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O05970 (ILVE_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable branched-chain-amino-acid aminotransferase

Short name=BCAT
EC=2.6.1.42
Gene names
Name:ilvE
Ordered Locus Names:RP428
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts on leucine, isoleucine and valine By similarity.

Catalytic activity

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.

L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.

L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.

Sequence similarities

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Probable branched-chain-amino-acid aminotransferase
PRO_0000103276

Amino acid modifications

Modified residue1551N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O05970 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 98374E325350763D

FASTA29033,068
        10         20         30         40         50         60 
MTMIKLDQIY GYIWINGDLI PYQFARIHVL THSLHYSGSV FEGERAYNGK VFKLKEHTER 

        70         80         90        100        110        120 
LIQSAESLGL KVPYSVDEII KAHELLIIQN NIKDAYIRPL IWCGDESLNI TNPDLSTNFL 

       130        140        150        160        170        180 
IASISSMPRS CEQSVHLHVS RWRKAMPNST PVQSKSAAQY NMAITSKKEA KALGYDDALL 

       190        200        210        220        230        240 
LDYEGFIAEC TTTNIFFVKD KTLYTPIADR FLNGITRKTI IEIAKSLCLE VKEERLKLAQ 

       250        260        270        280        290 
IEHFTGCFVT GTAIEVQNIS SIDLGNKKIL FEDNKIADLL KREYWRIVRG 

« Hide

References

« Hide 'large scale' references
[1]"Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence."
Andersson J.O., Andersson S.G.E.
Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Madrid E.
[2]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11777 Genomic DNA. Translation: CAA72450.1.
AJ235271 Genomic DNA. Translation: CAA14885.1.
PIRC71701.
RefSeqNP_220809.1. NC_000963.1.

3D structure databases

ProteinModelPortalO05970.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP428.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14885; CAA14885; CAA14885.
GeneID883473.
KEGGrpr:RP428.
PATRIC17901637. VBIRicPro72556_0441.

Phylogenomic databases

eggNOGCOG0115.
HOGENOMHOG000276706.
KOK00826.
OMAKLTEHSE.
OrthoDBEOG67MF3R.

Enzyme and pathway databases

UniPathwayUPA00047; UER00058.
UPA00048; UER00073.
UPA00049; UER00062.

Family and domain databases

InterProIPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
[Graphical view]
PANTHERPTHR11825. PTHR11825. 1 hit.
PfamPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMSSF56752. SSF56752. 1 hit.
PROSITEPS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVE_RICPR
AccessionPrimary (citable) accession number: O05970
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways