SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O05966

- SUCC_RICPR

UniProt

O05966 - SUCC_RICPR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Succinyl-CoA ligase [ADP-forming] subunit beta
Gene
sucC, RP433
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi197 – 1971Magnesium or manganese By similarity
Metal bindingi199 – 1991Magnesium or manganese By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 10874ATP By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP
  4. succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER00999.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta (EC:6.2.1.5)
Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name:
SCS-beta
Gene namesi
Name:sucC
Ordered Locus Names:RP433
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Succinyl-CoA ligase [ADP-forming] subunit betaUniRule annotation
PRO_0000102851Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi272947.RP433.

Structurei

3D structure databases

ProteinModelPortaliO05966.
SMRiO05966. Positions 1-385.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 244236ATP-grasp
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG0045.
HOGENOMiHOG000007059.
KOiK01903.
OMAiKVVFMAS.
OrthoDBiEOG644ZT0.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 1 hit.
HAMAPiMF_00558. Succ_CoA_beta.
InterProiIPR011761. ATP-grasp.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PANTHERiPTHR11815. PTHR11815. 1 hit.
PfamiPF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001554. SucCS_beta. 1 hit.
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01016. sucCoAbeta. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O05966-1 [UniParc]FASTAAdd to Basket

« Hide

MNIHEYQAKE ILRKYGVPTS TGLVVTKTEK INETIDKLNT KVYVIKAQIH    50
AGGRGKAGGV KVAKSKEEAK KVAHDMFGIN LVTHQTGPQG QKVNRIYIES 100
GCDILKEYYF SIVFDRSASC ITFIASTEGG VDIEAVAEKM PEKIIKFAVD 150
PATGLQDFHM RGIAYELGFK DNQAKQMKEI VKAVYNAFIE TDATQIEINP 200
LIINSYGNLL ALDAKITFDD NGLFKHPNIT AMRDHDEEDP LETRAANAGL 250
SYVKMDGNIG CMVNGAGLAM ATMDIIKLYG ALPANFLDVG GGADRERVKE 300
ALKIILSDKE VKGILVNIFG GIMRCDIIAE GIIAAAKDIG IKVPLVVRLA 350
GTNVEKGKEI LSNSDLKIIP AHDLADAANK IVEAIR 386
Length:386
Mass (Da):41,978
Last modified:July 1, 1997 - v1
Checksum:i3AF4FD96A5EEEBB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11777 Genomic DNA. Translation: CAA72445.1.
AJ235271 Genomic DNA. Translation: CAA14890.1.
PIRiH71701.
RefSeqiNP_220814.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA14890; CAA14890; CAA14890.
GeneIDi883305.
KEGGirpr:RP433.
PATRICi17901647. VBIRicPro72556_0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11777 Genomic DNA. Translation: CAA72445.1 .
AJ235271 Genomic DNA. Translation: CAA14890.1 .
PIRi H71701.
RefSeqi NP_220814.1. NC_000963.1.

3D structure databases

ProteinModelPortali O05966.
SMRi O05966. Positions 1-385.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272947.RP433.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA14890 ; CAA14890 ; CAA14890 .
GeneIDi 883305.
KEGGi rpr:RP433.
PATRICi 17901647. VBIRicPro72556_0446.

Phylogenomic databases

eggNOGi COG0045.
HOGENOMi HOG000007059.
KOi K01903.
OMAi KVVFMAS.
OrthoDBi EOG644ZT0.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00999 .

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 1 hit.
HAMAPi MF_00558. Succ_CoA_beta.
InterProi IPR011761. ATP-grasp.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view ]
PANTHERi PTHR11815. PTHR11815. 1 hit.
Pfami PF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001554. SucCS_beta. 1 hit.
SUPFAMi SSF52210. SSF52210. 1 hit.
TIGRFAMsi TIGR01016. sucCoAbeta. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence."
    Andersson J.O., Andersson S.G.E.
    Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Madrid E.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.

Entry informationi

Entry nameiSUCC_RICPR
AccessioniPrimary (citable) accession number: O05966
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi