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Protein
Submitted name:

Peptide synthetase MbtF (Peptide synthase)

Gene

mbtF

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotation

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6605-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Peptide synthetase MbtF (Peptide synthase)Imported
Gene namesi
Name:mbtFImported
Ordered Locus Names:Rv2379cImported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO05819.
PRIDEiO05819.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv2379c.

Structurei

3D structure databases

ProteinModelPortaliO05819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini966 – 1032Acyl carrierInterPro annotationAdd BLAST67

Phylogenomic databases

eggNOGiCOG1020. LUCA.
HOGENOMiHOG000229991.
KOiK04792.
OMAiHSYLGHA.
PhylomeDBiO05819.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF00668. Condensation. 2 hits.
PF00550. PP-binding. 1 hit.
[Graphical view]
SMARTiSM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O05819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPVAVTRAD ARGAIDDVMA LSPLQQGLFS RATLVAAESG SEAAEADPYV
60 70 80 90 100
IAMAADAAGP LDIALLRDCA AAMLTRHPNL RASFLHGNLS RPVQVIPSSA
110 120 130 140 150
EVLWRHVRAH PSEVGALAAE ERRRRFDVGR GPLIRFLLIE LPDECWHLVI
160 170 180 190 200
VAHHIVIDGW SLPLFVSELL ALYRAGGHVA ALPAAPRPYR DYIGWLAGRD
210 220 230 240 250
QTASRAMWAD HLNGLDGPTL LSPALADTPV QPGIPGRTEV RLDREATAEL
260 270 280 290 300
ADAARTRGVT ISTLVQMAWA TTLSAFTGRG DVTFGVTVSG RPSELSGVET
310 320 330 340 350
MIGLFINTVP LRVRLDARAT VGGQCAVLQR QFAMLRDHSY LGFNEFRAIA
360 370 380 390 400
GIGEMFDTLL VYENFPPGEV VGTAEFVANG VTFRPVALES LSHFPVTVAA
410 420 430 440 450
HRSTGELTLL VEVLDGALGT MAPESLGRRV LAVLQRLVSR WDRPLRDVDI
460 470 480 490 500
LLDGEHDPTA PGLPDVTTSA PAVHTRFAEI AAAQPDSVAV SWADGQLTYR
510 520 530 540 550
ELDALADRLA TGLRRADVSR ETPVAVALSR GPRYVAAMLA VLKAGGMIVP
560 570 580 590 600
LDPAMPGERV AEILRQTSAP VVIDEGVFAA SVGADILEED RAITVPVDQA
610 620 630 640 650
AYVIFTSGTT GTPKGVIGTH RALSAYADDH IERVLRPAAQ RLGRPLRIAH
660 670 680 690 700
AWSFTFDAAW QPLVALLDGH AVHIVDDHRQ RDAGALVEAI DRFGLDMIDT
710 720 730 740 750
TPSMFAQLHN AGLLDRAPLA VLALGGEALG AATWRMIQQN CARTAMTAFN
760 770 780 790 800
CYGPTETTVE AVVAAVAEHA RPVIGRPTCT TRAYVMDSWL RPVPDGVAGE
810 820 830 840 850
LYLAGAQLTR GYLGRPAETA ARFVAEPNGR GSRMYRTGDV VRRLPDGGLE
860 870 880 890 900
FLGRSDDQVK IRGFRVEPGE IAAVLNGHHA VHGCHVTARG HASGPRLTAY
910 920 930 940 950
VAGGPQPPPV AELRAMLLER LPRYLVPHHI VVLDELPLTP HGKIDENALA
960 970 980 990 1000
AINVTEGPAT PPQTPTELVL AEAFADVMET SNVDVTAGFL QMGLDSIVAL
1010 1020 1030 1040 1050
SVVQAARRRG IALRARLMVE CDTIRELAAA IDSDAAWQAP ANDAGEPIPV
1060 1070 1080 1090 1100
LPNTHWLYEY GDPRRLAQTE VIRLPDRITR ERLDAVLAAV VDGHEVLRCR
1110 1120 1130 1140 1150
FDRDAMALVA QPKTDILSEV WVSGELVTAV AEQTLGALAS LDPQAGRLLS
1160 1170 1180 1190 1200
AVWLREPDGP GVLVLTAHVL AMDPASWRIV LGELDAGLHA LAAGRAPSPA
1210 1220 1230 1240 1250
RENTSYRQWS RLLAQRAKAL DSVDFWVAEL EGADPPLGAR RVAPQTDRVG
1260 1270 1280 1290 1300
ELAITMSISD ADLTARLLST GRSMTDLLAT AAARMVTAWR RQRGQQTPAP
1310 1320 1330 1340 1350
LLALETHGRA DVHVDKTADT SDTVGLLSAI YPLRIHCDGA TDFARIPGSG
1360 1370 1380 1390 1400
IDYGLLRYLR ADTAERLRAH REPQLLLNYL GSLHVGVGDL AVDRALLADV
1410 1420 1430 1440 1450
GQLPEPEQPV RHELTVLAAL LGPADAPVLA TRWRTLPDIL SADDVATLQS
1460
LWQGALAEIT A
Length:1,461
Mass (Da):156,748
Last modified:July 1, 1997 - v1
Checksum:iDF0E91018B19C9BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45167.1.
RefSeqiNP_216895.1. NC_000962.3.
WP_003916032.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP45167; CCP45167; Rv2379c.
GeneIDi885874.
KEGGimtu:Rv2379c.
mtv:RVBD_2379c.
PATRICi18153873. VBIMycTub87468_2660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45167.1.
RefSeqiNP_216895.1. NC_000962.3.
WP_003916032.1. NZ_KK339370.1.

3D structure databases

ProteinModelPortaliO05819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2379c.

Proteomic databases

PaxDbiO05819.
PRIDEiO05819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP45167; CCP45167; Rv2379c.
GeneIDi885874.
KEGGimtu:Rv2379c.
mtv:RVBD_2379c.
PATRICi18153873. VBIMycTub87468_2660.

Phylogenomic databases

eggNOGiCOG1020. LUCA.
HOGENOMiHOG000229991.
KOiK04792.
OMAiHSYLGHA.
PhylomeDBiO05819.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6605-MONOMER.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF00668. Condensation. 2 hits.
PF00550. PP-binding. 1 hit.
[Graphical view]
SMARTiSM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO05819_MYCTU
AccessioniPrimary (citable) accession number: O05819
Secondary accession number(s): I6Y952, L0TC57
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.