O05901 (Y909_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Antitoxin Rv0909/MT0933

Gene names

Ordered Locus Names:

Rv0909, MT0933

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	59 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0910/MT0934. Ref.3

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of growth Inferred from mutant phenotype Ref.3. Source: MTBBASE
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 59	59	Antitoxin Rv0909/MT0933		PRO_0000406886

Sequences

	Sequence		Length	Mass (Da)
	O05901 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: E9CCD45DF52044A2	FASTA	59	6,403
	10 20 30 40 50 MGILDKVKNL LSQNADKVET VINKAGEFVD EQTQGNYSDA IHKLHDAASN VVGMSDQQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution." Ramage H.R., Connolly L.E., Cox J.S. PLoS Genet. 5:E1000767-E1000767(2009) [PubMed] [Europe PMC] [Abstract] Cited for: EXPRESSION IN M.SMEGMATIS, FUNCTION AS AN ANTITOXIN. Strain: ATCC 35801 / TMC 107 / Erdman.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000516 Genomic DNA. Translation: AAK45180.1. BX842574 Genomic DNA. Translation: CAB08507.1. AL123456 Genomic DNA. Translation: CCP43657.1.
PIR	E70581.
RefSeq	NP_215424.1. NC_000962.3. NP_335366.1. NC_002755.2. YP_006514263.1. NC_018143.1.
3D structure databases
ProteinModelPortal	O05901.
ModBase	Search...
Protein-protein interaction databases
STRING	83332.Rv0909.
Proteomic databases
PRIDE	O05901.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK45180; AAK45180; MT0933.
GeneID	13318814. 885197. 926248.
KEGG	mtc:MT0933. mtu:Rv0909. mtv:RVBD_0909.
PATRIC	18123798. VBIMycTub22151_1023.
Organism-specific databases
TubercuList	Rv0909.
Phylogenomic databases
eggNOG	NOG327456.
HOGENOM	HOG000041858.
OMA	MIDEKTQ.
ProtClustDB	CLSK790826.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

Y909_MYCTU

Accession

Primary (citable) accession number: O05901
Secondary accession number(s): L0T830, Q7D943

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program