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O06024 (O06024_KLEPN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Beta lactamase SHV-11 EMBL AFK94615.1
Submitted name:
Beta-lactamase EMBL AAS98183.1
Submitted name:
Beta-lactamase SHV-11 EMBL ACV03882.1
Submitted name:
Beta-lactamase SHV-1a EMBL CAA66729.1
Submitted name:
Beta-lactamase blaSHV-11 EMBL ACV33196.1
Submitted name:
Extended-spectrum beta-lactamase SHV-11 EMBL ABB01157.1
Submitted name:
SHV extended-spectrum beta-lactamase EMBL ABI20752.1
Submitted name:
SHV-11 EMBL AEW43356.1
Submitted name:
SHV-11 beta-lactamase EMBL ACM04455.1
Submitted name:
SHV-type extended spectrum beta-lactamase EMBL AFC38858.1
Gene names
Name:blaSHV-1a EMBL CAA66729.1
Synonyms:blaSHV EMBL ACV33196.1, blaSHV-11 EMBL AAS98183.1, blaSHV11 EMBL ACO07067.1, SHV-11 EMBL AAZ98824.3
Encoded onPlasmid pKP137 Ref.3 EMBL AAZ98827.3
Plasmid unnamed Ref.4 Ref.13 Ref.19 EMBL ABI20752.1 EMBL ADA61019.1
Plasmid pKP23 Ref.3 EMBL AAZ98824.3
Plasmid pIncX-SHV Ref.18 EMBL AEW43356.1
OrganismKlebsiella pneumoniae EMBL CAA66729.1
Taxonomic identifier573 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid. SAAS SAAS000871

Ontologies

Keywords
   Biological processAntibiotic resistance SAAS SAAS000871
   Molecular functionHydrolase SAAS SAAS000871
   Technical termPlasmid EMBL AAZ98824.3
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
O06024 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: FDBF426DA7698E6B

FASTA28631,239
        10         20         30         40         50         60 
MRYIRLCIIS LLATLPLAVH ASPQPLEQIK QSESQLSGRV GMIEMDLASG RTLTAWRADE 

        70         80         90        100        110        120 
RFPMMSTFKV VLCGAVLARV DAGDEQLERK IHYRQQDLVD YSPVSEKHLA DGMTVGELCA 

       130        140        150        160        170        180 
AAITMSDNSA ANLLLATVGG PAGLTAFLRQ IGDNVTRLDR WETELNEALP GDARDTTTPA 

       190        200        210        220        230        240 
SMAATLRKLL TSQRLSARSQ RQLLQWMVDD RVAGPLIRSV LPAGWFIADK TGAGERGARG 

