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Protein
Submitted name:

Mannose-6-phosphate isomerase

Gene

manA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971ZincUniRule annotation
Metal bindingi99 – 991ZincUniRule annotation
Metal bindingi134 – 1341ZincUniRule annotation
Metal bindingi264 – 2641ZincUniRule annotation
Active sitei283 – 2831UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • GDP-mannose biosynthetic process Source: InterPro
  • growth Source: MTBBASE
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mannose-6-phosphate isomeraseImported
Submitted name:
Probable mannose-6-phosphate isomerase ManA (Phosphomannose isomerase) (Phosphomannoisomerase) (PMI) (Phosphohexoisomerase) (Phosphohexomutase)Imported
Gene namesi
Name:manAImported
Ordered Locus Names:Rv3255cImported
ORF Names:LH57_17795Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3255c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3255c.

Family & Domainsi

Sequence similaritiesi

Belongs to the mannose-6-phosphate isomerase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EIP. Bacteria.
COG1482. LUCA.
HOGENOMiHOG000241278.
KOiK01809.
OMAiQGEPWDT.
OrthoDBiEOG6130B2.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.

Sequencei

Sequence statusi: Complete.

O05898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLRGALRT YAWGSRTAIA EFTGRPVPAA HPEAELWFGA HPGDPAWLQT
60 70 80 90 100
PHGQTSLLEA LVADPEGQLG SASRARFGDV LPFLVKVLAA DEPLSLQAHP
110 120 130 140 150
SAEQAVEGYL REERMGIPVS SPVRNYRDTS HKPELLVALQ PFEALAGFRE
160 170 180 190 200
AARTTELLRA LAVSDLDPFI DLLSEGSDAD GLRALFTTWI TAPQPDIDVL
210 220 230 240 250
VPAVLDGAIQ YVSSGATEFG AEAKTVLELG ERYPGDAGVL AALLLNRISL
260 270 280 290 300
APGEAIFLPA GNLHAYVRGF GVEVMANSDN VLRGGLTPKH VDVPELLRVL
310 320 330 340 350
DFAPTPKARL RPPIRREGLG LVFETPTDEF AATLLVLDGD HLGHEVDASS
360 370 380 390 400
GHDGPQILLC TEGSATVHGK CGSLTLQRGT AAWVAADDGP IRLTAGQPAK

LFRATVGL
Length:408
Mass (Da):43,371
Last modified:July 1, 1997 - v1
Checksum:i5D55B70C539E1C23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR16048.1.
AL123456 Genomic DNA. Translation: CCP46074.1.
RefSeqiNP_217772.1. NC_000962.3.
WP_003417054.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR16048; AIR16048; LH57_17795.
CCP46074; CCP46074; Rv3255c.
GeneIDi888698.
KEGGimtu:Rv3255c.
mtv:RVBD_3255c.
PATRICi18129126. VBIMycTub22151_3659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR16048.1.
AL123456 Genomic DNA. Translation: CCP46074.1.
RefSeqiNP_217772.1. NC_000962.3.
WP_003417054.1. NZ_KK339370.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3255c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR16048; AIR16048; LH57_17795.
CCP46074; CCP46074; Rv3255c.
GeneIDi888698.
KEGGimtu:Rv3255c.
mtv:RVBD_3255c.
PATRICi18129126. VBIMycTub22151_3659.

Organism-specific databases

TubercuListiRv3255c.

Phylogenomic databases

eggNOGiENOG4105EIP. Bacteria.
COG1482. LUCA.
HOGENOMiHOG000241278.
KOiK01809.
OMAiQGEPWDT.
OrthoDBiEOG6130B2.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiO05898_MYCTU
AccessioniPrimary (citable) accession number: O05898
Secondary accession number(s): F2GKS8, I6YFM0, Q7D5U2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.