Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O05970

- ILVE_RICPR

UniProt

O05970 - ILVE_RICPR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable branched-chain-amino-acid aminotransferase

Gene

ilvE

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Acts on leucine, isoleucine and valine.By similarity

Catalytic activityi

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

GO - Molecular functioni

  1. L-isoleucine transaminase activity Source: UniProtKB-EC
  2. L-leucine transaminase activity Source: UniProtKB-EC
  3. L-valine transaminase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. leucine biosynthetic process Source: UniProtKB-UniPathway
  3. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00047; UER00058.
UPA00048; UER00073.
UPA00049; UER00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable branched-chain-amino-acid aminotransferase (EC:2.6.1.42)
Short name:
BCAT
Gene namesi
Name:ilvE
Ordered Locus Names:RP428
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Probable branched-chain-amino-acid aminotransferasePRO_0000103276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei155 – 1551N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi272947.RP428.

Structurei

3D structure databases

ProteinModelPortaliO05970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0115.
HOGENOMiHOG000276706.
KOiK00826.
OMAiKLTEHSE.
OrthoDBiEOG67MF3R.

Family and domain databases

InterProiIPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
[Graphical view]
PANTHERiPTHR11825. PTHR11825. 1 hit.
PfamiPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMiSSF56752. SSF56752. 1 hit.
PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O05970-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMIKLDQIY GYIWINGDLI PYQFARIHVL THSLHYSGSV FEGERAYNGK
60 70 80 90 100
VFKLKEHTER LIQSAESLGL KVPYSVDEII KAHELLIIQN NIKDAYIRPL
110 120 130 140 150
IWCGDESLNI TNPDLSTNFL IASISSMPRS CEQSVHLHVS RWRKAMPNST
160 170 180 190 200
PVQSKSAAQY NMAITSKKEA KALGYDDALL LDYEGFIAEC TTTNIFFVKD
210 220 230 240 250
KTLYTPIADR FLNGITRKTI IEIAKSLCLE VKEERLKLAQ IEHFTGCFVT
260 270 280 290
GTAIEVQNIS SIDLGNKKIL FEDNKIADLL KREYWRIVRG
Length:290
Mass (Da):33,068
Last modified:July 1, 1997 - v1
Checksum:i98374E325350763D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11777 Genomic DNA. Translation: CAA72450.1.
AJ235271 Genomic DNA. Translation: CAA14885.1.
PIRiC71701.
RefSeqiNP_220809.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14885; CAA14885; CAA14885.
GeneIDi883473.
KEGGirpr:RP428.
PATRICi17901637. VBIRicPro72556_0441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11777 Genomic DNA. Translation: CAA72450.1 .
AJ235271 Genomic DNA. Translation: CAA14885.1 .
PIRi C71701.
RefSeqi NP_220809.1. NC_000963.1.

3D structure databases

ProteinModelPortali O05970.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14885 ; CAA14885 ; CAA14885 .
GeneIDi 883473.
KEGGi rpr:RP428.
PATRICi 17901637. VBIRicPro72556_0441.

Phylogenomic databases

eggNOGi COG0115.
HOGENOMi HOG000276706.
KOi K00826.
OMAi KLTEHSE.
OrthoDBi EOG67MF3R.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00058 .
UPA00048 ; UER00073 .
UPA00049 ; UER00062 .

Family and domain databases

InterProi IPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
[Graphical view ]
PANTHERi PTHR11825. PTHR11825. 1 hit.
Pfami PF01063. Aminotran_4. 1 hit.
[Graphical view ]
SUPFAMi SSF56752. SSF56752. 1 hit.
PROSITEi PS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence."
    Andersson J.O., Andersson S.G.E.
    Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Madrid E.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiILVE_RICPR
AccessioniPrimary (citable) accession number: O05970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: October 1, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3