       250        260        270        280 
IVALLGPNNK AERIVVIYLR DTPASMAERN QQIAGIGAAL IEHWQR

« Hide

References

[1]"Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12."
Nuesch-Inderbinen M., Kayser F.H., Hachler H.
Antimicrob. Agents Chemother. 41:943-949(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: KPZU-12 EMBL CAA66729.1.
[2]"SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae."
Dubois V., Poirel L., Arpin C., Coulange L., Bebear C., Nordmann P., Quentin C.
Antimicrob. Agents Chemother. 48:4466-4469(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"A study on a novel SHV type extended spectrum beta-lactamase."
Li J., Cheng J., Li H., Wang Y.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: KPn137 EMBL AAZ98827.3 and Kpn23 EMBL AAZ98824.3.
[4]Hu G.-Z., Fu X.-L., Chen H.-Y., Yuan L., Liu J.-H., Mo J., Pan Y.-S.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 9 EMBL ABI20752.1.
[5]"SHV beta lactamase gene produced by Gram-negative bacteria isolated from AIIMS hospital, India."
Lal P., Kapil A., Das B.K.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Kp279 EMBL ABM89161.1, Kp282 EMBL ABM89159.1, Kp307 EMBL ABM89158.1, Kp775 EMBL ABM89162.1, Kp811 EMBL ABM89163.1 and Kp962 EMBL ABM89164.1.
[6]"Differential expression of bla(SHV) related to susceptibility to ampicillin in Klebsiella pneumoniae."
Fu Y., Zhang F., Zhang W., Chen X., Zhao Y., Ma J., Bao L., Song W., Ohsugi T., Urano T., Liu S.
Int. J. Antimicrob. Agents 29:344-347(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 724 EMBL ABB01162.1, 751 EMBL ABB01157.1, 752 EMBL ABB01158.1, 757 EMBL ABB01160.1 and 763 EMBL ABB01161.1.
[7]"Dominance of blaCTX-M within an Australian extended-spectrum beta-lactamase gene pool."
Zong Z., Partridge S.R., Thomas L., Iredell J.R.
Antimicrob. Agents Chemother. 52:4198-4202(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JIE091 EMBL ACM04455.1.
[8]"Diversity of TEM-, SHV- and CTX-M-Type Beta-Lactamases Present in Clinical Isolates of Klebsiella pneumoniae from a Brazilian Hospital."
Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HB 1 EMBL ACV03882.1.
[9]"Diversity of TEM-, SHV-, and CTX-M- Type beta-Lactamases Present in Clinical Isolates of Klebsiella pneumoniae from a Brazilian Hospital."
Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HB 20 EMBL ACV33196.1, HB 33 EMBL ACV33202.1, HB 35 EMBL ACV33204.1, HB 67 EMBL ACV33205.1, HB 79 EMBL ACV33213.1, HB 83 EMBL ACV33217.1, HB 96 EMBL ACV33228.1 and HB 98 EMBL ACV33230.1.
[10]"Diversity of TEM-, SHV-, CTX-M-Type Beta-Lactamases Present in Clinical Isolates of Klebsiella pneumoniae from a Brazilian Hospital."
Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HB 13 EMBL ACV32618.1, HB 14 EMBL ACV32619.1, HB 15 EMBL ACV32620.1, HB 16 EMBL ACV32621.1, HB 17 EMBL ACV32622.1 and HB 18 EMBL ACV32623.1.
[11]"Diversity of TEM-, SHV-, and CTX-M- type beta-lactamases present in clinical isolates of Klebsiella pneumoniae from a Brazilian hospital."
Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HB 40 EMBL ACY68230.1, HB 47 EMBL ACY68231.1, HB 50 EMBL ACY68232.1, HB 58 EMBL ACY68233.1, HB 62 EMBL ACY68234.1, HB 64 EMBL ACY68235.1 and HB 66 EMBL ACY68237.1.
[12]"Diversity of TEM-, SHV-, and CTX-M- type beta-lactamases present in clinical isolates of Klebsiella pneumoniae from a Brazilian hospital."
Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HB 49 EMBL ACY68239.1.
[13]"SHV-11 in Klebsiella pneumoniae isolated from chickens in China."
