Reviewed, UniProtKB/Swiss-Prot O05957 (GLRX2_RICPR)

Names and origin

Protein names

Recommended name:
    Probable monothiol glutaredoxin-2

Gene names

Name:	grxC2
Synonyms:	grlA
Ordered Locus Names:	RP745

Organism

Rickettsia prowazekii [Complete proteome] [HAMAP]

Taxonomic identifier

782 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the glutaredoxin family. Monothiol subfamily. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Redox-active center
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Probable monothiol glutaredoxin-2		PRO_0000102265
Regions
	Domain	7 – 107	101	Glutaredoxin
Sites
	Active site	32	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O05957-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 5B77AA3E394DB4F9	FASTA	107	12,003
	10 20 30 40 50 60 MTKNKNLEFI QNAIKKNKVV LFMKGTKEMP ACGFSGTVVA ILNKLGVEFS DINVLFDTAL 70 80 90 100 REDLKKFSDW PTFPQLYING VLVGGCDIAK ELYQNGELEK MLKDVVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence." Andersson J.O., Andersson S.G.E. Microbiology 143:2783-2795(1997) [PubMed: 9274032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Madrid E.
[2]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y11778 Genomic DNA. Translation: CAA72459.1. Different initiation. AJ235273 Genomic DNA. Translation: CAA15173.1.
PIR	E71634.
RefSeq	NP_221097.1.
3D structure databases
HSSP	HSSP built from PDB template 1JHB based on UniProtKB P35754.
ModBase	Search...
Genome annotation databases
GeneID	883962.
GenomeReviews	Gene locus RP745 in contig AJ235269_GR.
KEGG	rpr:RP745.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O05957.
OMA	O05957. DIVKEMY.
Enzyme and pathway databases
BioCyc	RPRO272947:RP745-MON.
Family and domain databases
InterPro	IPR002109. Glutaredoxin. IPR004480. Glutredox-rel. IPR014434. Monothiol_GRX. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR10293. Glutredox-rel. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PIRSF	PIRSF005894. Monothiol_GRX. 1 hit.
TIGRFAMs	TIGR00365. Glutredox-rel. 1 hit.
PROSITE	PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX2_RICPR

Accession

Primary (citable) accession number: O05957

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 30, 2000
Last modified:	June 16, 2009
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)