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O06069 (ILVD_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:ML2608
ORF Names:MLCL622.06c
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Dihydroxy-acid dehydratase HAMAP MF_00012
PRO_0000103480

Sites

Metal binding1261Iron-sulfur (4Fe-4S) Potential
Metal binding2031Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
O06069 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 23E5782F003536B5

FASTA56458,783
        10         20         30         40         50         60 
MMPPDIKPRS RDVTDGLEKA AARGMLRAVG MNDDDFAKAQ IGVASSWNEI TPCNLSLDRL 

        70         80         90        100        110        120 
AKAVKEGVFS AGGYPLEFGT ISVSDGISMG HQGMHFSLVS REVIADSVET VMQAERLDGS 

       130        140        150        160        170        180 
VLLAGCDKSL PGMLMAAARL DLASVFLYAG SILPGRTKLS DGTEHEVTLI DAFEAVGACS 

       190        200        210        220        230        240 
RGLMPRADVD AIERAICPGE GACGGMYTAN TMASAAEALG MSLPGSAAPP ATDRRRDGFA 

       250        260        270        280        290        300 
RRSGQAVIEL LRRGITARDI LTKEAFENAI AVVMAFGGST NAILHLLAIA HEADVTLSLE 

       310        320        330        340        350        360 
DFSRIGFKVP HIADVKPFGR HVMFDVDHIG GVPVVMKALL DAGLLHGDCL TVTGQTMAEN 

       370        380        390        400        410        420 
LASIAPPDPD GQVIRTLHNP IHPTGGITIL RGSLAPDGAV VKTAGLDSDV FEGTARVFDG 

       430        440        450        460        470        480 
ERAALDALKD GTIAKGDVVV IRYEGPKGGP GMREMLAITG AIKGAGLGKD VLLLTDGRFS 

       490        500        510        520        530        540 
GGTTGFCVGH IAPEAVEAGP IAFLRDGDRV LLDVVGCSLD VLVDPVEFSS RKKDFIPPAP 

       550        560 
RYTTGVLAKY VKLVSSATVG AVCG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z95398 Genomic DNA. Translation: CAB08798.1.
AL583926 Genomic DNA. Translation: CAC32140.1.
PIRF87235.
RefSeqNP_302670.1. NC_002677.1.

3D structure databases

ProteinModelPortalO06069.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028792; EBMYCP00000028398; EBMYCG00000028787.
GeneID910866.
GenomeReviewsGene locus ML2608 in contig AL450380_GR.
KEGGmle:ML2608.
NMPDRfig|272631.1.peg.1542.
PATRIC18060173. VBIMycLep78757_5000.

Organism-specific databases

LepromaML2608.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016366.
HOGENOMHBG671001.
OMANMPGAMI.
ProtClustDBPRK00911.

Enzyme and pathway databases

BioCycMLEP272631:ML2608-MONOMER.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_MYCLE
AccessionPrimary (citable) accession number: O06069
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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