Hu G.-Z., Liu B.-G., Yuan L., Liu J.-H., Pan Y.-S., Mo J., Xu R., Xu L.-N., Wei Y.-J., Xiao S.-X.
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 2 EMBL ADA61019.1.
[14]"Prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil."
Veras D.L., Alves L.C., Brayner F.A., Guedes D.R., Maciel M.A., Rocha C.R., de Souza Lopes A.C.
Curr. Microbiol. 62:1610-1616(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: K10C EMBL ADR80604.1 and K3C EMBL ADK63437.1.
[15]"Duplication of the chromosomal blaSHV-11 gene in a clinical hypermutable strain of Klebsiella pneumoniae."
Duvernay C., Coulange L., Dutilh B., Dubois V., Quentin C., Arpin C.
Microbiology 157:496-503(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Kp869 EMBL ACV91691.1.
[16]"Phenotypic and genotypic characterization of ?-lactam resistance in Klebsiella pneumoniae isolated from swine."
Zou L.K., Wang H.N., Zeng B., Zhang A.Y., Li J.N., Li X.T., Tian G.B., Wei K., Zhou Y.S., Xu C.W., Yang Z.R.
Vet. Microbiol. 149:139-146(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Ems-c2 EMBL ACO07067.1.
[17]"High Genetic Diversity of Extended-Spectrum Beta-Lactamase-Positive Bacterial Isolates in South-Eastern Austria."
Barisic I.
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 10/134 EMBL AEZ49594.1.
[18]"Klebsiella pneumoniae ST258 Producing KPC-3 Identified in Italy Carries Novel Plasmids and OmpK36/OmpK35 Porin Variants."
Garcia-Fernandez A., Villa L., Carta C., Venditti C., Giordano A., Venditti M., Mancini C., Carattoli A.
Antimicrob. Agents Chemother. 56:2143-2145(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[19]"Phenotypic and molecular characterization of CTX-M-14 extended-spectrum ?-lactamase and plasmid-mediated ACT-like AmpC ?-lactamase produced by Klebsiella pneumoniae isolates from chickens in Henan Province, China."
Wu H., Liu B.G., Liu J.H., Pan Y.S., Yuan L., Hu G.Z.
Genet. Mol. Res. 11:3357-3364(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 2 EMBL ADA61019.1.
[20]"Phenotypic and Genotypic characterization of E. coli and Klebsiella pneumoniae isolates from tertiary hospital in Chennai, India."
Vaidyanathan V., Srinivasan V.B., Govindan R.
Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: KP-3 EMBL AFC38858.1.
[21]Casella T., Takahashi J.T., Mataruco M.M., Colombo T.E., Nogueira M.L., Nogueira M.C.L.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BR2011/S105 EMBL AFK94615.1.
[22]"Emergence of several beta-lactamases in Austria."
Barisic I., Mitteregger D., Goekler D., Hirschl A., Noehammer C., Wiesinger-Mayr H.
Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: AKH11/10 EMBL AFN82167.1, AKH11/33 EMBL AFN82173.1, AKH11/44 EMBL AFN82065.1, AKH11/50 EMBL AFN82163.1, AKH11/7 EMBL AFN82159.1, AKH11/C1 EMBL AFN82166.1, AKH11/C12 EMBL AFN82180.1, AKH11/C19 EMBL AFN82181.1, AKH11/C2 EMBL AFN82182.1, AKH11/C25 EMBL AFN82178.1, AKH11/C26 1 EMBL AFN82177.1, AKH11/C30 EMBL AFN82176.1, AKH11/C31 EMBL AFN82175.1, AKH11/C33 EMBL AFN82174.1, AKH11/C34 EMBL AFN82172.1, AKH11/C38 EMBL AFN82171.1, AKH11/C49 EMBL AFN82164.1, AKH11/C50 EMBL AFN82168.1, AKH11/C52 EMBL AFN82162.1 and AKH11/C9 EMBL AFN82157.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY528717 Genomic DNA. Translation: AAS98183.1.
DQ166779 Genomic DNA. Translation: AAZ98824.3.
DQ166782 Genomic DNA. Translation: AAZ98827.3.
DQ219472 Genomic DNA. Translation: ABB01157.1.
DQ219473 Genomic DNA. Translation: ABB01158.1.
DQ219475 Genomic DNA. Translation: ABB01160.1.
DQ219476 Genomic DNA. Translation: ABB01161.1.
