O05960 (YBEY_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endoribonuclease YbeY
EC=3.1.-.-

Gene names

Name:	ybeY
Ordered Locus Names:	RP741

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA By similarity. HAMAP-Rule MF_00009
Cofactor	Binds 1 zinc ion By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the endoribonuclease YbeY family.
Sequence caution	The sequence CAA15169.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA72455.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC rRNA processing Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	endoribonuclease activity Inferred from electronic annotation. Source: HAMAP metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Endoribonuclease YbeY HAMAP-Rule MF_00009		PRO_0000102519
Sites
	Metal binding	131	1	Zinc; catalytic By similarity
	Metal binding	135	1	Zinc; catalytic By similarity
	Metal binding	141	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	O05960 [UniParc]. Last modified November 28, 2002. Version 2. Checksum: 80454FBAC0BC13E9	FASTA	167	19,969
	10 20 30 40 50 60 MINVEIIRNY NKWREHRKIN KGLIKKITQN VLVRFDNFSK IKQFELSILL TNTAEILTLN 70 80 90 100 110 120 QQFRSIEKAT NVLSFPNNEL NWHNLYSKLE FLYYSDYMHL GDIAFCYEVI YNESCEQQKT 130 140 150 160 FENHFIHMLI HSILHLIGFD HQNDTDANIM ESLEIEILSY FGIPSPY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence." Andersson J.O., Andersson S.G.E. Microbiology 143:2783-2795(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Madrid E.
[2]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11778 Genomic DNA. Translation: CAA72455.1. Different initiation. AJ235273 Genomic DNA. Translation: CAA15169.1. Different initiation.
PIR	A71634.
RefSeq	NP_221093.1. NC_000963.1.
3D structure databases
ProteinModelPortal	O05960.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP741.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15169; CAA15169; CAA15169.
GeneID	883586.
KEGG	rpr:RP741.
PATRIC	17902341. VBIRicPro72556_0774.
Phylogenomic databases
eggNOG	COG0319.
HOGENOM	HOG000132869.
KO	K07042.
ProtClustDB	PRK00016.
Family and domain databases
Gene3D	3.40.390.30. 1 hit.
HAMAP	MF_00009. Endoribonucl_YbeY.
InterPro	IPR023091. MetalPrtase_cat_dom_prd. IPR020549. UPF0054_CS. IPR002036. UPF0054_metalloprotease_prd. [Graphical view]
Pfam	PF02130. UPF0054. 1 hit. [Graphical view]
TIGRFAMs	TIGR00043. TIGR00043. 1 hit.
PROSITE	PS01306. UPF0054. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YBEY_RICPR

Accession

Primary (citable) accession number: O05960

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 28, 2002
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program