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O05966 (SUCC_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta

EC=6.2.1.5
Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta
Gene names
Name:sucC
Ordered Locus Names:RP433
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP-Rule MF_00558

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP-Rule MF_00558

Subunit structure

Heterotetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP-Rule MF_00558
PRO_0000102851

Regions

Domain9 – 244236ATP-grasp
Nucleotide binding35 – 10874ATP By similarity

Sites

Metal binding1971Magnesium or manganese By similarity
Metal binding1991Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
O05966 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 3AF4FD96A5EEEBB8

FASTA38641,978
        10         20         30         40         50         60 
MNIHEYQAKE ILRKYGVPTS TGLVVTKTEK INETIDKLNT KVYVIKAQIH AGGRGKAGGV 

        70         80         90        100        110        120 
KVAKSKEEAK KVAHDMFGIN LVTHQTGPQG QKVNRIYIES GCDILKEYYF SIVFDRSASC 

       130        140        150        160        170        180 
ITFIASTEGG VDIEAVAEKM PEKIIKFAVD PATGLQDFHM RGIAYELGFK DNQAKQMKEI 

       190        200        210        220        230        240 
VKAVYNAFIE TDATQIEINP LIINSYGNLL ALDAKITFDD NGLFKHPNIT AMRDHDEEDP 

       250        260        270        280        290        300 
LETRAANAGL SYVKMDGNIG CMVNGAGLAM ATMDIIKLYG ALPANFLDVG GGADRERVKE 

       310        320        330        340        350        360 
ALKIILSDKE VKGILVNIFG GIMRCDIIAE GIIAAAKDIG IKVPLVVRLA GTNVEKGKEI 

       370        380 
LSNSDLKIIP AHDLADAANK IVEAIR 

« Hide

References

« Hide 'large scale' references
[1]"Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence."
Andersson J.O., Andersson S.G.E.
Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Madrid E.
[2]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11777 Genomic DNA. Translation: CAA72445.1.
AJ235271 Genomic DNA. Translation: CAA14890.1.
PIRH71701.
RefSeqNP_220814.1. NC_000963.1.

3D structure databases

ProteinModelPortalO05966.
SMRO05966. Positions 1-385.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP433.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA14890; CAA14890; CAA14890.
GeneID883305.
KEGGrpr:RP433.
PATRIC17901647. VBIRicPro72556_0446.

Phylogenomic databases

eggNOGCOG0045.
HOGENOMHOG000007059.
KOK01903.
OMAERKFPRR.
OrthoDBEOG644ZT0.
ProtClustDBPRK00696.

Enzyme and pathway databases

UniPathwayUPA00223; UER00999.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 1 hit.
HAMAPMF_00558. Succ_CoA_beta.
InterProIPR011761. ATP-grasp.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PANTHERPTHR11815. PTHR11815. 1 hit.
PfamPF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFPIRSF001554. SucCS_beta. 1 hit.
SUPFAMSSF52210. SSF52210. 1 hit.
TIGRFAMsTIGR01016. sucCoAbeta. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUCC_RICPR
AccessionPrimary (citable) accession number: O05966
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways