Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O05966

- SUCC_RICPR

UniProt

O05966 - SUCC_RICPR

Protein

Succinyl-CoA ligase [ADP-forming] subunit beta

Gene

sucC

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi197 – 1971Magnesium or manganeseUniRule annotation
    Metal bindingi199 – 1991Magnesium or manganeseUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi35 – 10874ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. manganese ion binding Source: UniProtKB-HAMAP
    4. succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00999.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinyl-CoA ligase [ADP-forming] subunit betaUniRule annotation (EC:6.2.1.5UniRule annotation)
    Alternative name(s):
    Succinyl-CoA synthetase subunit betaUniRule annotation
    Short name:
    SCS-betaUniRule annotation
    Gene namesi
    Name:sucCUniRule annotation
    Ordered Locus Names:RP433
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386Succinyl-CoA ligase [ADP-forming] subunit betaPRO_0000102851Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha and two beta subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi272947.RP433.

    Structurei

    3D structure databases

    ProteinModelPortaliO05966.
    SMRiO05966. Positions 1-385.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 244236ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the succinate/malate CoA ligase beta subunit family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0045.
    HOGENOMiHOG000007059.
    KOiK01903.
    OMAiKVVFMAS.
    OrthoDBiEOG644ZT0.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.261. 1 hit.
    HAMAPiMF_00558. Succ_CoA_beta.
    InterProiIPR011761. ATP-grasp.
    IPR013650. ATP-grasp_succ-CoA_synth-type.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005811. CoA_ligase.
    IPR017866. Succ-CoA_synthase_bsu_CS.
    IPR005809. Succ_CoA_synthase_bsu.
    IPR016102. Succinyl-CoA_synth-like.
    [Graphical view]
    PANTHERiPTHR11815. PTHR11815. 1 hit.
    PfamiPF08442. ATP-grasp_2. 1 hit.
    PF00549. Ligase_CoA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001554. SucCS_beta. 1 hit.
    SUPFAMiSSF52210. SSF52210. 1 hit.
    TIGRFAMsiTIGR01016. sucCoAbeta. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS01217. SUCCINYL_COA_LIG_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O05966-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIHEYQAKE ILRKYGVPTS TGLVVTKTEK INETIDKLNT KVYVIKAQIH    50
    AGGRGKAGGV KVAKSKEEAK KVAHDMFGIN LVTHQTGPQG QKVNRIYIES 100
    GCDILKEYYF SIVFDRSASC ITFIASTEGG VDIEAVAEKM PEKIIKFAVD 150
    PATGLQDFHM RGIAYELGFK DNQAKQMKEI VKAVYNAFIE TDATQIEINP 200
    LIINSYGNLL ALDAKITFDD NGLFKHPNIT AMRDHDEEDP LETRAANAGL 250
    SYVKMDGNIG CMVNGAGLAM ATMDIIKLYG ALPANFLDVG GGADRERVKE 300
    ALKIILSDKE VKGILVNIFG GIMRCDIIAE GIIAAAKDIG IKVPLVVRLA 350
    GTNVEKGKEI LSNSDLKIIP AHDLADAANK IVEAIR 386
    Length:386
    Mass (Da):41,978
    Last modified:July 1, 1997 - v1
    Checksum:i3AF4FD96A5EEEBB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11777 Genomic DNA. Translation: CAA72445.1.
    AJ235271 Genomic DNA. Translation: CAA14890.1.
    PIRiH71701.
    RefSeqiNP_220814.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA14890; CAA14890; CAA14890.
    GeneIDi883305.
    KEGGirpr:RP433.
    PATRICi17901647. VBIRicPro72556_0446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11777 Genomic DNA. Translation: CAA72445.1 .
    AJ235271 Genomic DNA. Translation: CAA14890.1 .
    PIRi H71701.
    RefSeqi NP_220814.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali O05966.
    SMRi O05966. Positions 1-385.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP433.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA14890 ; CAA14890 ; CAA14890 .
    GeneIDi 883305.
    KEGGi rpr:RP433.
    PATRICi 17901647. VBIRicPro72556_0446.

    Phylogenomic databases

    eggNOGi COG0045.
    HOGENOMi HOG000007059.
    KOi K01903.
    OMAi KVVFMAS.
    OrthoDBi EOG644ZT0.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00999 .

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.261. 1 hit.
    HAMAPi MF_00558. Succ_CoA_beta.
    InterProi IPR011761. ATP-grasp.
    IPR013650. ATP-grasp_succ-CoA_synth-type.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005811. CoA_ligase.
    IPR017866. Succ-CoA_synthase_bsu_CS.
    IPR005809. Succ_CoA_synthase_bsu.
    IPR016102. Succinyl-CoA_synth-like.
    [Graphical view ]
    PANTHERi PTHR11815. PTHR11815. 1 hit.
    Pfami PF08442. ATP-grasp_2. 1 hit.
    PF00549. Ligase_CoA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001554. SucCS_beta. 1 hit.
    SUPFAMi SSF52210. SSF52210. 1 hit.
    TIGRFAMsi TIGR01016. sucCoAbeta. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS01217. SUCCINYL_COA_LIG_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence."
      Andersson J.O., Andersson S.G.E.
      Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Madrid E.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiSUCC_RICPR
    AccessioniPrimary (citable) accession number: O05966
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3