O05957 (GLRX2_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable monothiol glutaredoxin-2

Gene names

Name:	grxC2
Synonyms:	grlA
Ordered Locus Names:	RP745

Organism

Rickettsia prowazekii (strain Madrid E)

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities	Belongs to the glutaredoxin family. Monothiol subfamily. Contains 1 glutaredoxin domain.
Sequence caution	The sequence CAA72459.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Redox-active center
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Probable monothiol glutaredoxin-2		PRO_0000102265
Regions
	Domain	7 – 107	101	Glutaredoxin
	Region	86 – 87	2	Glutathione binding By similarity
Sites
	Metal binding	32	1	Iron-sulfur (2Fe-2S); shared with dimeric partner By similarity
	Binding site	24	1	Glutathione By similarity
	Binding site	61	1	Glutathione By similarity
	Binding site	73	1	Glutathione; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	O05957 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 5B77AA3E394DB4F9	FASTA	107	12,003
	10 20 30 40 50 60 MTKNKNLEFI QNAIKKNKVV LFMKGTKEMP ACGFSGTVVA ILNKLGVEFS DINVLFDTAL 70 80 90 100 REDLKKFSDW PTFPQLYING VLVGGCDIAK ELYQNGELEK MLKDVVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic rearrangements during evolution of the obligate intracellular parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp nucleotide sequence." Andersson J.O., Andersson S.G.E. Microbiology 143:2783-2795(1997) [PubMed: 9274032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Madrid E.
[2]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed: 9823893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11778 Genomic DNA. Translation: CAA72459.1. Different initiation. AJ235273 Genomic DNA. Translation: CAA15173.1.
PIR	E71634.
RefSeq	NP_221097.1. NC_000963.1.
3D structure databases
ProteinModelPortal	O05957.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	883962.
GenomeReviews	Gene locus RP745 in contig AJ235269_GR.
KEGG	rpr:RP745.
PATRIC	17902349. VBIRicPro72556_0778.
Phylogenomic databases
HOGENOM	HBG728471.
OMA	NGELEKM.
ProtClustDB	CLSK2484244.
Enzyme and pathway databases
BioCyc	RPRO272947:RP745-MONOMER.
Family and domain databases
InterPro	IPR002109. Glutaredoxin. IPR014434. Monothiol_GRX. IPR004480. Monothiol_GRX-rel. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K07390.
PANTHER	PTHR10293. Glutredox-rel. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PIRSF	PIRSF005894. Monothiol_GRX. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR00365. TIGR00365. 1 hit.
PROSITE	PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX2_RICPR

Accession

Primary (citable) accession number: O05957

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 30, 2000
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program