional regulatorImported
Gene namesi
Ordered Locus Names:Rv2506Imported
ORF Names:LH57_13720Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-8385665.
STRINGi83332.Rv2506.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 84HTH tetR-type DNA-bindingInterPro annotationAdd BLAST61

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z8Q. Bacteria.
ENOG4111P6M. LUCA.
HOGENOMiHOG000242254.
OMAiEGHIDFA.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O06169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASAPDGRP GQPEATNRRS QLKSDRRFQL LAAAERLFAE RGFLAVRLED
60 70 80 90 100
IGAAAGVSGP AIYRHFPNKE SLLVELLVGV SARLLAGARD VTTRSANLAA
110 120 130 140 150
ALDGLIEFHL DFALGEADLI RIQDRDLAHL PAVAERQVRK AQRQYVEVWV
160 170 180 190 200
GVLRELNPGL AEADARLMAH AVFGLLNSTP HSMKAADSKP ARTVRARAVL
210
RAMTVAALSA ADRCL
Length:215
Mass (Da):23,220
Last modified:July 5, 2004 - v3
Checksum:i645A7BC886019077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15274.1.
AL123456 Genomic DNA. Translation: CCP45300.1.
RefSeqiNP_217022.1. NC_000962.3.
WP_003412790.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR15274; AIR15274; LH57_13720.
CCP45300; CCP45300; Rv2506.
GeneIDi888516.
KEGGimtu:Rv2506.
mtv:RVBD_2506.
PATRICi18154177. VBIMycTub87468_2809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15274.1.
AL123456 Genomic DNA. Translation: CCP45300.1.
RefSeqiNP_217022.1. NC_000962.3.
WP_003412790.1. NZ_KK339370.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8385665.
STRINGi83332.Rv2506.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR15274; AIR15274; LH57_13720.
CCP45300; CCP45300; Rv2506.
GeneIDi888516.
KEGGimtu:Rv2506.
mtv:RVBD_2506.
PATRICi18154177. VBIMycTub87468_2809.

Phylogenomic databases

eggNOGiENOG4108Z8Q. Bacteria.
ENOG4111P6M. LUCA.
HOGENOMiHOG000242254.
OMAiEGHIDFA.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6742-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO06169_MYCTU
AccessioniPrimary (citable) accession number: O06169
Secondary accession number(s): F2GH52, I6XEG8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.