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Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 12901257Sequence analysisPRO_5004156810Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO06021.
SMRiO06021. Positions 391-847.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1017 – 1290274Autotransporter (TC 1.B.12)InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O06021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT
60 70 80 90 100
GAAVGTVSGL LSWGLKQAEE ANKTPDKPDK VWRIQAGRGF NNFPHKEYDL
110 120 130 140 150
YKSLLSSKID GGWDWGNAAR HYWVKGGQWN KLEVDMKDAV GTYKLSGLIN
160 170 180 190 200
FTGGDLDVNM QKATLRLGQF NGNSFTSYKD SADRTTRVDF NAKNILIDNF
210 220 230 240 250
LEINNRVGSG AGRKASSTVL TLQASEGITS SKNAEISLYD GATLNLASSS
260 270 280 290 300
VKLMGNVWMG RLQYVGAYLA PSYSTINTSK VTGEVNFNHL TVGDHNAAQA
310 320 330 340 350
GIIASNKTHI GTLDLWQSAG LNIIAPPEGG YKDKPKDKPS NTTQNNANNN
360 370 380 390 400
QQNSAQNNNN TQVINPPNSA QKTEIQPTQV INGPFGGGKD TVVNINRINT
410 420 430 440 450
NADGTIRVGG YKASLTTNAA HLHIGKGGIN LSNQASGRSL LVENLTGNIT
460 470 480 490 500
VDGPLRVNNQ VGGYALAGSN ANFEFKAGTD TKNGTATFNN DISLGRFGNL
510 520 530 540 550
KVDAHTANFK GIDTGNGGFT TLDFCGVTDK VIINKLITAS TNVAIKNSNI
560 570 580 590 600
NDLLVTTNGV SVGEYTHFSE DIGSQSRINT VRLETGTRSI FSGGVKFKSG
610 620 630 640 650
EKLVIDEFYY SPWNYLDARN IKNVEITRKF ASSTPENPWG TSKLMFNNLT
660 670 680 690 700
LGQNAAMDYS QFSNLTIQGD FINNQGTINY LVRGGKVATL NVGNAAAMMF
710 720 730 740 750
NNDIDSATGF YKPLIKINSA QDLIKNTEHV LLKAKIIGYG NVSTGTNGIS
760 770 780 790 800
NVNLEEQFKG RLALYNNNNR MDTCVVRNTD DIKACGMAIG NQSMVTTPDN
810 820 830 840 850
YKYLIGKAWK NIGISKTANG SKISVYYLGN STPTENGGNT TNLPTNTTNS
860 870 880 890 900
ARSANYALVK NAPFAHSATP NLVAINQHEC GTIESVCELA NRSKDIDTLY
910 920 930 940 950
THSGAKGRDL LQTLLIDSHD AGYVRQMIDN TSTGEITKQL NAATTTLNNI
960 970 980 990 1000
ASLEHKTSSL QTLSLSNAMI LNSRLVNLSR KHTNNIDSFA KRLQALKDQR
1010 1020 1030 1040 1050
FASLESAAEV LYQFAPKYEK PTNVWANAIG GASLNNGSNA SLYGTSAGVD
1060 1070 1080 1090 1100
AYLNGQVEAI VGGFGSYGYS SFSNRANSLN SGTNNTNCGV YSRIFANQHE
1110 1120 1130 1140 1150
FDFEAQGALG SDQSSLNFKS ALLQDLNQSY NYLAYSAATR ASYGYDFAFF
1160 1170 1180 1190 1200
KNALVLTPSV GVSYNHLGST NFKSNSTNKV ALSNGSSSQH LFNASANVEA
1210 1220 1230 1240 1250
RYYYGDTSYF YMNAGVLQEF ANFGSSNAVS LNTFKVNAAR NPLNTHPRVM
1260 1270 1280 1290
MGGEFQLAKE VFLNLGFVYL HNLISNIGHF ASNLGMRYSF
Length:1,290
Mass (Da):139,182
Last modified:July 1, 1997 - v1
Checksum:i625406E581580578
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001358 Genomic DNA. Translation: AAB53868.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001358 Genomic DNA. Translation: AAB53868.1.

3D structure databases

ProteinModelPortaliO06021.
SMRiO06021. Positions 391-847.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO06021_HELPX
AccessioniPrimary (citable) accession number: O06021
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: March 16, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.