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Reviewed, UniProtKB/Swiss-Prot O06143 (PDTAR_MYCTU)

Last modified February 9, 2010. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable transcriptional regulatory protein pdtaR
Gene names
Name: pdtaR
Ordered Locus Names: Rv1626, MT1662
OrganismMycobacterium tuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

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Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Member of the two-component regulatory system pdtaR/pdtaS. Ref.3

Subunit structure

Monomer. Dimer; when bound to its cognate DNA Potential. Ref.4

Post-translational modification

Phosphorylated by pdtaS. Ref.3

Sequence similarities

Contains 1 ANTAR domain.

Contains 1 response regulatory domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Probable transcriptional regulatory protein pdtaR
PRO_0000386597

Regions

Domain15 – 129115Response regulatory
Domain135 – 19662ANTAR

Amino acid modifications

Modified residue6514-aspartylphosphate By similarity

Secondary structure

1 ............................ 205
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
O06143-1 [UniParc].

Last modified July 5, 2004. Version 3.
Checksum: C57AD16BAD0E3C0B

FASTA20522,669
        10         20         30         40         50         60 
MTGPTTDADA AVPRRVLIAE DEALIRMDLA EMLREEGYEI VGEAGDGQEA VELAELHKPD 

        70         80         90        100        110        120 
LVIMDVKMPR RDGIDAASEI ASKRIAPIVV LTAFSQRDLV ERARDAGAMA YLVKPFSISD 

       130        140        150        160        170        180 
LIPAIELAVS RFREITALEG EVATLSERLE TRKLVERAKG LLQTKHGMTE PDAFKWIQRA 

       190        200 
AMDRRTTMKR VAEVVLETLG TPKDT

« Hide

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References

« Hide 'large scale' references
[1]"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. expand/collapse author list , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.
Nature 393:537-544(1998) [PubMed: 9634230] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[2]"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. expand/collapse author list , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh.
[3]"A novel two-component system found in Mycobacterium tuberculosis."
Morth J.P., Gosmann S., Nowak E., Tucker P.A.
FEBS Lett. 579:4145-4148(2005) [PubMed: 16026786] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION.
Strain: ATCC 25618 / H37Rv.
[4]"The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis."
Morth J.P., Feng V., Perry L.J., Svergun D.I., Tucker P.A.
Structure 12:1595-1605(2004) [PubMed: 15341725] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS), SUBUNIT.
Strain: ATCC 25618 / H37Rv.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842577 Genomic DNA. Translation: CAB08879.1.
AE000516 Genomic DNA. Translation: AAK45932.1. Different initiation.
PIRH70558.
RefSeqNP_216142.1.
NP_336118.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1S8NX-ray1.48A1-205[»]
1SD5X-ray1.68A1-205[»]
ModBaseSearch...

Genome annotation databases

GeneID885080.
924202.
GenomeReviewsGene locus MT1662 in contig AE000516_GR.
KEGGmtu:Rv1626.
TIGRMT1662.

Organism-specific databases

TubercuListRv1626.

Phylogenomic databases

HOGENOMHBG753323.

Family and domain databases

InterProIPR005561. AmiR_NasR_reg.
IPR011006. CheY-like.
IPR008327. Sig_transdc_resp-reg_antiterm.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PfamPF03861. ANTAR. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFPIRSF036382. RR_antiterm. 1 hit.
SMARTSM00448. REC. 1 hit.
[Graphical view]
PROSITEPS50921. ANTAR. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePDTAR_MYCTU
AccessionPrimary (citable) accession number: O06143
Secondary accession number(s): Q7D890
Entry history
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: July 5, 2004
Last modified: February 9, 2010
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents