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O05962 (TLCE_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP,ATP carrier protein 5
Alternative name(s):
ADP/ATP translocase 5
Gene names
Name:tlcE
Synonyms:tlc5
Ordered Locus Names:RP739
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ADP/ATP translocase tlc family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500ADP,ATP carrier protein 5
PRO_0000102584

Regions

Transmembrane26 – 4621Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane287 – 30721Helical; Potential
Transmembrane328 – 34821Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane381 – 40121Helical; Potential
Transmembrane469 – 48921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O05962 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: FE3DB48D08CF5F72

FASTA50057,074
        10         20         30         40         50         60 
MLSTSPSRSF KNKFRAAFWP VHNYELGKFI PISALMFCIL FNQNILRILK DSILISEISA 

        70         80         90        100        110        120 
EIAGFAKVYC VTPVAALFVI IYAKMINHLT FEKIFYYLSA FFISCFILFA FVIYPNIHIF 

       130        140        150        160        170        180 
HVHPDTLSDW MNKYPHFKWY ISLVGNWGYI VYYSLAELWP NIFYVLLFWQ FTNELTTTEE 

       190        200        210        220        230        240 
AKRFYTLFSL FGNSSLILVG FLMMNLSSED TIIKKFISIS DSKITLVQVS TTIIAIVAII 

       250        260        270        280        290        300 
CCLLVRFISK YIFTNPLFYH KTKSSRSTAQ RMGLIKSFKY IVKSKYLWLL LICSAAFGFA 

       310        320        330        340        350        360 
INLVEAVWKA KIKELYPTVN TYAEFNSLYI LWTGVAIIVM TIIGNNVMRM HNWFVAAVIS 

       370        380        390        400        410        420 
PVIIMVTGVL FFGLIVFDQQ ILSLFDGAIL MSPLALAVSI GGIQNILAKG TKYSIWDTSR 

       430        440        450        460        470        480 
EMLYIPLDDE LKTKGKAAVD VISAKVGKSS SGLVQSIIFT LVPNATFTSI SPILMVVFTF 

       490        500 
VCFAWIYAVR KIYFEYQKIA 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.
[2]"Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence."
Andersson J.O., Andersson S.G.E.
Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 325-500.
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ235273 Genomic DNA. Translation: CAA15167.1.
Y11778 Genomic DNA. Translation: CAA72457.1.
PIRG71633.
RefSeqNP_221091.1. NC_000963.1.

3D structure databases

ProteinModelPortalO05962.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.12.1.5. the atp:adp antiporter (aaa) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15167; CAA15167; CAA15167.
GeneID883700.
KEGGrpr:RP739.
PATRIC17902337. VBIRicPro72556_0772.

Phylogenomic databases

eggNOGCOG3202.
HOGENOMHOG000238123.
KOK03301.
OMAMQHEREA.
OrthoDBEOG6BCSND.
ProtClustDBCLSK870724.

Family and domain databases

InterProIPR004667. ADP_ATP_car.
[Graphical view]
PfamPF03219. TLC. 1 hit.
[Graphical view]
TIGRFAMsTIGR00769. AAA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTLCE_RICPR
AccessionPrimary (citable) accession number: O05962
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names