O05962 (TLCE_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP,ATP carrier protein 5

Alternative name(s):
ADP/ATP translocase 5

Gene names

Name:	tlcE
Synonyms:	tlc5
Ordered Locus Names:	RP739

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP:ADP antiporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	ADP,ATP carrier protein 5		PRO_0000102584
Regions
	Transmembrane	26 – 46	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	94 – 114	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	184 – 204	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Transmembrane	287 – 307	21	Helical; Potential
	Transmembrane	328 – 348	21	Helical; Potential
	Transmembrane	357 – 377	21	Helical; Potential
	Transmembrane	381 – 401	21	Helical; Potential
	Transmembrane	469 – 489	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O05962 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: FE3DB48D08CF5F72	FASTA	500	57,074
	10 20 30 40 50 60 MLSTSPSRSF KNKFRAAFWP VHNYELGKFI PISALMFCIL FNQNILRILK DSILISEISA 70 80 90 100 110 120 EIAGFAKVYC VTPVAALFVI IYAKMINHLT FEKIFYYLSA FFISCFILFA FVIYPNIHIF 130 140 150 160 170 180 HVHPDTLSDW MNKYPHFKWY ISLVGNWGYI VYYSLAELWP NIFYVLLFWQ FTNELTTTEE 190 200 210 220 230 240 AKRFYTLFSL FGNSSLILVG FLMMNLSSED TIIKKFISIS DSKITLVQVS TTIIAIVAII 250 260 270 280 290 300 CCLLVRFISK YIFTNPLFYH KTKSSRSTAQ RMGLIKSFKY IVKSKYLWLL LICSAAFGFA 310 320 330 340 350 360 INLVEAVWKA KIKELYPTVN TYAEFNSLYI LWTGVAIIVM TIIGNNVMRM HNWFVAAVIS 370 380 390 400 410 420 PVIIMVTGVL FFGLIVFDQQ ILSLFDGAIL MSPLALAVSI GGIQNILAKG TKYSIWDTSR 430 440 450 460 470 480 EMLYIPLDDE LKTKGKAAVD VISAKVGKSS SGLVQSIIFT LVPNATFTSI SPILMVVFTF 490 500 VCFAWIYAVR KIYFEYQKIA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.
[2]	"Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence." Andersson J.O., Andersson S.G.E. Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 325-500. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ235273 Genomic DNA. Translation: CAA15167.1. Y11778 Genomic DNA. Translation: CAA72457.1.
PIR	G71633.
RefSeq	NP_221091.1. NC_000963.1.
3D structure databases
ProteinModelPortal	O05962.
ModBase	Search...
Protein family/group databases
TCDB	2.A.12.1.5. ATP:ADP antiporter (AAA) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15167; CAA15167; CAA15167.
GeneID	883700.
KEGG	rpr:RP739.
PATRIC	17902337. VBIRicPro72556_0772.
Phylogenomic databases
eggNOG	COG3202.
HOGENOM	HOG000238123.
KO	K03301.
OMA	MNLSSED.
ProtClustDB	CLSK870724.
Family and domain databases
InterPro	IPR004667. ADP_ATP_car. [Graphical view]
Pfam	PF03219. TLC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00769. AAA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TLCE_RICPR

Accession

Primary (citable) accession number: O05962

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 30, 2000
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program