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O05973

- UDG_RICPR

UniProt

O05973 - UDG_RICPR

Protein

UDP-glucose 6-dehydrogenase

Gene

udg

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei260 – 2601By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi2 – 1918NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide biosynthetic process Source: InterPro
    2. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00038; UER00491.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
    Short name:
    UDP-Glc dehydrogenase
    Short name:
    UDP-GlcDH
    Short name:
    UDPGDH
    Gene namesi
    Name:udg
    Ordered Locus Names:RP779
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434UDP-glucose 6-dehydrogenasePRO_0000074052Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP779.

    Structurei

    3D structure databases

    ProteinModelPortaliO05973.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1004.
    HOGENOMiHOG000153773.
    KOiK00012.
    OMAiRETNPTA.
    OrthoDBiEOG6ZSP7N.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028357. UDPglc_DH_bac.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O05973-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNITFIGSGY VGLVSGIIMG YLGHNVTCLD NDDVKISKLN KKILPIYEAK    50
    LDEYLKHALE SDRLKFTNIY SNEFRNFDAI FITVGTPSKE LGEADLKYVY 100
    DAVDKVSKHI NKDCLIVIKS TVPPGSCNNI IAYLKAKGFS FNVASNPEFL 150
    REGSAVEDFL YPDRIVVGVN NKESEALLRK IYAPLIEQGA KFLVTNLVTS 200
    ELIKYVSNSF LATKIAFINE MADLCEKIGA NIKDLSQGVG LDQRIGRNFL 250
    NAGPGFGGSC FPKDILALNN LVENHKIDCK ILKSVIKSNK LRPSNMVAKI 300
    ATLLDGDLKG RNIAILGLTY KAGTDDVRAS PAIEIITILL NKDVYVKAFD 350
    PIGLENAKKN LEHKNLLYFA SAVEACKSVD IIVIATEWSE FKELNWQEIY 400
    NLVKSPMIID LRNILDNEVM KKIGFRYYAV GSQI 434
    Length:434
    Mass (Da):48,226
    Last modified:July 1, 1997 - v1
    Checksum:i15991BA7112D5036
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11785 Genomic DNA. Translation: CAA72478.1.
    AJ235273 Genomic DNA. Translation: CAA15205.1.
    PIRiE71638.
    RefSeqiNP_221129.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15205; CAA15205; CAA15205.
    GeneIDi883765.
    KEGGirpr:RP779.
    PATRICi17902426. VBIRicPro72556_0815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11785 Genomic DNA. Translation: CAA72478.1 .
    AJ235273 Genomic DNA. Translation: CAA15205.1 .
    PIRi E71638.
    RefSeqi NP_221129.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali O05973.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP779.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15205 ; CAA15205 ; CAA15205 .
    GeneIDi 883765.
    KEGGi rpr:RP779.
    PATRICi 17902426. VBIRicPro72556_0815.

    Phylogenomic databases

    eggNOGi COG1004.
    HOGENOMi HOG000153773.
    KOi K00012.
    OMAi RETNPTA.
    OrthoDBi EOG6ZSP7N.

    Enzyme and pathway databases

    UniPathwayi UPA00038 ; UER00491 .

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028357. UDPglc_DH_bac.
    [Graphical view ]
    PANTHERi PTHR11374. PTHR11374. 1 hit.
    Pfami PF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500134. UDPglc_DH_bac. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence."
      Andersson J.O., Andersson S.G.E.
      Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Madrid E.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiUDG_RICPR
    AccessioniPrimary (citable) accession number: O05973
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3