O05982 (KCY_SULAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Synonyms:	cdk
Ordered Locus Names:	Saci_0570

Organism

Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) [Complete proteome] [HAMAP]

Taxonomic identifier

330779 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00239
Subcellular location	Cytoplasm By similarity HAMAP MF_00239.
Sequence similarities	Belongs to the cytidylate kinase family. Type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro shikimate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Cytidylate kinase HAMAP MF_00239		PRO_0000132023
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity
Experimental info
	Sequence conflict	175 – 182	8	NLHSALSH → TYTRLCGIDLLNIYPE in CAA73486. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O05982 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: CD5C42C3906377AD	FASTA	182	20,696
	10 20 30 40 50 60 MKIIISGPPG SGKSSVAKIL SSKLSIKYVS AGLIFRDLAK RMNIDIVKLN KLAEDDFEID 70 80 90 100 110 120 KKIDLEMFKL IKSQDNVIIE SHIGGWLFHN LSDLSIYLRA PLDVRAKRIA SRDHISEDEA 130 140 150 160 170 180 IIQIIKRERS HRERFLRYYG IDILDLSVFD LVINTSYLLP EDVADIILGV ISRKNLHSAL SH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The downstream region of the Sulfolobus adk gene comprises the r134- and the cytidylate kinase gene." Kath T., Schaefer G., Moll R. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
[2]	"The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota." Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A. J. Bacteriol. 187:4992-4999(2005) [PubMed: 15995215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y13049 Genomic DNA. Translation: CAA73486.1. CP000077 Genomic DNA. Translation: AAY79962.1.
RefSeq	YP_255255.1. NC_007181.1.
3D structure databases
ProteinModelPortal	O05982.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3473208.
GenomeReviews	Gene locus Saci_0570 in contig CP000077_GR.
KEGG	sai:Saci_0570.
NMPDR	fig|330779.3.peg.1810.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG578180.
OMA	CAGFIFR.
ProtClustDB	PRK04182.
Enzyme and pathway databases
BioCyc	SACI330779:SACI_0570-MONOMER.
Family and domain databases
HAMAP	MF_00239. Cytidyl_kinase_type2. [Tree]
InterPro	IPR011892. Cyt_kin_arch. IPR000623. Shikimate_kinase. [Graphical view]
KO	K00945.
Pfam	PF01202. SKI. 1 hit. [Graphical view]
TIGRFAMs	TIGR02173. Cyt_kin_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_SULAC

Accession

Primary (citable) accession number: O05982
Secondary accession number(s): Q4JB67

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 30, 2005
Last modified:	January 25, 2012
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program