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O05970

- ILVE_RICPR

UniProt

O05970 - ILVE_RICPR

Protein

Probable branched-chain-amino-acid aminotransferase

Gene

ilvE

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Acts on leucine, isoleucine and valine.By similarity

    Catalytic activityi

    L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
    L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.
    L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. L-isoleucine transaminase activity Source: UniProtKB-EC
    2. L-leucine transaminase activity Source: UniProtKB-EC
    3. L-valine transaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
    2. leucine biosynthetic process Source: UniProtKB-UniPathway
    3. valine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00047; UER00058.
    UPA00048; UER00073.
    UPA00049; UER00062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable branched-chain-amino-acid aminotransferase (EC:2.6.1.42)
    Short name:
    BCAT
    Gene namesi
    Name:ilvE
    Ordered Locus Names:RP428
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Probable branched-chain-amino-acid aminotransferasePRO_0000103276Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei155 – 1551N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP428.

    Structurei

    3D structure databases

    ProteinModelPortaliO05970.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0115.
    HOGENOMiHOG000276706.
    KOiK00826.
    OMAiKLTEHSE.
    OrthoDBiEOG67MF3R.

    Family and domain databases

    InterProiIPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    [Graphical view]
    PANTHERiPTHR11825. PTHR11825. 1 hit.
    PfamiPF01063. Aminotran_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF56752. SSF56752. 1 hit.
    PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O05970-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMIKLDQIY GYIWINGDLI PYQFARIHVL THSLHYSGSV FEGERAYNGK    50
    VFKLKEHTER LIQSAESLGL KVPYSVDEII KAHELLIIQN NIKDAYIRPL 100
    IWCGDESLNI TNPDLSTNFL IASISSMPRS CEQSVHLHVS RWRKAMPNST 150
    PVQSKSAAQY NMAITSKKEA KALGYDDALL LDYEGFIAEC TTTNIFFVKD 200
    KTLYTPIADR FLNGITRKTI IEIAKSLCLE VKEERLKLAQ IEHFTGCFVT 250
    GTAIEVQNIS SIDLGNKKIL FEDNKIADLL KREYWRIVRG 290
    Length:290
    Mass (Da):33,068
    Last modified:July 1, 1997 - v1
    Checksum:i98374E325350763D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11777 Genomic DNA. Translation: CAA72450.1.
    AJ235271 Genomic DNA. Translation: CAA14885.1.
    PIRiC71701.
    RefSeqiNP_220809.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14885; CAA14885; CAA14885.
    GeneIDi883473.
    KEGGirpr:RP428.
    PATRICi17901637. VBIRicPro72556_0441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11777 Genomic DNA. Translation: CAA72450.1 .
    AJ235271 Genomic DNA. Translation: CAA14885.1 .
    PIRi C71701.
    RefSeqi NP_220809.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali O05970.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP428.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14885 ; CAA14885 ; CAA14885 .
    GeneIDi 883473.
    KEGGi rpr:RP428.
    PATRICi 17901637. VBIRicPro72556_0441.

    Phylogenomic databases

    eggNOGi COG0115.
    HOGENOMi HOG000276706.
    KOi K00826.
    OMAi KLTEHSE.
    OrthoDBi EOG67MF3R.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00058 .
    UPA00048 ; UER00073 .
    UPA00049 ; UER00062 .

    Family and domain databases

    InterProi IPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    [Graphical view ]
    PANTHERi PTHR11825. PTHR11825. 1 hit.
    Pfami PF01063. Aminotran_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56752. SSF56752. 1 hit.
    PROSITEi PS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence."
      Andersson J.O., Andersson S.G.E.
      Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Madrid E.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiILVE_RICPR
    AccessioniPrimary (citable) accession number: O05970
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3