DQ219477 Genomic DNA. Translation: ABB01162.1.
DQ849331 Genomic DNA. Translation: ABI20752.1.
EF035557 Genomic DNA. Translation: ABM89158.1.
EF035558 Genomic DNA. Translation: ABM89159.1.
EF035560 Genomic DNA. Translation: ABM89161.1.
EF035561 Genomic DNA. Translation: ABM89162.1.
EF035562 Genomic DNA. Translation: ABM89163.1.
EF035563 Genomic DNA. Translation: ABM89164.1.
EU418909 Genomic DNA. Translation: ACM04455.1.
FJ685655 Genomic DNA. Translation: ACO07067.1.
GQ387358 Genomic DNA. Translation: ACV03882.1.
GQ389702 Genomic DNA. Translation: ACV32618.1.
GQ389703 Genomic DNA. Translation: ACV32619.1.
GQ389704 Genomic DNA. Translation: ACV32620.1.
GQ389705 Genomic DNA. Translation: ACV32621.1.
GQ389706 Genomic DNA. Translation: ACV32622.1.
GQ389707 Genomic DNA. Translation: ACV32623.1.
GQ407109 Genomic DNA. Translation: ACV33196.1.
GQ407115 Genomic DNA. Translation: ACV33202.1.
GQ407117 Genomic DNA. Translation: ACV33204.1.
GQ407118 Genomic DNA. Translation: ACV33205.1.
GQ407126 Genomic DNA. Translation: ACV33213.1.
GQ407130 Genomic DNA. Translation: ACV33217.1.
GQ407141 Genomic DNA. Translation: ACV33228.1.
GQ407143 Genomic DNA. Translation: ACV33230.1.
GQ463147 Genomic DNA. Translation: ACV91691.1.
GQ463148 Genomic DNA. Translation: ACV91699.1.
GU064383 Genomic DNA. Translation: ACY68230.1.
GU064384 Genomic DNA. Translation: ACY68231.1.
GU064385 Genomic DNA. Translation: ACY68232.1.
GU064386 Genomic DNA. Translation: ACY68233.1.
GU064387 Genomic DNA. Translation: ACY68234.1.
GU064388 Genomic DNA. Translation: ACY68235.1.
GU064390 Genomic DNA. Translation: ACY68237.1.
GU064392 Genomic DNA. Translation: ACY68239.1.
GU211012 Genomic DNA. Translation: ADA61019.1.
HM363638 Genomic DNA. Translation: ADK63437.1.
HM751098 Genomic DNA. Translation: ADR80604.1.
JN247852 Genomic DNA. Translation: AEW43356.1.
JN676878 Genomic DNA. Translation: AEZ49594.1.
JQ416147 Genomic DNA. Translation: AFC38858.1.
JQ723521 Genomic DNA. Translation: AFK94615.1.
JX268636 Genomic DNA. Translation: AFN82065.1.
JX268728 Genomic DNA. Translation: AFN82157.1.
JX268730 Genomic DNA. Translation: AFN82159.1.
JX268733 Genomic DNA. Translation: AFN82162.1.
JX268734 Genomic DNA. Translation: AFN82163.1.
JX268735 Genomic DNA. Translation: AFN82164.1.
JX268737 Genomic DNA. Translation: AFN82166.1.
JX268738 Genomic DNA. Translation: AFN82167.1.
JX268739 Genomic DNA. Translation: AFN82168.1.
JX268742 Genomic DNA. Translation: AFN82171.1.
JX268743 Genomic DNA. Translation: AFN82172.1.
JX268744 Genomic DNA. Translation: AFN82173.1.
JX268745 Genomic DNA. Translation: AFN82174.1.
JX268746 Genomic DNA. Translation: AFN82175.1.
JX268747 Genomic DNA. Translation: AFN82176.1.
JX268748 Genomic DNA. Translation: AFN82177.1.
JX268749 Genomic DNA. Translation: AFN82178.1.
JX268751 Genomic DNA. Translation: AFN82180.1.
JX268752 Genomic DNA. Translation: AFN82181.1.
JX268753 Genomic DNA. Translation: AFN82182.1.
X98101 Genomic DNA. Translation: CAA66729.1.
RefSeqYP_006959014.1. NC_019157.1.

3D structure databases

HSSPHSSP built from PDB template 1ONG based on UniProtKB P14557.
ProteinModelPortalO06024.
SMRO06024. Positions 22-286.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID13914642.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. PBP_transp_fold. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameO06024_KLEPN
AccessionPrimary (citable) accession number: O06024
Secondary accession number(s): Q3S4T3
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info